RESUMO
C/EBPß, a member of the bHLH gene family of DNA-binding transcription factors, has been indicated as a central signal in physiologic hypertrophy. However, the role of C/EBPß in pathological cardiac hypertrophy remains to be elucidated. In this study, we revealed that C/EBPß is involved in cardiac hypertrophy, the expression of C/EBPß were significantly increased in response to hypertrophic stimulation in vitro and in vivo. C/EBPß knockdown inhibited PE-induced cardiac hypertrophy, and diminished the nuclear translocation and DNA binding activity of p65-NFκB. These results suggested that C/EBPß knockdown protected cardiomyocytes from hypertrophy, which may be attributed to inhibition of NFκB-dependent transcriptional activity. These findings shed new light on the understanding of C/EBPß-related cardiomyopathy, and suggest the potential application of C/EBPß inhibitors in cardiac hypertrophy.
