1.
ACS Omega
; 7(28): 24824-24837, 2022 Jul 19.
Artigo
em Inglês
| MEDLINE
| ID: mdl-35874238
RESUMO
A late-stage functionalization (LSF) of the natural product andrographolide for the efficient assembly of a range of structurally interesting and diverse tricyclic-aza derivatives was developed. The key to the diversification is a photo-catalyzed intramolecular hydroamination reaction, and acridinium derivatives were demonstrated to be the optimal catalysts. Additionally, the synthesized tricyclic aza-andrographolide derivatives were found to inhibit human coronavirus with high potency.