Targeting Protein Aggregates with Natural Products: An Optional Strategy for Neurodegenerative Diseases.

Protein aggregation is one of the hallmarks of aging and aging-related diseases, especially for the neurodegenerative diseases (NDs) such as Alzheimer's disease (AD), Parkinson's disease (PD), Huntington's disease (HD), Amyotrophic lateral sclerosis (ALS), and others. In these diseases, many pathogenic proteins, such as amyloid-ß, tau, α-Syn, Htt, and FUS, form aggregates that disrupt the normal physiological function of cells and lead to associated neuronal lesions. Protein aggregates in NDs are widely recognized as one of the important targets for the treatment of these diseases. Natural products, with their diverse biological activities and rich medical history, represent a great treasure trove for the development of therapeutic strategies to combat disease. A number of in vitro and in vivo studies have shown that natural products, by virtue of their complex molecular scaffolds that specifically bind to pathogenic proteins and their aggregates, can inhibit the formation of aggregates, disrupt the structure of aggregates and destabilize them, thereby alleviating conditions associated with NDs. Here, we systematically reviewed studies using natural products to improve disease-related symptoms by reducing or inhibiting the formation of five pathogenic protein aggregates associated with NDs. This information should provide valuable insights into new directions and ideas for the treatment of neurodegenerative diseases.

Social-contextual influences on public participation in incentive programs of household waste separation.

Despite the widespread use of financial incentives to encourage public participation in household waste separation, recent studies have revealed the mixed success of this strategy. The present study seeks to advance our understanding of the social-contextual conditions in which financial incentives are more or less effective. Based on theories of social influence, it has investigated how program advocates, neighbor networks, and community norms affect public participation in incentivized waste-separation programs. Generalized linear mixed model analyses of more than 150,000 daily participation records for residents in 347 housing estates in Hangzhou, China have been conducted to examine the theoretical propositions. The results show that substituting ingroup members (block leaders) for outgroup agents (company staff) as program advocates increased the total number of participants. However, block leaders contributed little or even negatively to mobilizing people who had never participated previously. Levels of participation were higher among residents with stronger social networks, but lower in communities with more salient volunteerism norms. These findings illuminate the substantial interaction between financial incentives and social influences, suggesting ways to use social forces to improve incentive programs of household waste separation.