RESUMO
OBJECTIVE@#To investigate the relationship between the expression of cyclooxygenase-2 (COX-2) and the carcinogenesis and invasive behavior of nasal and paranasal sinus carcinoma (NPSC).@*METHOD@#The expression of COX-2 were detected in 69 case NPSC tissues, paracancerous atypical hyperplasia tissue and normal tissue by using immunohistochemical techniques of SP method.@*RESULT@#The positive rate of COX-2 in NPSC tissues and atypical hyperplasia tissue and normal tissue was 65.22% and 42.31% and 3.33%, respectively. The positive rate of COX-2 in NPSC tissues was significantly higher than that in normal tissue (P < 0.01), and increased apparently with the lesion progressing from normal to atypical hyperplasia tissue to NPSC tissues, and also correlated with the increasing of tumor (P < 0.05).@*CONCLUSION@#COX-2 may play an important role in the carcinogenesis and invasion of NPSC.
Assuntos
Idoso , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Ciclo-Oxigenase 2 , Metabolismo , Cavidade Nasal , Patologia , Estadiamento de Neoplasias , Neoplasias Nasais , Metabolismo , Patologia , Neoplasias dos Seios Paranasais , Metabolismo , PatologiaRESUMO
OBJECTIVE@#To study the expression of cyclooxygenase-2 (COX-2) and matrix metalloproteinase-2 (MMP-2) in nasopharyngeal carcinoma (NPC) and their relationship with lymph node metastasis.@*METHOD@#The expression of COX-2 and MMP-2 in 86 NPC tissues and 30 normal nasopharyngeal tissues were evaluated by immunohistochemical analysis.@*RESULT@#The positive rate of COX-2 and MMP-2 in NPC tissue was 75.58% and 66.28% respectively, which was significantly higher than that in normal nasopharyngeal (P < 0.01). The expression of both COX-2 and MMP-2 were positively correlated with lymph node metastasis (P < 0.01). There was a positive correlation between the expression of COX-2 and MMP-2 (P < 0.01).@*CONCLUSION@#COX-2 and MMP-2 expression are increased in NPC, and they may cooperate in the course of lymph metastasis of NPC.
