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Curr Biol ; 34(7): 1453-1468.e6, 2024 04 08.
Artigo em Inglês | MEDLINE | ID: mdl-38484733

RESUMO

Itch encompasses both sensory and emotional dimensions, with the two dimensions reciprocally exacerbating each other. However, whether a shared neural circuit mechanism governs both dimensions remains elusive. Here, we report that the anterior insular cortex (AIC) is activated by both histamine-dependent and -independent itch stimuli. The activation of AIC elicits aversive emotion and exacerbates pruritogen-induced itch sensation and aversion. Mechanistically, AIC excitatory neurons project to the GABAergic neurons in the dorsal bed nucleus of the stria terminalis (dBNST). Manipulating the activity of the AIC → dBNST pathway affects both itch sensation and itch-induced aversion. Our study discovers the shared neural circuit (AIC â†’ dBNST pathway) underlying the itch sensation and aversion, highlights the critical role of the AIC as a central hub for the itch processing, and provides a framework to understand the neural mechanisms underlying the sensation and emotion interaction.


Assuntos
Córtex Insular , Sensação , Humanos , Sensação/fisiologia , Neurônios GABAérgicos/metabolismo , Histamina/efeitos adversos , Histamina/metabolismo , Prurido/induzido quimicamente
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