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1.
Molecules ; 29(7)2024 Mar 28.
Artigo em Inglês | MEDLINE | ID: mdl-38611797

RESUMO

Vernonia patula Merr. (VP) is a traditional medicine used by the Zhuang and Yao people, known for its therapeutic properties in treating anemopyretic cold and other diseases. Distinguishing VP from similar varieties such as Praxelis clematidea (PC), Ageratum conyzoides L. (AC) and Ageratum houstonianum Mill (AH) was challenging due to their similar traits and plant morphology. The HPLC fingerprints of 40 batches of VP and three similar varieties were established. SPSS 20.0 and SIMCA-P 13.0 were used to statistically analyze the chromatographic peak areas of 37 components. The results showed that the similarity of the HPLC fingerprints for each of the four varieties was >0.9, while the similarity between the control chromatogram of VP and its similar varieties was <0.678. Cluster analysis and partial least squares discriminant analysis provided consistent results, indicating that all four varieties could be individually clustered together. Through further analysis, we found isochlorogenic acid A and isochlorogenic acid C were present only in the original VP, while preconene II was present in the three similar varieties of VP. These three components are expected to be identification points for accurately distinguishing VP from PC, AC and AH.


Assuntos
Ageratum , Vernonia , Humanos , Cromatografia Líquida de Alta Pressão , Análise por Conglomerados , Análise Discriminante
2.
Nat Prod Res ; 37(8): 1271-1276, 2023 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-34758689

RESUMO

A new anthraquinone, asperquinone A (1), and four known anthraquinone derivatives 2-5 were isolated from the mangrove endophytic fungus Aspergillus sp. 16-5C. These structures were elucidated by spectroscopic analysis and the absolute configuration of 1 was unambiguously determined by ECD calculation. Compounds 1-5 showed no significant inhibitory effect against Mycobacterium tuberculosis protein tyrosine phosphatase B (MptpB).


Assuntos
Aspergillus , Mycobacterium tuberculosis , Aspergillus/química , Fungos , Análise Espectral , Antraquinonas/farmacologia , Estrutura Molecular
4.
Org Lett ; 21(23): 9633-9636, 2019 12 06.
Artigo em Inglês | MEDLINE | ID: mdl-31762277

RESUMO

A pair of enantiomeric indole diketopiperazine alkaloid dimers [(-)- and (+)-asperginulin A (1a and 1b)] with an unprecedented 6/5/4/5/6 pentacyclic skeleton were isolated from the mangrove endophytic fungus Aspergillus sp. SK-28. The enantiomeric dimers were separated by chiral-phase HPLC. Their structures including absolute configurations were elucidated by spectroscopic analysis, X-ray diffraction, and quantum chemical calculation. (+)-Asperginulin A (1b) exhibited antifouling activity against the barnacle Balanus reticulatus.


Assuntos
Alcaloides , Aspergillus/química , Dicetopiperazinas , Endófitos/química , Indóis , Rhizophoraceae/microbiologia , Alcaloides/química , Alcaloides/isolamento & purificação , Alcaloides/farmacologia , Animais , Incrustação Biológica , Dicetopiperazinas/química , Dicetopiperazinas/isolamento & purificação , Dicetopiperazinas/farmacologia , Dimerização , Indóis/química , Indóis/isolamento & purificação , Indóis/farmacologia , Estrutura Molecular , Estereoisomerismo , Thoracica/efeitos dos fármacos
5.
Nanoscale ; 11(34): 15881-15891, 2019 Aug 29.
Artigo em Inglês | MEDLINE | ID: mdl-31464330

RESUMO

A porous composite electrode composed of diatomite-mixed 1,4,5,8-naphthalenetetracarboxylic dianhydride (NTCDA) is prepared by electrostatic spinning technology. Compared with traditional coated electrodes without diatomite mixing, the obtained composite electrode materials have higher porosity, larger specific surface area and faster lithium ion transport channels, which makes them exhibit better electrochemical performance, such as smaller impedance, higher capacity, and better cycling stability and rate performance. The electrospun diatomite-mixed 1,4,5,8-NTCDA composite (ED-1,4,5,8-NTCDA) electrode shows an initial coulombic efficiency of 77.2%, which is much higher than that of the electrospun 1,4,5,8-NTCA (E-1,4,5,8-NTCDA) electrode without diatomite mixing (63.8%) and the coated 1,4,5,8-NTCA (C-1,4,5,8-NTCDA) electrode (48.3%). Moreover, the ED-1,4,5,8-NTCDA electrode displays an initial discharge capacity of 1106.5 mA h g-1, which is much higher than that of the E-1,4,5,8-NTCDA electrode (546.0 mA h g-1) and the C-1,4,5,8-NTCDA electrode (185.4 mA h g-1). After 200 cycles, the capacity of the ED-1,4,5,8-NTCDA electrode remains at 1008.5 mA h g-1 with a retention ratio of 91.2%, which is also much higher than that of 753.2 mA h g-1 for the E-1,4,5,8-NTCDA electrode and 288.1 mA h g-1 for the C-1,4,5,8-NTCDA electrode. Even at a higher current density of 1500 mA g-1, its capacity remains above 508.9 mA h g-1. The ED-1,4,5,8-NTCDA electrode presents superior performance, which opens up a promising new approach for further utilization of organic materials as electrode materials in rechargeable lithium-ion batteries.

6.
Anal Sci ; 33(6): 715-717, 2017.
Artigo em Inglês | MEDLINE | ID: mdl-28603191

RESUMO

Rhodamine B was forbidden in food by law because of its carcinogenic properties to humans. However, due to its low cost, it was often used to dope chili oil by some counterfeiters to improve its natural color. However, it was difficult to quantify rhodamine B in chili oil due to its complex substrates and high viscosity. In this study, deep eutectic solvents, comprised of choline chloride and ethylene glycol, were first used as an extraction medium to separate rhodamine B from chili oil.


Assuntos
Formiatos/química , Óleos de Plantas/química , Rodaminas/análise , Água/química , Cromatografia Líquida de Alta Pressão , Estrutura Molecular , Solventes/química , Espectrometria de Fluorescência
7.
Molecules ; 22(5)2017 May 03.
Artigo em Inglês | MEDLINE | ID: mdl-28467349

RESUMO

One new meroterpenoid, named 2-hydroacetoxydehydroaustin (1), together with nine known meroterpenoids, 11-acetoxyisoaustinone (2), isoaustinol (3), austin (4), austinol (5), acetoxydehydroaustin (6), dehydroaustin (7), dehydroaustinol (8), preaustinoid A2 (9), and 1,2-dihydro-acetoxydehydroaustin B (10), were isolated from the mangrove endophytic fungus, Aspergillus sp. 16-5c. These structures were characterized by spectroscopic analysis, further the absolute configurations of stereogenic carbons for Compounds 1, 3, 4, 6, 7, 8, 9, and 10 were determined by single crystal X-ray diffraction analysis using Cu Kα radiation. Moreover, the absolute configurations of stereogenic carbons for Known Compounds 3, 7, 8, and 9 are identified here for the first time. Compounds 3, 7, and 8 showed acetylcholinesterase (AchE) inhibitory activity with IC50 values of 2.50, 0.40, and 3.00 µM, respectively.


Assuntos
Aspergillus/química , Inibidores da Colinesterase/química , Endófitos/química , Lythraceae/microbiologia , Terpenos/química , Acetilcolinesterase/química , Linhagem Celular Tumoral , Inibidores da Colinesterase/isolamento & purificação , Inibidores da Colinesterase/farmacologia , Cristalografia por Raios X , Humanos , Estrutura Molecular , Terpenos/isolamento & purificação , Terpenos/farmacologia
8.
Beilstein J Org Chem ; 12: 2077-2085, 2016.
Artigo em Inglês | MEDLINE | ID: mdl-27829913

RESUMO

The chemical investigation of the mangrove endophytic fungus Aspergillus sp. 085242 afforded eight isocoumarin derivatives 1-8 and one isoquinoline 9. Asperisocoumarins A and B (1 and 2) were new furoisocoumarins, and asperisocoumarins E and F (5 and 6) were new isocoumarins. Their structures were established by analysis of their spectroscopic data and the absolute configuration of compound 2 was unambiguously determined by X-ray structure analysis and ECD calculation. Moreover, the absolute configurations of compounds 3-5 were assigned by comparison of their ECD spectra with isocoumarins described in the literature. Asperisocoumarins C and D (3 and 4) were fully characterized spectroscopically and isolated from a natural source for the first time. Asperisocoumarins A-D (1-4) related to the class of furo[3,2-h]isocoumarins are rarely occurring in natural sources. Compounds 2, 5, and 6 showed moderate α-glucosidase inhibitory activity with IC50 of 87.8, 52.3, and 95.6 µM, respectively. In addition, compounds 1 and 3 exhibited weak radical scavenging activity with EC50 values of 125 and 138 µM, respectively.

9.
Mar Drugs ; 13(1): 366-78, 2015 Jan 13.
Artigo em Inglês | MEDLINE | ID: mdl-25591039

RESUMO

Racemic dinaphthalenone derivatives, (±)-asperlone A (1) and (±)-asperlone B (2), and two new azaphilones, 6'-hydroxy-(R)-mitorubrinic acid (3) and purpurquinone D (4), along with four known compounds, (-)-mitorubrinic acid (5), (-)-mitorubrin (6), purpurquinone A (7) and orsellinic acid (8), were isolated from the cultures of Aspergillus sp. 16-5C. The structures were elucidated using comprehensive spectroscopic methods, including 1D and 2D NMR spectra and the structures of 1 further confirmed by single-crystal X-ray diffraction analysis, while the absolute configuration of 3 and 4 were determined by comparing their optical rotation and CD with those of the literature, respectively. Compounds 1, 2 and 6 exhibited potent inhibitory effects against Mycobacterium tuberculosis protein tyrosine phosphatase B (MptpB) with IC50 values of 4.24 ± 0.41, 4.32 ± 0.60 and 3.99 ± 0.34 µM, respectively.


Assuntos
Aspergillus/química , Compostos Heterocíclicos de 4 ou mais Anéis/isolamento & purificação , Naftóis/isolamento & purificação , Proteínas de Bactérias/antagonistas & inibidores , Compostos Heterocíclicos de 4 ou mais Anéis/química , Espectroscopia de Ressonância Magnética , Estrutura Molecular , Naftóis/química , Proteínas Tirosina Fosfatases/antagonistas & inibidores , Difração de Raios X
10.
Nat Prod Res ; 28(2): 111-4, 2014.
Artigo em Inglês | MEDLINE | ID: mdl-24205843

RESUMO

Xylanthraquinone (1), a new anthraquinone, along with three known compounds, altersolanol A (2), deoxybostrycin (3) and bostrycin (4) was isolated from the fungus Xylaria sp. 2508 from the South China Sea. The structures of these compounds were identified by NMR experiments, and the absolute configuration of compound 1 was further confirmed by single-crystal X-ray diffraction with Cu Kα radiation. Compounds 1-4 did not show inhibitory activities against Mycobacterium tuberculosis protein tyrosine phosphatase B (IC50 values more than 100 µM).


Assuntos
Antraquinonas/isolamento & purificação , Xylariales/química , Antraquinonas/química , Antraquinonas/farmacologia , China , Cristalografia por Raios X , Concentração Inibidora 50 , Estrutura Molecular , Mycobacterium tuberculosis/efeitos dos fármacos , Oceanos e Mares , Proteína Tirosina Fosfatase não Receptora Tipo 1/efeitos dos fármacos
11.
Org Lett ; 15(10): 2522-5, 2013 May 17.
Artigo em Inglês | MEDLINE | ID: mdl-23642191

RESUMO

Asperterpenol A (1) and asperterpenol B (2), two novel sesterterpenoids with an unusual 5/8/6/6 tetracyclic ring skeleton, were isolated from a mangrove endophytic fungus Aspergillus sp. 085242. The structures were elucidated on the basis of spectroscopic methods and the absolute configurations determined by single-crystal X-ray diffraction analysis. Compounds 1 and 2 inhibit acetylcholinesterase with IC50 values of 2.3 and 3.0 µM, respectively.


Assuntos
Aspergillus/química , Fungos/química , Sesterterpenos/química , Sesterterpenos/isolamento & purificação , Cristalografia por Raios X , Estrutura Molecular , Análise Espectral
12.
J Nat Prod ; 74(5): 997-1002, 2011 May 27.
Artigo em Inglês | MEDLINE | ID: mdl-21510637

RESUMO

Eight secondary metabolites, including three new azaphilones (chermesinones A-C, 1-3), three new p-terphenyls (6'-O-desmethylterphenyllin, 4; 3-hydroxy-6'-O-desmethylterphenyllin, 5; 3''-deoxy-6'-O-desmethylcandidusin B, 7), and two known p-terphenyls (6, 8), were isolated from the culture of the mangrove endophytic fungus Penicillium chermesinum (ZH4-E2). Their structures were established by spectroscopic analysis. The absolute configuration of 1 was determined by X-ray crystallography. Terphenyls 4, 5, and 6 exhibited strong inhibitory effects against α-glucosidase with IC50 values of 0.9, 4.9, and 2.5 µM, respectively. Terphenyls 7 and 8 showed inhibitory activity toward acetylcholinesterase with IC50 values of 7.8 and 5.2 µM.


Assuntos
Benzopiranos/isolamento & purificação , Inibidores da Colinesterase/isolamento & purificação , Inibidores da Colinesterase/farmacologia , Inibidores de Glicosídeo Hidrolases , Penicillium chrysogenum/química , Pigmentos Biológicos/isolamento & purificação , Compostos de Terfenil/isolamento & purificação , Benzopiranos/química , Benzopiranos/farmacologia , Inibidores da Colinesterase/química , Cristalografia por Raios X , Concentração Inibidora 50 , Estrutura Molecular , Oceanos e Mares , Pigmentos Biológicos/química , Pigmentos Biológicos/farmacologia , Rhizophoraceae/microbiologia , Compostos de Terfenil/química , Compostos de Terfenil/farmacologia
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