[Current situation and consideration of medical instrument clinical trial in China].

OBJECTIVE: To improve the quality of medical instrument clinical trial in China. METHODS: A systematic analysis on current situation of medical instrument clinical trial in China is conducted to find a way out of problems. RESULTS & CONCLUSIONS: There is a low level of medical instrument clinical trial now in China. There are still many shortcomings in law and regulations of medical instrument clinical trial. The sponsors and s do not know medical instrument clinical trial well, the measures of quality related to medical instrument clinical trial must be improved.

[The inhibition of compound lightyellow sophora root collutory on oral bacteria].

PURPOSE: To study the inhibition of compound lightyellow sophora root collutory on oral bacteria. METHODS: The standard strains of common oral bacteria were cultured and proliferated by corresponding media in vitro. The minimum inhibitory concentration (MIC), MIC(50), MIC(90) of compound lightyellow sophora root collutory were determined. The bacteriostatic effects were determined by the plating method. RESULTS: The MIC of compound lightyellow sophora root collutory were lower than the stock solution concentration. It was showed that compound lightyellow sophora root collutory had the same effect as tea polyphenol on oral bacteria. To Actinomyces naeslundii, compound lightyellow sophora root collutory inhibited the bacteria growth more obviously than tea polyphenol. The result showed that there was no remarkable difference between the compound lightyellow sophora root collutory and tea polyphenol by the plating method. CONCLUSION: Compound lightyellow sophora root collutory can inhibit the oral bacteria growth obviously.

[A clinical study of doxycycline slow-release gel on periodontitis chemotherapy].

OBJECTIVE: To observe the effect of Doxycycline slow-release on periodontitis therapy. METHODS: 30 patients with chronic periodontitis were chosen and divided into 2 groups randomly,these cases were given Doxycycline slow-release and Zinciodati Comp solution. PLI,GI,SBI,PD,AL,MD and clinical symptoms were observed before and after taking drug. RESULTS: The indose of PLI,GI,SBI,PD,AL,MD were decreased significantly after the use of Doxycycline slow-release gel (P<0.05),the effects of the Doxycycline was better than Zinciodati Comp solution (P<0.01), no adverse drug side effects were found during trial. CONCLUSION: The use of Doxycycline slow-release gel is one of the safe and effective chemotherapy on periodontitis.