RESUMO
PURPOSE: To investigate the effect of simvastatin on the function of MG63 cell line. METHODS: The function of proliferation, osteoprotegerin (OPG) and osteocalcin (OC) gene expression, and migration of MG63 cells were detected with MTT, fluorescent real-time PCR and micro chemotaxis, respectively. The data was analyzed using ANOVA followed by Tukey test with SPSS14.0 software package. RESULTS: 10-9mol/L and 10-8mol/L concentrations of simvastatin slightly promoted MG63 cell proliferation; 10-7mol/L and 10-6mol/L concentrations of simvastatin greatly enhanced the OPG and OC mRNA expression; All concentrations of simvastatin had an inhibitory effect on MG63 cell migration. CONCLUSION: Simvastatin could promote bone defect regeneration by enhancing the bone-related genes expression.
