Progress in study on etiology of ovarian epithelial cancer / 中国癌症杂志

Epithelial ovarian cancer, which is one of the most lethal gynecological tumors, is also the biggest dififculty in the diagnosis and treatment of obstetrics and gynecology. In addition to the lack of early clinical symptoms and effective diagnostic methods, the reason includes the lack of accurate and comprehensive understanding of the development of epithelial ovarian cancer. Thus a lot of research aimed at better grasp of its pathogenesis, which is expected in the future progress of its diagnosis and treatment. Currently, three pathogenesis of epithelial ovarian cancer widely accepted are high gonadotropin theory, “dualism” hypothesis and stem cell hypothesis. This study discussed the theory above.

Effects of Saponin Extracted from Zea Mays L (ZMLS) on Pathogenic Diabetic Mouse Model Caused by Administration of Alloxan and Glucose / 中华中医药杂志

Objective: To observe the effects of Saponin Extracted from Zea Mays L(ZMLS) on reducing blood sugar in pathogenic diabetic mouse models.Methods: The pathogenic diabetic mouse models were established successfully by intravenous injection of small dose of alloxan and intragastric administration of glucose.Modeling state of pathogenic diabetic mice and the effects of Saponin Extracted from Zea Mays L(ZMLS) on pathogenic diabetic mouse models were observed through the levels of blood sugar and serum of insulin and the pathology changes of islet cells.Results: It was successful to establish pathogenic diabetic mouse models by intravenous injection of small dose of alloxan and intragastric administration of glucose.ZMLS had good action of lowering the level of blood glucose on this model and had good action of preventing the pancreatic island ?-cell from the injury induced by drugs.Conclusion: ZMLS has good therapy effects on pathogenic diabetic mouse models induced by intravenous injection of small dose of alloxan and intragastric administration of glucose.

Effect of total saponin of stibmata maydis on carbohydrate tolerance reducing mice model induced by Dexamethasone and ?-glucosidase activity in vitro / 中华中医药杂志

Objective:To explore the mechanism and characteristics of total saponin of stibmata maydis in decreasing blood glucose by study the effect total saponin of stibmata maydis on carbohydrate tolerance reducing mice model and ?-glucosidase activity in vitro.Methods:The model was established by intramuscular injecting Dexamethasone.Fasting blood sugar and serum blood sugar level were measured to observe the effect of total saponin of stibmata maydis.An enzyme-inhibitor model was established to study the effect of total saponin of stibmata maydis on ?-glucosidase activity.Results:Compared with model group,total saponin of stibmata maydis of middle dosage can remarkably reduce blood sugar level after irrigating the glucose for 30min,60min and 20min;high and low dose of total saponin of stibmata maydis and the group of Diamicron can obviously reduce the blood glucose level at every time period;total saponin of stibmata maydis can inhibit the activity of ?-glucosidase in vitro and have obvious dose-effect relationship.Fifty percent of ?-glucosidase activity is inhibited at 45.07?l(20mg/ml).Conclusion:Total saponin of stibmata maydis had the remarkable function of improving carbohydrate tolerance on reducing mice model induced by Dexamethasone and inhibits ?-glucosidase activity.