RESUMO
This paper reports a new technique to repair defects of the lip. It has been done in nine patients (2 upper lips and 7 lower lips), and the resultant oral configuration and function are satisfactory. The design and procedure are described in detail. The advantage of the method, the point for attention in performing the operation, and some problems in the repair of vermilion are discussed.
Assuntos
Carcinoma de Células Escamosas/cirurgia , Neoplasias Labiais/cirurgia , Retalhos Cirúrgicos , Adolescente , Adulto , Idoso , Carcinoma Basocelular/cirurgia , Criança , Pré-Escolar , Feminino , Humanos , Lábio/cirurgia , Masculino , Pessoa de Meia-IdadeRESUMO
Of the 166 patients receiving autogenous mandibular bone grafts during 1972-1987, 55 were used for repair of mandibular bone defect, 67 for correction of maxillofacial malformation and 44 for reconstruction of temporo-mandibular joint. Follow-up showed that 155 patients had satisfactory results after operation.
Assuntos
Transplante Ósseo , Mandíbula/cirurgia , Disostose Mandibulofacial/cirurgia , Articulação Temporomandibular/cirurgia , Adolescente , Adulto , Idoso , Criança , Ossos Faciais/anormalidades , Feminino , Humanos , Masculino , Maxila/anormalidades , Pessoa de Meia-Idade , Transtornos da Articulação Temporomandibular/cirurgiaRESUMO
Mitochondrially bound rat brain hexokinase was labeled with the photoactivatable reagent, 3-(trifluoromethyl)-3-(m-[125I]iodophenyl)diazirine. This highly hydrophobic reagent is strongly partitioned into the hydrophobic environment of the membrane core, and thus selectively labels segments of a protein that penetrate this region of the membrane. Labeling of hexokinase was shown to be restricted to the N-terminal region of the molecule. Approximately 80% of the radiolabel was removed by treatment of the enzyme with chymotrypsin, which preferentially cleaves a hydrophobic 9-residue sequence at the extreme N-terminus of the enzyme, and it is considered likely that the remaining 20% was associated with two additional hydrophobic residues, immediately adjacent to this segment but not susceptible to cleavage by chymotrypsin. Labeling of the enzyme was shown to be dependent on maintenance of the association with the membrane. These results are consistent with a model in which binding of hexokinase involves insertion of an 11-residue hydrophobic N-terminal "tail," possibly existing in alpha-helical secondary structure, into the hydrophobic core of the membrane.