RESUMO
AIM: To explore the clinical value of serum soluble intercellular adhesion molecule-1 (sICAM-1) in patients with primary hepatocellular carcinoma (PHC) and its relationship with liver fibrosis. METHODS: The serun sICAM-1, PC III, IV-C, LN and HA level of 45 cases of patients with PHC, 30 cases of benign tumor and 35 cases of healthy people were determined by ELISA, the relationship between sICAM-1 and liver fibrosis was analyzed. RESULTS: The serum sICAM-1, PC III, IV-C, LN and HA levels of the PHC group were significantly higher than that of the benign tumor group and normal control group, compared the difference was significant (P<0.05); The serum markers was no significant difference between the benign tumor group and normal control group (P>0.05); The serum sICAM-1 was positively correlated with the PC III, IV-C, LN and HA (γ= 0.683, 0.575, 0.573 and 0.539, P<0.05). CONCLUSION: Detection of serum sICAM-1 has important clinical significance for assessing the PHC patient's condition, early diagnosing and treating liver cancer.
Assuntos
Carcinoma Hepatocelular/sangue , Carcinoma Hepatocelular/patologia , Molécula 1 de Adesão Intercelular/sangue , Cirrose Hepática/sangue , Cirrose Hepática/patologia , Neoplasias Hepáticas/sangue , Neoplasias Hepáticas/patologia , Adulto , Idoso , Colágeno Tipo III/sangue , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , PrognósticoAssuntos
Desastres , Incidentes com Feridos em Massa , Medicina Naval , Adolescente , Adulto , Idoso , Criança , Pré-Escolar , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Adulto JovemRESUMO
OBJECTIVE: To establish a canine model of penetrating craniocerebral gunshot wound. METHOD: Gunshot wound was induced in 54 cross-bred dogs using 7.62-mm pistol bullets fired using a pistol from a distance of 30 cm in coronal direction with a tilt of 10 degrees toward the orbit, causing penetrating craniocerebral injury 1 cm posterior and 1.5 cm superior to the lateral canthus. The breathing and pathological changes in the brain tissue were observed after the injury. RESULTS: Autonomous breathing was recovered in 9 out of 21 dogs with respiratory arrest after the injury, and the total survival rate was 77.8% in the 54 dogs after the injury. Intracranial hematoma, intracranial pneumatosis, contusion and laceration of brain, and cranial bone fragments were found by cranial CT, with the entrance and exit of the bullet seen on the right and left frontal bone respectively. Pathological examination showed contusion and laceration of the brain tissues. CONCLUSION: The model of craniocerebral perforating wound has been successfully established in dogs.
