RESUMO
Objective: To sort out the knowledge structure and summarize the current development in the fields related, by summarizing the research on commonly used acupoints by moxibustion for the treatment of lumbar disc herniation, LDH.Methods: Citespace software was used to create the atlas of acupoints commonly used by moxibustion for the treatment of lumbar disc herniation and the atlas was analyzed. The data obtained was used to data back to the literature and summarize its development of the field. Results: In the field of moxibustion treatment of lumbar disc herniation, traditional acupoints, have been studied mostly. With the deepening of the research, some new ideas and methods have been gradually formed, such as heat sensitive points and heat sensitive moxibustion. Conclusion: The research on moxibustion treating LDH common acupoints scattered. It is hoped that the cooperation between scholars and research groups in this field will be made, laying a solid foundation for the future research.
RESUMO
Osteoarthritis (OA) is a common long-term complication of developmental dysplasia of the hip (DDH) that is associated with a higher incidence of OA. In addition, the age of onset of OA in DDH patients is significantly younger than in the general population. In order to investigate the early degeneration in DDH cartilage, we used a rat DDH model that was established by the straight-leg swaddling position. The hips were isolated from the DDH model rats and an untreated control group at postnatal weeks 2, 4, 6, and 8. Histology and proteoglycan levels were observed in articular cartilage using Safranin O staining. Biomarkers of cartilage degeneration, including type X collagen and matrix metalloproteinase (MMP)-13, were assessed using immunohistochemistry and quantitative real-time polymerase chain reaction. In addition, expressions of ADAMTS-4 and ADAMTS-5 were studied using quantitative real-time polymerase chain reaction at different ages. DDH rats showed decreased proteoglycans and derangement of chondrocytes when compared with the control group. Collagen X and MMP-13 expressions were higher in the superficial zone of DDH rats than in that of controls (p < 0.05), and the increase was age-dependent. mRNA expression of Collagen X and MMP-13 showed similar results (p < 0.05). A significant increase in mRNA expression of ADAMTS-5 was found in the DDH model cartilage at 8 weeks (p < 0.05). However, no change was observed in ADAMTS-4 expression. This study shows that degenerative cartilage changes occur at an early stage in the rat DDH model and become aggravated with age.
