RESUMO
BACKGROUND: Most case reports on laryngeal granuloma formation have described patients after tracheotomy and single-lumen endotracheal intubation. Few studies have investigated vocal cord granuloma formation after double-lumen endotracheal (DLT) intubation. CASE SUMMARY: We report granulation tissue formation on the bilateral vocal cords after DLT intubation in a 45-year-old, 153-cm-tall female patient. Previous imaging reports showed no formation of vocal cord granuloma before DLT intubation. Therefore, we inferred that DLT intubation may have been the main reason for the postoperative granulation tissue formation on her bilateral vocal cords, based on the patient's history of DLT intubation, persistent hoarseness after thoracic surgery, and fibrolaryngoscopic and pathological reports during 12 mo follow-up. CONCLUSION: Thirty-two Fr DLT tubes should be utilized for thoracic surgery on female patients who are shorter than 153 cm in height.
RESUMO
Investigation of the ethanol extract of the whole plant of Ainsliaea yunnanensis led to the isolation of four new dimeric sesquiterpene lactones, ainsliadimer F-I (1-4), together with seven known dimeric sesquiterpene lactones (5-11) and ten sesquiterpenes (12-21). Their structures were elucidated by spectroscopic methods. The relative stereochemistry of ainsliadimer F was further confirmed by single crystal X-ray diffraction analysis. Compounds 1-21 were tested for the inhibition of nuclear factor kappa B (NF-κB) in the 293-NF-κB-luciferase reporter cell line induced by lipopolysaccharide (LPS), and Compounds 5, 18, 20 and 21 were further tested for the production of TNF-α, IL-1ß, IL-6 and IL-10 in RAW 264.7 macrophages induced by LPS. Compounds 5, 18, 20 and 21 exhibited significant activity in anti-inflammatory activity assays.
