Design of personal health information acquisition terminal system / 医疗卫生装备

Objective To acquire the physiological parameters such as pulse,blood oxygen saturation and ECG to realize personal health information monitoring and tailored medical service.Methods A personal health information acquisition terminal was developed,which was composed of an information acquisition module,personal computer and system software.The information acquisition module was developed with USB interface and unified circuit mode.Health information was transmitted to the personal computer at real time with USB interface,and then stored by system software and uploaded to the database.Results The terminal gained advantages in design,convenience and practicability,which realized realtime acquisition,data storage,remote auxiliary diagnosis,printing and etc of personal health information,so that personal information realtime monitoring was implemented.Concluslon The terminal can be used for health information recording,storage,acquisition and analysis,and extends medical service of hospital.

Research and development of portable hypertension therapeutic apparatus based on biofeedback mechanism / 生物医学工程学杂志

Non-drug treatment of hypertension has become a research hotspot, which might overcome the heavy economic burden and side effects of drug treatment for the patients. Because of the good treatment effect and convenient operation, a new treatment based on slow breathing training is increasingly becoming a kind of physical therapy for hypertension. This paper explains the principle of hypertension treatment based on slow breathing training method, and introduces the overall structure of the portable blood pressure controlling instrument, including breathing detection circuit, the core control module, audio module, memory module and man-machine interaction module. We give a brief introduction to the instrument and the software in this paper. The prototype testing results showed that the treatment had a significant effect on controlling the blood pressure.

A novel remote controlled capsule for site-specific drug delivery in human GI tract.

Remote controlled capsule (RCC) has been extensively used in the field of site-specific drug delivery. It is a potent tool to study the regional drug absorption of the gastrointestinal (GI) tract that provides pharmaceutical scientists with significant pharmacokinetics data for oral drug formulation development. In present investigations, a patented novel RCC has been devised based on micro-electronic mechanical system (MEMS) technology. Micro-thrusters were for the first time exploited as drug release actuators of RCCs. As the micro-thruster is ignited by a radio frequency (RF) signal, the thrust force generated by the propellants pushes the piston forward and leads to a rapid and complete expulsion of therapeutic agents from the capsule. The micro-thruster merely consumes 120 mW for ignition and the duration time of drug release is decreased to less than 1 s. The feasibility of the novel RCC was evaluated through animal experiments in beagles using aminophylline as the model drug. The novel RCC developed is a promising alternative for site-specific drug delivery in human GI tract.

Methods applied to muscle fatigue assessment using surface myoelectric signals / 生物医学工程学杂志

Surface myoelectric signal analysis has proved effective for assessing the electrical manifestations of localized muscle fatigue. In the past, the analysis of muscle fatigue was restricted to isometric, constant force contractions due to the limitation of signal processing technique. The development and recent availability of spectral estimation techniques specifically designed for nonstationary signal analysis have made it possible to extend the employment of muscle fatigue assessment to dynamic contractions, thus opening new application fields such as ergonomics rehabilitation and sports medicine. This paper reviews the current study achievements of using surface myoelectric signals in muscle fatigue assessment, particularly in that during dynamic contractions. The conclusions provide theoretical bases for encouraging further studies on the mechanisms of muscle fatigue.

A Novel Remote Controlled Capsule for Human Drug Absorption studies.

Remote Controlled Capsule (RCC) is a new method to realize non-invasive drug delivery to the selected sites of human gastro-intestinal (GI) tract. With RCC, Human Drug Absorption (HDA) studies are taken easily to obtain data on the intestinal absorption of a drug in humans. In this paper, a new RCC system has been designed based on MEMS technology to provide for the delivery of a wide range of different drug formulations, for example, solution, powder and granulate, into any region of the gut. A magnetic Marker Monitoring (MMM) system was developed to monitor the location of the capsule inside the gut. A novel method to indicating the drug release, called as Indicating System based on Abrupt Movement of Marker (ISAMM), was proposed in this study. High reliability of the RCC system has been proved by animal experiments.