Experiments study on mechanical behavior of porcine lumbar intervertebral disc after nucleotomy under compression / 生物医学工程学杂志

In order to study the mechanical behavior of degeneration and nucleotomy of lumbar intervertebral disc, compression experiments with porcine lumbar intervertebral discs were carried out. The lumbar intervertebral discs with trypsin-treated and nucleus nucleotomy served as the experimental group and the normal discs as the control group. Considering the effects of load magnitude and loading rate, the relationship between stress and strain, instantaneous elastic modulus and creep property of intervertebral disc were obtained. The creep constitutive model was established. The results show that the strain and creep strain of the experimental group increase significantly with the increase of compression load and loading rate, whereas the instantaneous elastic modulus decreases obviously, compared with the control group. It indicates that the effect of load magnitude and loading rate on load-bearing capacity of intervertebral disc after nucleotomy is larger obviously than that of normal disc. The creep behavior of the experimental group can be still predicted by the Kelvin three-parameter solid model. The results will provide theoretical foundation for clinical treatment and postoperative rehabilitation of intervertebral disc disease.

Clinical therapeutic effect of Tangbining granule in the treatment of dia-betic peripheral neuropathy and on oxidative stress / 中国现代医生

Objective To observe the clinical curative effect of Tangbining granule in the treatment of diabetic periph-eral neuropathy syndrome of Yang deficiency and blood stasis type and the effect on oxidative stress. Methods selec-tion of diabetic peripheral neuropathy in patients with syndrome of Yang deficiency and blood stasis type, on the basis of the control group adds the clothing Tangbining granule, with symptom scores as the criterion of curative effect ob-servation of sugar,Tangbining granule in the treatment of diabetic peripheral neuropathy (DPN)effectiveness,safety,and observed before and after treatment with indicators of oxidative stress in the body superoxide dismutase enzyme(SOD)and malondialdehyde(MDA)changes. Results The total efficiency of the control group 70.37%,the total effec-tive rate of treatment group was 92.59%,there was significant difference between two groups (P<0.05); the SOD and MDA changes of the control group had no significant difference before and after the treatment, the SOD and MDA changes of the treatment group before and after treatment were statistically differences,and there was significant differ-ence in the change of MDA and SOD after treatment between two groups. There was no adverse reaction in two groups. Conclusion Tangbining granule in the treatment of diabetic peripheralneuropathy with Yang deficiency and blood stasis syndrome has exact curative effect,at the same time can improve oxidative stress in the body,without adverse reaction.

Huangqi-Guizhi-Wuwudecoction for diabetic peripheral neuropathy / 国际中医中药杂志

ObjectiveTo evaluate the therapeutic effect ofHuangqi-Guizhi-Wuwu decoction in patients with diabetic peripheral neuropathy (DPN).MethodsA total of 78 patients with DNP were included and divided into a control group and a treatment group, with 39 in each group. The patients in the control group were administrated with appropriate exercise, control diet, hypoglycemics, mecobalamin and vitamin B1, those in the treatment group were receivedHuangqi-Guizhi-Wuwu decoction on the basis of the control group. The patients in both groups were treated for 8 weeks. The serum activities of superoxide dismutase (SOD), glutathione peroxidase (GPx) and catalase were determined by enzymatic-colorimetric method, and the serum malondialdehyde level was measured using colorimetric method. Sensory nerve conduction velocity (SCV) and motor nerve conduction velocity (MCV) were measured using an Electromyograph and Evoked Potential Equipment.ResultsAfter treatment, MCV (43.12 ± 4.1 m/svs. 40.27 ± 2.8 m/s;t=3.585,P<0.05)、SCV (41.51 ± 3.4 m/svs. 39.63 ± 3.5 m/s;t=2.406,P<0.05) in the treatment group were significantly increased than those in the control group. The serum activities of SOD (51.1 ± 6.6 U/mlvs. 47.6 ± 3.9 U/ml;t=2.851,P<0.01),GSH-Px (241.7 ± 36.1 U/mlvs. 213.9 ± 31.7 U/ml;t=3.614,P<0.01) in the treatment group were significantly increased than those in the control group. The total efficiency in the treatment group was significantly higher than that in the control group (87.2%vs. 69.2%;χ2=4.333,P=0.033).ConclusionsHuangqi-Guizhi-Wuwu decoction combined with conventional therapy could improve antioxidant capacity and control DPN progress in patients with DPN.