Effect of prophylactic use of hydrolyzed protein formula on gastrointestinal diseases and physical growth in preterm infants: a Meta analysis / 中国当代儿科杂志

OBJECTIVES@#To systematically evaluate the effect of prophylactic use of hydrolyzed protein formula on gastrointestinal diseases and physical development in preterm infants.@*METHODS@#A computerized search was performed in the databases including China National Knowledge Infrastructure, Wanfang Data, Weipu, PubMed, Embase, and the Cochrane Library to identify randomized controlled trials of the effect of prophylactic use of hydrolyzed protein formula on gastrointestinal diseases and physical growth in preterm infants. RevMan 5.3 software was used to perform a Meta analysis for the included studies.@*RESULTS@#A total of 7 randomized controlled studies were included. The results of Meta analysis showed that compared with the whole protein formula, the prophylactic use of hydrolyzed protein formula could reduce the risk of neonatal necrotizing enterocolitis (RR=0.40, P=0.04) and feeding intolerance (RR=0.40, P=0.005), and had no significant effect on the growth of weight, length and head circumference (P>0.05).@*CONCLUSIONS@#Compared with the whole protein formula, the prophylactic use of hydrolyzed protein formula in preterm infants may reduce the occurrence of necrotizing enterocolitis and feeding intolerance, and can meet the nutrient requirement of physical development. However, the evidence is limited, and the results of this study cannot support the routine prophylactic use of hydrolyzed protein formula in preterm infants.

Efficacy and safety of fluconazole in prophylaxis of invasive fungal infections in very low birth weight infants: a Meta analysis / 中国当代儿科杂志

OBJECTIVE@#To assess the efficacy and safety of fluconazole in the prophylaxis of invasive fungal infection in very low birth weight (VLBW) infants.@*METHODS@#Databases including PubMed, Embase, the Cochrane Library, Wanfang Data, Weipu, and CNKI were searched for randomized controlled trials (RCTs) of prophylactic fluconazole in VLBW infants. Review Manager 5.3 software was used to perform a Meta analysis of the included studies.@*RESULTS@#A total of 12 RCTs were included, involving 1 679 VLBW infants. The Meta analysis showed that prophylactic fluconazole significantly reduced the incidence of invasive fungal infection (RR=0.44, 95%CI: 0.27-0.71, P0.05). No significant differences were found in the incidence of fluconazole resistance and complications between the fluconazole and control groups (P>0.05).@*CONCLUSIONS@#Prophylactic fluconazole can effectively and safely prevent invasive fungal infection in VLBW infants, even at a small dose.

[Degradation and kinetics of pyrene and benzo [a] pyrene by three bacteria in contaminated soil].

Degradation kinetics of pyrene and benzo [a] pyrene (BaP) in soil by three individual strains of bacteria were examined using the Michaelis-Menton and Monod dynamic models. There were significant differences occurred in the degradation rates of pyrene and BaP by the three individual strains. When the initial concentrations of pyrene or BaP was 50 mg/kg in soil, the degradation rates of pyrene by Bacillus sp. SB02, Zoogloea sp.SB09, and Flavobacterium sp.SB10 in 42 days were 42.69%, 32.88% and 25.07% respectively for pyrene. Similarly, degradation rates of BaP by Bacillus sp. SB02, Zoogloea sp. SB09, and Flavobacterium sp. SB10 in 42 days were 33.04%, 25.39% and 22.02% respectively for BaP. In addition, there also were significant differences occurred in the degradation rates per day of pyrene and BaP by the three individual strains. The most rapid degradation of pyrene and BaP by Bacillus sp. SB02 occurred in one week, and 20.88% of pyrene and 12.6% of BaP were degraded. However, Zoogloea sp. SB09 had a slower degradation, while Flavobacterium sp. SB10 had the slowest degradation.

Microbial changes in rhizospheric soils contaminated with petroleum hydrocarbons after bioremediation.

Effects of bioremediation on microbial communities in soils contaminated with petroleum hydrocarbons are a scientific problem to be solved. Changes in dominate microbial species and the total amount of microorganisms including bacteria and fungi in rhizospheric soils after bioremediation were thus evaluated using field bioremediation experiments. The results showed that there were changed dominant microorganisms including 11 bacterial strains which are mostly Gram positive bacteria and 6 fungal species which were identified. The total amount of microorganisms including bacteria and fungi increased after bioremediation of microbial agents combined with planting maize. On the contrary, fungi in rhizospheric soils were inhibited by adding microbial agents combined with planting soybean.