A Zero-Voltage-Writing Artificial Nervous System Based on Biosensor Integrated on Ferroelectric Tunnel Junction.

The artificial nervous system proves the great potential for the emulation of complex neural signal transduction. However, a more bionic system design for bio-signal transduction still lags behind that of physical signals, and relies on additional external sources. Here, this work presents a zero-voltage-writing artificial nervous system (ZANS) that integrates a bio-source-sensing device (BSSD) for ion-based sensing and power generation with a hafnium-zirconium oxide-ferroelectric tunnel junction (HZO-FTJ) for the continuously adjustable resistance state. The BSSD can use ion bio-source as both perception and energy source, and then output voltage signals varied with the change of ion concentrations to the HZO-FTJ, which completes the zero-voltage-writing neuromorphic bio-signal modulation. In view of in/ex vivo biocompatibility, this work shows the precise muscle control of a rabbit leg by integrating the ZANS with a flexible nerve stimulation electrode. The independence on external source enhances the application potential of ZANS in robotics and prosthetics.

A laser-engraved wearable gait recognition sensor system for exoskeleton robots.

As a reinforcement technology that improves load-bearing ability and prevents injuries, assisted exoskeleton robots have extensive applications in freight transport and health care. The perception of gait information by such robots is vital for their control. This information is the basis for motion planning in assistive and collaborative functions. Here, a wearable gait recognition sensor system for exoskeleton robots is presented. Pressure sensor arrays based on laser-induced graphene are developed with flexibility and reliability. Multiple sensor units are integrated into an insole to detect real-time pressure at key plantar positions. In addition, the circuit hardware and the algorithm are designed to reinforce the sensor system with the capability of gait recognition. The experimental results show that the accuracy of gait recognition by the proposed system is 99.85%, and the effectiveness of the system is further verified through testing on an exoskeleton robot.

Reversible Thermoelectric Regulation of Electromagnetic and Chemical Enhancement for Rapid SERS Detection.

Actively controlling surface-enhanced Raman scattering (SERS) performance plays a vital role in highly sensitive detection or in situ monitoring. Nevertheless, it is still challenging to achieve further modulation of electromagnetic enhancement and chemical enhancement simultaneously in SERS detection. In this study, a silver nanocavity structure with graphene as a spacer layer is coupled with thermoelectric semiconductor P-type gallium nitride (GaN) to form an electric-field-induced SERS (E-SERS) for dual enhancement. After applying the electric field, the intensity of SERS signals is further enhanced by over 10 times. The thermoelectric field enables fast and reproducible doping of graphene, thereby modulating its Fermi level over a wide range. The thermoelectric field also regulates the position of the plasmon resonance peak of the silver nanocavity structure, rendering synchronous dual electromagnetic and chemical regulation. Additionally, the method enables the trace detection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). A detailed theoretical analysis is performed based on the experimental results and finite-element calculations, paving the way for the fabrication of high-efficient E-SERS substrates.

Reprogrammable, intelligent soft origami LEGO coupling actuation, computation, and sensing.

Tightly integrating actuation, computation, and sensing in soft materials allows soft robots to respond autonomously to their environments. However, fusing these capabilities within a single soft module in an efficient, programmable, and compatible way is still a significant challenge. Here, we introduce a strategy for integrating actuation, computation, and sensing capabilities in soft origami. Unified and plug-and-play soft origami modules can be reconfigured into diverse morphologies with specific functions or reprogrammed into a variety of soft logic circuits, similar to LEGO bricks. We built an untethered autonomous soft turtle that is able to sense stimuli, store data, process information, and perform swimming movements. The function multiplexing and signal compatibility of the origami minimize the number of soft devices, thereby reducing the complexity and redundancy of soft robots. Moreover, this origami also exhibits strong damage resistance and high durability. We envision that this work will offer an effective way to readily create on-demand soft robots that can operate in unknown environments.

Laser Direct Writing of Flexible Thermal Flow Sensors.

Thin film-based thermal flow sensors afford applications in healthcare and industries owing to their merits in preserving initial flow distributions. However, traditional thermal flow sensors are primarily applied to track flow intensities based on hot-wire or hot-film sensing mechanisms due to their relatively facile device configurations and fabrication strategies. Herein, a calorimetric thermal flow sensor is proposed based on laser direct writing to form laser-induced graphene as heaters and temperature sensors, resulting in monitoring both flow intensities and orientations. Via homogeneously surrounding spiral heaters with multiple temperature sensors, the device exhibits high sensitivity (∼162 K·s/m) at small flows with an extended flow detection range (∼25 m/s). Integrating the device with a data-acquisition board and a dual-mode graphical user interface enables wirelessly and dynamically monitoring respiration and the motion of robotic arms. This versatile flow sensor with facile manufacturing affords potentials in health inspection, remote monitoring, and studying hydrodynamics.

Machine Learning-Enabled Tactile Sensor Design for Dynamic Touch Decoding.

Skin-like flexible sensors play vital roles in healthcare and human-machine interactions. However, general goals focus on pursuing intrinsic static and dynamic performance of skin-like sensors themselves accompanied with diverse trial-and-error attempts. Such a forward strategy almost isolates the design of sensors from resulting applications. Here, a machine learning (ML)-guided design of flexible tactile sensor system is reported, enabling a high classification accuracy (≈99.58%) of tactile perception in six dynamic touch modalities. Different from the intuition-driven sensor design, such ML-guided performance optimization is realized by introducing a support vector machine-based ML algorithm along with specific statistical criteria for fabrication parameters selection to excavate features deeply concealed in raw sensing data. This inverse design merges the statistical learning criteria into the design phase of sensing hardware, bridging the gap between the device structures and algorithms. Using the optimized tactile sensor, the high-quality recognizable signals in handwriting applications are obtained. Besides, with the additional data processing, a robot hand assembled with the sensor is able to complete real-time touch-decoding of an 11-digit braille phone number with high accuracy.

Screen printing and laser-induced flexible sensors for the simultaneous sensitive detection of uric acid, tyrosine, and ascorbic acid in sweat.

A wearable sweat sensor, which could continuously monitor biomolecules related to the human physiological state, is emerging as a promising piece of health surveillance equipment. However, current sensors cannot simultaneously achieve a detection performance that equates to that of traditional sensors and satisfactory mechanical strength. Herein, a wearable sweat sensor with excellent detection performance and mechanical stability is designed and fabricated. Based on the integration of laser-induced graphene electrodes and a screen printing technique, this wearable sweat sensor could realize both the separate and simultaneous detection of uric acid (UA), tyrosine (Tyr), and ascorbic acid (AA) with high sensitivity. Good UA sensing performance in artificial sweat could be maintained even after 20 000 bends. In addition, the sensor can operate well in the wearing state or in a complex bovine whole blood sample. For the detection of human sweat, the changes in UA concentration after a purine-rich meal are continuously monitored and the results are in accordance with the corresponding serum UA detection results tested with a commercial serum UA meter. These results suggest its application potential in health monitoring for both gout patients and healthy humans.

Extremely Sensitive SERS Sensors Based on a Femtosecond Laser-Fabricated Superhydrophobic/-philic Microporous Platform.

The detection of molecules from highly diluted solutions with a limited amount is vital for precancer diagnosis, food safety, and forensic analysis. The sensitivity and convenience of detection techniques are the primary concerns. In this study, a hybrid superhydrophobic/-philic (SH/SHL) microporous platform is designed and fabricated by a femtosecond laser to improve surface-enhanced Raman scattering (SERS) performances. Relying on the micropores fabricated at the center of SHL patterns, sediments distributed at the central regions are avoided, leading to the further enrichment of the target molecules. The engineered micropores with high identification further improve the speed of Raman tests, and the fabricated SERS substrate shows an advantage in outdoor handheld detection and automated inspection applications. The optimized SERS sensor is sufficient for attomolar-level detection (10-17 M) of rhodamine 6G using analyte volumes of just 5 µL, corresponding to an enhancement factor of 5.19 × 1013. Meanwhile, a relative standard deviation of 7.48% at 10-10 M shows the excellent uniformity of this proposed SERS platform. This work further pushes forward the practical applications of SERS technology in ultratrace molecular detections.

Multifunctional Flexible Humidity Sensor Systems Towards Noncontact Wearable Electronics.

In the past decade, the global industry and research attentions on intelligent skin-like electronics have boosted their applications in diverse fields including human healthcare, Internet of Things, human-machine interfaces, artificial intelligence and soft robotics. Among them, flexible humidity sensors play a vital role in noncontact measurements relying on the unique property of rapid response to humidity change. This work presents an overview of recent advances in flexible humidity sensors using various active functional materials for contactless monitoring. Four categories of humidity sensors are highlighted based on resistive, capacitive, impedance-type and voltage-type working mechanisms. Furthermore, typical strategies including chemical doping, structural design and Joule heating are introduced to enhance the performance of humidity sensors. Drawing on the noncontact perception capability, human/plant healthcare management, human-machine interactions as well as integrated humidity sensor-based feedback systems are presented. The burgeoning innovations in this research field will benefit human society, especially during the COVID-19 epidemic, where cross-infection should be averted and contactless sensation is highly desired.

Femtosecond laser patterned superhydrophobic/hydrophobic SERS sensors for rapid positioning ultratrace detection.

Ultratrace molecular detections are vital for precancer diagnosis, forensic analysis, and food safety. Superhydrophobic (SH) surface-enhanced Raman scattering (SERS) sensors are regarded as an ideal approach to improve detection performance by concentrating analyte molecules within a small volume. However, due to the low adhesion of SH surfaces, the analyte droplet is prone to rolling, making it hard to deposit molecules on a predetermined position. Furthermore, the sediment with a very small area on the SH-SERS surface is difficult to be captured even with a Raman microscope. In this study, femtosecond laser fabricated hybrid SH/hydrophobic (SH/HB) surfaces are successfully applied to realize a rapid and highly sensitive SERS detection. By modulating dual surface structures and wetting behaviors, the analyte molecules can be enriched at the edge of HB pattern. This improves the convenience and speed of Raman test. On a hybrid SH/HB SERS substrate with a circular HB pattern at 300-µm-diameter, a femtomolar level (10-14 M) of rhodamine 6G can be detected by using analyte volumes of just 5 µL. The SERS enhancement factor can reach 5.7×108 and a good uniformity with a relative standard deviation of 6.98% is achieved. Our results indicate that the laser fabrication of hybrid SERS sensor offers an efficient and cost-effective approach for ultratrace molecular detection.

Wireless and Flexible Skin Moisture and Temperature Sensor Sheets toward the Study of Thermoregulator Center.

A disorder in the thermoregulator center in a human body leads to some potential diseases such as fever and hyperthyroidism. To predict these diseases early, monitoring the health condition of the human body due to the influence of thermoregulation disorders is important. Although extensive works are performed on sweat-rate detection by constructing microfluidic channels, skin-moisture evaporation before sweating remains unknown. This work proposes a wireless and flexible sensor sheet to investigate the thermoregulatory responses of different people under cold stimulation and exercise by measuring the temperature and moisture variations on the finger skin. An integrated flexible sensor system consists of a ZnIn2 S4 nanosheet-based humidity sensor and carbon nanotube/SnO2 temperature sensor. The results exhibit distinct thermoregulation abilities of five volunteers. Interestingly, the sudden increase in finger moisture that results from the excitation by the sympathetic nerve is observed during the cold-stimulus test. Although further studies are required to predict the potential diseases resulted from thermoregulation disorders in human body, this study provides a possibility of continuous and real-time monitoring of thermoregulatory activities via skin moisture and temperature detection using a flexible sensor sheet.

A Wearable Body Condition Sensor System with Wireless Feedback Alarm Functions.

Emerging feedback systems based on tracking body conditions can save human lives. In particular, vulnerable populations such as disabled people, elderly, and infants often require special care. For example, the high global mortality of infants primarily owing to sudden infant death syndrome while sleeping makes request for extraordinary attentions in neonatal intensive care units or daily lives. Here, a versatile laser-induced graphene (LIG)-based integrated flexible sensor system, which can wirelessly monitor the sleeping postures, respiration rate, and diaper moisture with feedback alarm notifications, is reported. A tilt sensor based on confining a liquid metal droplet inside a cavity can track at least 18 slanting orientations. A rapid and scalable laser direct writing method realizes LIG patterning in both the in-plane and out-of-plane configurations as well as the formation of nonstick conductive structures to the liquid metal. By rationally merging the LIG-based tilt, strain, and humidity sensors on a thin flexible film, the multimodal sensor device is applied to a diaper as a real-time feedback tracking system of the sleeping posture, respiration, and wetness toward secure and comfortable lives. User-friendly interfaces, which incorporate alarming functions, provide timely feedback for caregivers tending to vulnerable populations with limited self-care capabilities.

Highly stable Pd/HNb3O8-based flexible humidity sensor for perdurable wireless wearable applications.

Real-time, daily health monitoring can provide large amounts of patient data, which may greatly improve the likelihood of diagnosing health conditions at an early stage. One potential sensor is a flexible humidity sensor to monitor moisture and humidity information such as dehydration. However, achieving a durable functional nanomaterial-based flexible humidity sensor remains a challenge due to partial desorption of water molecules during the recovery process, especially at high humidities. In this work, we demonstrate a highly stable resistive-type Pd/HNb3O8 humidity sensor, which exhibits a perdurable performance for over 100 h of cycle tests under a 90% relative humidity (RH) without significant performance degradation. One notable advantage of the Pd/HNb3O8 humidity sensor is its ability to regulate hydroniums due to the strong reducibility of H atoms dissociated on the Pd surface. This feature realizes a high stability even at a high humidity (99.9% RH). Using this superior performance, the Pd/HNb3O8 humidity sensor realizes wireless monitoring of the changes in the fingertip humidity of an adult under different physiological states, demonstrating a facile and reliable path for dehydration diagnosis.

Multimodal Plant Healthcare Flexible Sensor System.

The rising global human population and increased environmental stresses require a higher plant productivity while balancing the ecosystem using advanced nanoelectronic technologies. Although multifunctional wearable devices have played distinct roles in human healthcare monitoring and disease diagnosis, probing potential physiological health issues in plants poses a formidable challenge due to their biological complexity. Herein an integrated multimodal flexible sensor system is proposed for plant growth management using stacked ZnIn2S4(ZIS) nanosheets as the kernel sensing media. The proposed ZIS-based flexible sensor can not only perceive light illumination at a fast response (∼4 ms) but also monitor the humidity with a perdurable steady performance that has yet to be reported elsewhere. First-principles calculations reveal that the tunneling effect dominates the current model associated with humidity response. This finding guides the investigation on the plant stomatal functions by measuring plant transpiration. Significantly, dehydration conditions are visually recorded during a monitoring period (>15 days). This work may contribute to plant-machine biointerfaces to precisely manage plant health status and judiciously utilize limited resources.

Highly Precise Multifunctional Thermal Management-Based Flexible Sensing Sheets.

Elaborate manipulation of heat transfer renders proper operation of diverse thermal-related technologies. However, accurate implementation of thermal-based or transduction sensing on a thin flexible film over unusual surfaces remains challenging. Herein, efficient thermal management realizes highly accurate flexible multifunctional sensor sheets using a low thermal conductive medium as a thermal barrier. An approximately 50-fold enhancement in the thermal sensing accuracy, which is nearly independent of the changes in the external surroundings, is achieved. Such rational control of heat convection and conduction allows to not only dynamically monitor air flow, but also sight the large-scale air flow distribution on curved surfaces using a flexible thermal flow sensor array. Additionally, accurate wearable skin temperature monitoring independent of the sudden surrounding variations is achieved. This work addresses the formidable challenge of untethered heat transfer induced imprecise thermal related sensing, which universally exists in skin-inspired Internet of Things (IoT) applications.

Femtosecond Laser Fabricated Elastomeric Superhydrophobic Surface with Stretching-Enhanced Water Repellency.

Highly stretchable and robust superhydrophobic surfaces have attracted tremendous interest due to their broad application prospects. In this work, silicone elastomers were chosen to fabricate superhydrophobic surfaces with femtosecond laser texturing method, and high stretchability and tunable adhesion of the superhydrophobic surfaces were demonstrated successfully. To our best knowledge, it is the first time flexible superhydrophobic surfaces with a bearable strain up to 400% are fabricated by simple laser ablation. The test also shows that the strain brings no decline of water repellency but an enhancement to the superhydrophobic surfaces. In addition, a stretching-induced transition from "petal" state to "lotus" state of the laser-textured surface was also demonstrated by non-loss transportation of liquid droplets. Our results manifest that femtosecond laser ablating silicone elastomer could be a promising way for fabricating superhydrophobic surface with distinct merits of high stretchability, tunable adhesion, robustness, and non-fluorination, which is potentially useful for microfluidics, biomedicine, and liquid repellent skin.

Toward Flexible Surface-Enhanced Raman Scattering (SERS) Sensors for Point-of-Care Diagnostics.

Surface-enhanced Raman scattering (SERS) spectroscopy provides a noninvasive and highly sensitive route for fingerprint and label-free detection of a wide range of molecules. Recently, flexible SERS has attracted increasingly tremendous research interest due to its unique advantages compared to rigid substrate-based SERS. Here, the latest advances in flexible substrate-based SERS diagnostic devices are investigated in-depth. First, the intriguing prospect of point-of-care diagnostics is briefly described, followed by an introduction to the cutting-edge SERS technique. Then, the focus is moved from conventional rigid substrate-based SERS to the emerging flexible SERS technique. The main part of this report highlights the recent three categories of flexible SERS substrates, including actively tunable SERS, swab-sampling strategy, and the in situ SERS detection approach. Furthermore, other promising means of flexible SERS are also introduced. The flexible SERS substrates with low-cost, batch-fabrication, and easy-to-operate characteristics can be integrated into portable Raman spectroscopes for point-of-care diagnostics, which are conceivable to penetrate global markets and households as next-generation wearable sensors in the near future.

Nanophotonic-Engineered Photothermal Harnessing for Waste Heat Management and Pyroelectric Generation.

At present, there are various limitations to harvesting ambient waste heat which include the lack of economically viable material and innovative design features that can efficiently recover low grade heat for useful energy conversion. In this work, a thermal nanophotonic-pyroelectric (TNPh-pyro) scheme consisting of a metamaterial multilayer and pyroelectric material, which performs synergistic waste heat rejection and photothermal heat-to-electricity conversion, is presented. Unlike any other pyroelectric configuration, this conceptual design deviates from the conventional by deliberately employing back-reflecting NIR to enable waste heat reutilization/recuperation to enhance pyroelectric generation, avoiding excessive solar heat uptake and also retaining high visual transparency of the device. Passive solar reflective cooling up to 4.1 °C is demonstrated. Meanwhile, the photothermal pyroelectric performance capitalizing on the back-reflecting effect shows an open circuit voltage (Voc) and short circuit current (Isc) enhancement of 152 and 146%, respectively. In addition, the designed photoactive component (TiO2/Cu) within the metamaterial multilayer provides the TNPh-pyro system with an effective air pollutant photodegradation functionality. Finally, proof-of-concept for concurrent photothermal management and enhanced solar pyroelectric generation under a real outdoor environment is demonstrated.

Ag-CuO-ZnO metal-semiconductor multiconcentric nanotubes for achieving superior and perdurable photodegradation.

Solar energy represents a robust and natural form of resource for environment remediation via photocatalytic pollutant degradation with minimum associated costs. However, due to the complexity of the photodegradation process, it has been a long-standing challenge to develop reliable photocatalytic systems with low recombination rates, excellent recyclability, and high utilization rates of solar energy, especially in the visible light range. In this work, a ternary hetero-nanostructured Ag-CuO-ZnO nanotube (NT) composite is fabricated via facile and low-temperature chemical and photochemical deposition methods. Under visible light irradiation, the as-synthesized ZnO NT based ternary composite exhibits a greater enhancement (∼300%) of photocatalytic activity than its counterpart, Ag-CuO-ZnO nanorods (NRs), in pollutant degradation. The enhanced photocatalytic capability is primarily attributed to the intensified visible light harvesting, efficient charge carrier separation and much larger surface area. Furthermore, our as-synthesised hybrid ternary Ag-CuO-ZnO NT composite demonstrates much higher photostability and retains ∼98% of degradation efficiency even after 20 usage cycles, which can be mainly ascribed to the more stable polar planes of ZnO NTs than those of ZnO NRs. These results afford a new route to construct ternary heterostructured composites with perdurable performance in sewage treatment and photocorrosion suppression.

Uniaxially Stretched Flexible Surface Plasmon Resonance Film for Versatile Surface Enhanced Raman Scattering Diagnostics.

Surface-enhanced Raman scattering (SERS) spectroscopy affords a rapid, highly sensitive, and nondestructive approach for label-free and fingerprint diagnosis of a wide range of chemicals. It is of great significance to develop large-area, uniform, and environmentally friendly SERS substrates for in situ identification of analytes on complex topological surfaces. In this work, we demonstrate a biodegradable flexible SERS film via irreversibly and longitudinally stretching metal deposited biocompatible poly(ε-caprolactone) film. This composite film after stretching shows surprising phenomena: three-dimensional and periodic wave-shaped microribbons array embedded with a high density of nanogaps functioning as hot-spots at an average gap size of 20 nm and nanogrooves array along the stretching direction. The stretched polymer surface plasmon resonance film gives rise to more than 10 times signal enhancement in comparison with that of the unstretched composite film. Furthermore, the SERS signals with high uniformity exhibit good temperature stability. The polymer SPR film with excellent flexibility and transparency can be conformally attached onto arbitrary nonplanar surfaces for in situ detection of various chemicals. Our results pave a new way for next-generation flexible SERS detection means, as well as enabling its huge potentials toward green wearable devices for point-of-care diagnostics.