Anterior Transarticular Crossing Screw Fixation for Atlantoaxial Joint Instability: A Biomechanical Study.

OBJECTIVE: To evaluate the biomechanical stability of anterior transarticular crossing screw (ATCS) and compare it with anterior transarticular screw (ATS) which may provide basic evidence for clinical application. METHODS: Eight human fresh cadaveric specimens (occiput-C4) were tested with 5 conditions including the intact status, the injury status (type II odontoid fracture), the injury+ATS fixation status (traditional bilateral ATS fixation); the injury+unilateral ATCS fixation status; and the injury+bilateral ATCS fixation status. Specimens were applied to a pure moment of 1.5 Nm in flexion-extension, lateral bending, and axial rotation, respectively. The range of motions (ROMs) and the neutral zones (NZs) of C1 to C2 segment were calculated and compared between 5 status. RESULTS: ATS and ATCS fixations significantly reduced the motions in all directions when compared with the intact and injury statues (p < 0.05). In flexion-extension, the ROMs of ATS, unilateral ATCS, and bilateral ATCS were 4.7° ± 2.5°, 4.1° ± 1.9°, and 3.2° ± 1.2°, respectively. Bilateral ATCS resulted in a significant decrease in ROM in flexion-extension when compared with ATS and unilateral ATCS (p = 0.035 and p = 0.023). In lateral bending and axial rotation, there was no significant difference in ROM between the 3 fixations (p > 0.05). Three fixations resulted in similar NZs in all directions (p > 0.05). CONCLUSION: ATCS is a biomechanically effective alternative or supplemental method for atlantoaxial instability.

The Morphological Evaluation of the Cervical Muscle in Patients With Basilar Invagination: A Magnetic Resonance Imaging-Based Study.

OBJECTIVE: To investigate the characteristics of functional muscle and muscle size in patients with basilar invagination (BI) and explore the effects of atlantoaxial dislocation. METHODS: Eighty BI patients (BI group) and 80 age- and sex-matched asymptomatic people (control group) were included. Axial T2 magnetic resonance imaging image was used to measure the cross-sectional area (CSA) and functional CSA (FCSA). The sternocleidomastoid (SCM), longus capitis and longus colli (LCap & LC), trapezius (Trap), splenius capitis (SpCap), splenius cervicis (SpC), semispinalis capitis (SSCap), semispinalis cervicis (SSC), multifidus (MS), levator scapulae (LS) and posterior deep layer muscles (PDLM) were evaluated. Correlations between age, atlantodental interval (ADI), Chamberlain distance and muscles were observed. RESULTS: BI group (39.4 ± 18.4 years; 33 males/47 females) exhibited significantly lower FCSA/CSA ratios than the control group in all extensor and flexor muscles, and presented smaller CSAs on the right and left Trap, SSC, LS, SCM, and left LCap & LC. FCSA/CSA ratios were significantly lower in BI patients with dislocation on the right Trap, SpCap, SpC, SSCap, MS, LS, LCap & LC, and PDLM, and the left SSCap, MS, and LCap & LC than in patients without deformity. Additionally, functional muscles of all parameters decreased with age in BI patients. Excluding children, the Trap, SpC, MS, and LS muscle sizes of BI patients tended to increase with age. ADI and Chamberlain distance tended to correlate negatively with FCSA/CSA ratio. CONCLUSION: The BI patients, especially those with atlantoaxial dislocation, had less functional muscles compared with the control group. Moreover, their functional muscles decreased with age more obviously.

Feasibility of C2 Pedicle Screw Fixation with the "in-out-in" Technique for Patients with Basilar Invagination.

STUDY DESIGN: Retrospective study. OBJECTIVE: To evaluate the feasibility of C2 pedicle screw (C2PS) fixation with the "in-out-in" technique in patients with basilar invagination (BI). SUMMARY OF BACKGROUND DATA: The "in-out-in" technique is a fixation technique in which the screw enters the vertebrae through the parapedicle. The technique has been used in upper cervical spine fixation. However, anatomic parameters associated with the application of this technique in patients with BI are unclear. METHODS: We measured the C2 pedicle width (PW), the distance between vertebral artery (VA) and the transverse foramen (VATF), the safe zone and the limit zone. The lateral safe zone is the distance from the medial/lateral cortex of the C2 pedicle to the VA (LPVA/MPVA), and the medial safe zone is the distance from the medial/lateral cortex of the C2 pedicle to the dura (MPD/LPD). The lateral limit zone is the sum of LPVA/MPVA and VATF (LPTF/MPTF), and the medial limit zone is the distance from the medial/lateral cortex of the C2 pedicle to the spinal cord (MPSC/LPSC). PW, LPVA, MPVA and VATF were measured on the reconstructed CT angiography. PW, MPD, LPD, MPSC and LPSC were measured on MRI. We define a width greater than 4 mm as safe for screw. The t-test was used to compare the parameters between male and female, left and right sides in all patients, and PW in CTA and MRI data in the same patient. For intrarater reliabilities, interclass correlation coefficients were calculated. RESULTS: A total of 154 patients (49 CTA, 143 MRI) were included. The average PW, LPVA, MPVA, LPTF, MPTF, MPD, LPD, MPSC and LPSC were 5.30 mm, 1.28 mm, 6.60 mm, 2.45 mm, 8.94 mm, 2.09 mm, 7.07 mm, 5.51 mm and 10.48 mm, respectively. Furthermore, in patients with PW ˂4 mm, 53.6% of MPVA, 86.2% of LPTF, and all limit zones were larger than 4 mm. CONCLUSIONS: In patients with basilar invagination, there is sufficient space medially and laterally to the C2 pedicle for partial screw encroachment to achieve "in-out-in" fixation, even if the pedicle is small. LEVEL OF EVIDENCE: 4.

Anterior atlanto-occipital transarticular screw fixation: a biomechanical comparison with posterior fixation techniques.

OBJECTIVE: Atlanto-occipital instability is commonly treated with posterior fixation. However, in patients with congenital or acquired factors, posterior fixation may not be possible. For these situations, a novel anterior atlanto-occipital transarticular screw (AATS) fixation technique has been introduced recently. However, biomechanical study of this technique is lacking. This study was designed to evaluate the biomechanical stability of AATS fixation for the atlanto-occipital joint and compare it with conventional posterior occipitocervical fixation (POCF). METHODS: Six cadaveric specimens (occiput-C4) were tested in four conditions, including intact, injury, injury + AATS, and injury + POCF states. A pure moment of 1.5 Nm was applied to specimens in flexion, extension, lateral bending, and axial rotation. The range of motion (ROM) and neutral zone (NZ) were calculated and compared from the occiput to C1. RESULTS: The AATS fixation constrained ROMs to 0.4° in flexion (p < 0.001), 0.4° in extension (p < 0.001), 1.0° in lateral bending (p < 0.001), and 0.7° in axial rotation (p < 0.001) when compared with the injury state. In all directions, there was no statistically significant difference observed in ROMs and NZs between AATS fixation and POCF (p > 0.05). CONCLUSIONS: This study identified that the novel AATS fixation, as stand-alone anterior fixation, was equivalent to POCF in all directions. The results suggest that anterior transarticular screw fixation is a biomechanically effective salvage technique for posterior atlanto-occipital fixation, and may also serve as supplemental fixation.