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1.
Clin Cosmet Investig Dermatol ; 17: 1603-1612, 2024.
Artigo em Inglês | MEDLINE | ID: mdl-38984321

RESUMO

Alopecia is considered a widespread yet troubling health issue, with limited treatment options. As membranous structures derived from cells carrying proteins, nucleic acids and lipids, exosomes functionally medicate intercellular communication and alter the responses of recipient cells, resulting in disease restraint or promotion. Exosomes have broad prospects in diagnosis and treatment of diseases. Studies using animal models and at the cellular level have clearly shown that exosomes from several types of cells, including dermal papilla cells and mesenchymal stem cells, have a notable capacity to promote hair growth, suggesting that exosomes may provide a new option to treat alopecia. Here, we present a thorough review of the most recent progress in the application of exosomes to hair growth.

4.
J Cosmet Dermatol ; 20(9): 2765-2768, 2021 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-33356001

RESUMO

BACKGROUND: There is an increasing demand for fat reduction and body contouring procedures. Noninvasive radiofrequency devices have been used to tighten skin and treat cellulite, but there are few studies confirming their efficacy for abdominal fat reduction. OBJECTIVE: This study explored the effects of four noninvasive radiofrequency (RF) treatments on abdominal fat in Asian subjects, evaluating body weight, body mass index (BMI), and waist circumference. METHODS: In this study, 16 patients with abdominal obesity were treated four times with a noninvasive and contactless selective RF device (VANQUISH ME™, BTL Aesthetics). Treatments were 7 days apart and lasted 45 min each. The BMI and circumference of the upper, middle, and lower abdomen were measured at baseline and after each treatment. RESULTS: There were statistically significant reductions in BMI and abdominal circumference in all 16 patients (P < .05). Most patients only experienced a slight abdominal heat sensation and minimal body sweating during the treatment, and no adverse reactions were observed after the treatment. CONCLUSION: The noninvasive and contactless selective RF technique was effective and safe in reducing fat, BMI, and abdominal circumference.


Assuntos
Celulite , Técnicas Cosméticas , Terapia por Radiofrequência , Gordura Abdominal , Humanos , Gordura Subcutânea Abdominal
5.
J Cosmet Dermatol ; 20(3): 884-889, 2021 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-32783330

RESUMO

BACKGROUND: Infraorbital dark circles (DC) are defined as a symptom that presents darkness under infraorbital eyelids. The objective of this study was to evaluate the efficacy and safety of nano-microneedle-assisted phenylethyl resorcinol (PR) for the treatment of infraorbital dark circles. METHODS: Twenty female participants were randomized to two groups. In the experimental group (group E), participants received topical PR gel under the left orbit once a day and topical plus nano-microneedle-assisted PR gel under the right orbit twice a week. In the control group (group C), participants were treated with gel without PR. Melanin index (MI) and erythema index (EI) were measured before the session (T0), 4 and 8 weeks during the treatment session (T4, T8), and 1 and 2 months after the last session (T12, T16). The global assessment was performed by a blinded dermatologist. RESULTS: The mean value of MI in group E was significantly lower than the baseline at T8 (P < .05), and the right side decreased more significantly than the left side (P < .05). However, there was no difference of MI before and after treatment in group C (P > .05). There was no big difference of the mean EI between the two sides (P > .05). The treatment was well tolerated, and no serious adverse effects were reported. CONCLUSION: PR combined with nano-microneedle could be an effective and safe method for infraorbital DC.


Assuntos
Pálpebras , Órbita , Compostos Benzidrílicos , Feminino , Humanos , Agulhas , Resorcinóis , Resultado do Tratamento
8.
J Dermatol ; 46(2): 158-160, 2019 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-30549102

RESUMO

We report a 21-year-old man with recurrent bullous eruptions and severe itching on the lower legs and feet since 5 years of age. Dry, dirty brown, tile-like scales covered his lower legs with dystrophic toenails. Nodular prurigo-like lesions, scarring papules and milia remitted after the bullous eruptions. His father and another two family members had similar but mild presentations with recurrent bullae on the lower legs. Whole exome sequencing detected the heterozygous variants of COL7A1 c.6698G>A and FLG c.7249C>T in this pedigree. COL7A1 c.6698G>A was reported in bullous dermolysis of the newborn and FLG c.7249C>T was reported in ichthyosis vulgaris. Thus, the diagnosis of dystrophic epidermolysis bullosa pruriginosa associated with ichthyosis vulgaris was made.


Assuntos
Colágeno Tipo VII/genética , Epidermólise Bolhosa Distrófica/genética , Ictiose Vulgar/genética , Proteínas de Filamentos Intermediários/genética , Epidermólise Bolhosa Distrófica/complicações , Epidermólise Bolhosa Distrófica/diagnóstico , Proteínas Filagrinas , Humanos , Ictiose Vulgar/complicações , Ictiose Vulgar/diagnóstico , Masculino , Mutação Puntual , Sequenciamento do Exoma , Adulto Jovem
9.
Regen Med ; 13(6): 729-739, 2018 09.
Artigo em Inglês | MEDLINE | ID: mdl-30255731

RESUMO

Wound-induced hair follicle neogenesis (WIHN) is a regenerative phenomenon that occurs widely in the skin of adult mammalians. A fully functional follicle can regenerate in the center of a full-thickness wound with a large enough size. The cellular origin of this process is similar to embryonic process. Many growth and development-related pathways are involved in WIHN. Studying WIHN can deeply explore the mechanism of biological growth, development and regeneration, and can identify new treatments for hair-related disorders. Our review aims to enlighten future study by summarizing the clinical manifestation of WIHN, as well as the cellular and molecular mechanism of WIHN in recent studies.


Assuntos
Folículo Piloso/fisiopatologia , Medicina Regenerativa , Animais , Fibroblastos/metabolismo , Fibroblastos/fisiologia , Folículo Piloso/crescimento & desenvolvimento , Proteínas Hedgehog/metabolismo , Proteínas Hedgehog/fisiologia , Interleucina-6/genética , Interleucina-6/metabolismo , Interleucina-6/fisiologia , Camundongos , Camundongos Knockout , Fator de Transcrição STAT3/metabolismo , Fator de Transcrição STAT3/fisiologia , Transdução de Sinais
11.
Biotechnol Lett ; 40(6): 1009-1014, 2018 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-29713847

RESUMO

OBJECTIVES: To explore potential effects of recombinant human fibroblast growth factor 20 (rhFGF20) in the growth of cultured mouse vibrissal follicles. RESULTS: The growth of cultured mouse vibrissal follicles was significantly induced by rhFGF20 in a dose dependent pattern in the in vitro vibrissal follicle organ culture model. However, too high concentration of rhFGF20 could inhibit the growth of vibrissal follicles. We further demonstrated that rhFGF20 stimulated the proliferation of hair matrix cells and activated Wnt/ß-catenin signaling pathway. CONCLUSIONS: The rhFGF20 might be a potential therapeutic agent to treat hair loss disorders.


Assuntos
Fatores de Crescimento de Fibroblastos/farmacologia , Folículo Piloso/efeitos dos fármacos , Proteínas Recombinantes/farmacologia , Vibrissas/efeitos dos fármacos , Animais , Proliferação de Células/efeitos dos fármacos , Feminino , Folículo Piloso/citologia , Folículo Piloso/metabolismo , Humanos , Camundongos , Camundongos Endogâmicos C57BL , Técnicas de Cultura de Tecidos , Regulação para Cima/efeitos dos fármacos , Vibrissas/citologia , Vibrissas/metabolismo , Via de Sinalização Wnt/efeitos dos fármacos
12.
Acta Derm Venereol ; 98(3): 318-323, 2018 Mar 13.
Artigo em Inglês | MEDLINE | ID: mdl-29136266

RESUMO

Prostanoids, including prostaglandins (PGs) and thromboxane A2 (TXA2), are a family of lipid-derived autacoids that modulate many physiological systems and pathological contexts. Prostanoids are generated by sequential metabolism of arachidonic acid, catalysed by cyclo-oxygenase, to PGH2, which is then converted to PGD2, PGE2, PGF2α, PGI2 and TXA2, catalysed by their specific synthases. Recent evidence suggests that prostanoids play a role in regulating hair growth. The PGF2α analogue is Food and Drug Administration-approved in the US and routinely used to enhance the growth of human eyelashes. PGE2 is reported to protect from radiation-induced hair loss in mice. Conversely, PGD2 inhibits hair growth. This paper reviews the metabolism of prostanoids and the expression pattern of prostanoid receptors in hair follicles, focussing on their different and opposing effects on hair growth and the underlying mechanisms. This has potential clinical relevance in the treatment and prevention of hair disorders.


Assuntos
Doenças do Cabelo/metabolismo , Folículo Piloso/metabolismo , Prostaglandinas/metabolismo , Regeneração , Animais , Doenças do Cabelo/tratamento farmacológico , Doenças do Cabelo/fisiopatologia , Folículo Piloso/efeitos dos fármacos , Folículo Piloso/crescimento & desenvolvimento , Humanos , Receptores de Prostaglandina/metabolismo , Regeneração/efeitos dos fármacos , Transdução de Sinais
14.
J Cosmet Laser Ther ; 19(1): 13-17, 2017 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-27594596

RESUMO

BACKGROUND: Melasma is the most common and distressing pigmentary disorder presenting to dermatology clinics. Various treatment protocols for melasma have been suggested in the previous literature and applied in various clinical settings. However, no satisfactory therapy has been widely accepted. OBJECTIVE: To evaluate the efficiency and safety of a combination treatment with fractional Q-switched ruby laser (QSRL) and intense pulsed light (IPL) for melasma in Chinese population. METHODS: Fifty-three Chinese melasma patients were enrolled in this study. Each patient underwent 2 courses of treatments at 2-week interval. One course was composed of 3 successive sessions of 694-nm fractional QSRL at intervals of two weeks followed by one IPL. The efficacy was evaluated by non-invasive measurements and subjective assessments. The adverse effects were recorded. RESULTS: Mean melanin index (MI) and erythema index (EI) significantly decreased from 216.1 and 381.8 pre-treatment to 167.8 and 310.3 post-treatment, respectively. Mean melasma area and severity index (MASI) decreased dramatically from 14.66 before treatment to 5.70 after the final treatment. These values remained at low levels at 3-month follow-up. The percentage of patients who achieved moderate or significant improvements was 73.6%. Adverse effects of QSRL and IPL were minimal. CONCLUSION: The combination treatment of fractional QSRL and IPL would be a promising modality for managing melasma in Chinese patients.


Assuntos
Terapia de Luz Pulsada Intensa , Lasers de Estado Sólido/uso terapêutico , Melanose/terapia , Adulto , China , Terapia Combinada , Feminino , Humanos , Terapia de Luz Pulsada Intensa/efeitos adversos , Lasers de Estado Sólido/efeitos adversos , Pessoa de Meia-Idade , Índice de Gravidade de Doença , Resultado do Tratamento , Adulto Jovem
16.
J Drugs Dermatol ; 14(11): 1336-40, 2015 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-26580884

RESUMO

BACKGROUND: Although pulsed dye laser (PDL) has long been regarded as the gold standard in treating port-wine stain (PWS), advanced PWS with deeper coloration may display resistance because of limited penetration depth of 585 or 595-nm light. Recently, a dual-wavelength laser system has been reported to achieve pronounced fading in many patients. OBJECTIVE: The objective was to evaluate the efficacy and safety of a dual-wavelength laser device in treatment of neck and facial PWS in a direct side-by-side comparison. METHODS: Sixteen Chinese patients with neck and/or facial PWSs were enrolled in the study. All lesions were randomly divided into two area, treated area and adjacent untreated area. Five successive treatments using a dual-wavelength laser system (595-nm PDL combined with 1,064-nm Nd:YAG laser) were delivered on treated areas at 4- to 6-week intervals. The adjacent area was not treated as self control. Two blinded dermatologists evaluated the clinical changes by comparing the before and after photos. Erythema index (EI) values were measured with a non-invasive instrument. RESULTS: After five sessions of treatment, over 62.5% (10/16) patients achieved more than 50% (moderate or significant) improvement. The efficacy maintained at the 3-month follow-up visit. The values of EI on treated area showed a significant decrease. Adverse effects of treated area were limited. CONCLUSION: Using this split-face module, the dual-wavelength laser system is proved to be effective and well tolerated in treating neck and facial PWSs in Chinese patients. Adverse effects were minimal and acceptable.


Assuntos
Lasers de Corante/uso terapêutico , Lasers de Estado Sólido/uso terapêutico , Mancha Vinho do Porto/radioterapia , Adolescente , Adulto , Povo Asiático , Eritema/epidemiologia , Face , Feminino , Seguimentos , Humanos , Lasers de Corante/efeitos adversos , Lasers de Estado Sólido/efeitos adversos , Masculino , Pescoço , Mancha Vinho do Porto/patologia , Resultado do Tratamento , Adulto Jovem
18.
Mol Carcinog ; 54(11): 1340-53, 2015 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-25175281

RESUMO

Hemangioendotheliomas could be repressed by various anti-angiogenic agents in animal models. It was unclear whether the agents target hemangioendothelioma cells directly. This study elucidated the mechanism by which endostatin inhibited hemangioendothelioma progression. Expression of the endostatin receptors nucleolin and integrin α5ß1 in hemangioendothelioma was assessed by immunohistochemistry. The effects of endostatin on the hemangioendothelioma-derived cells (EOMA) were evaluated by proliferation and apoptosis assays and by angiogenesis array screening. This revealed the contribution of the Chemokine (C-X-C motif) ligand 1 (CXCL1) to hemangioendothelioma progression, which was explored in vitro and in vivo. The clinical relevance of CXCL1 expression in hemangioendothelioma was also evaluated using tissue array. EOMA cells expressed nucleolin and integrin α5ß1 and bound to endostatin. Endostatin did not alter proliferation or hypoxia-induced apoptosis in EOMA cells but it did impair the pro-angiogenic capacity of the cells. Endothelial cell migration was induced by CXCL1 produced by EOMA cells and endostatin downregulated CXCL1 production by inactivating its transcriptional factor, nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB). In vivo, the knockdown of CXCL1 significantly impaired EOMA cell growth in nude mice; endostatin had no effect when CXCL1 was overexpressed. A strong correlation was observed between CXCL1 levels and hemangioendothelioma occurrence in patients. CXCL1, which was responsible for hemangioendothelioma progression by stimulating angiogenesis, was impaired by endostatin via inactivation of NF-κB in an animal model. In vascular lesions in patients, CXCL1 expression was a negative prognostic factor. CXCL1-inhibting agents such as endostatin may constitute a useful approach to treat the malignant or intermediate vascular lesions.


Assuntos
Carcinogênese/efeitos dos fármacos , Quimiocina CXCL1/genética , Regulação para Baixo/efeitos dos fármacos , Endostatinas/farmacologia , Hemangioendotelioma/tratamento farmacológico , Inibidores da Angiogênese/farmacologia , Animais , Apoptose/efeitos dos fármacos , Apoptose/genética , Carcinogênese/genética , Movimento Celular/efeitos dos fármacos , Movimento Celular/genética , Proliferação de Células/efeitos dos fármacos , Proliferação de Células/genética , Regulação para Baixo/genética , Feminino , Hemangioendotelioma/genética , Humanos , Integrina alfa5beta1/genética , Camundongos , Camundongos Nus , NF-kappa B/genética , Neovascularização Patológica/tratamento farmacológico , Neovascularização Patológica/genética , Fosfoproteínas/genética , Proteínas de Ligação a RNA/genética , Nucleolina
20.
J Drugs Dermatol ; 12(4): 464-8, 2013 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-23652896

RESUMO

OBJECTIVE: The objective of the study was to investigate whether a topical antioxidant complex containing vitamins C and E and ferulic acid can protect solar-simulated ultraviolet irradiation (ssUVR)-induced acute photodamage in human skin. METHOD: Twelve healthy female Chinese subjects were enrolled in this study. Four unexposed sites on dorsal skin were marked for the experiment. The products containing antioxidant complex and vehicle were applied onto 2 sites, respectively, for 4 consecutive days. On day 4, the antioxidant complex-treated site, the vehicle-treated site, and the untreated site (positive control) received ssUVR (5 times the minimal erythema dose). The fourth site (negative control) received neither ssUVR nor treatment. Digital photographs were taken, and skin color was measured pre- and postirradiation. Skin biopsies were obtained 24 hours after exposure to ssUVR, for hematoxylin and eosin and immunohistochemical staining. RESULTS: A single, 5 times the minimal erythema dose of ssUVR substantially induced large amounts of sunburn cell formation, thymine dimer formation, overexpression of p53 protein, and depletion of CD1a+ Langerhans cells. The antioxidant complex containing vitamins C and E and ferulic acid conferred significant protection against biological events compared with other irradiated sites. CONCLUSION: A topical antioxidant complex containing vitamins C and E and ferulic acid has potential photoprotective effects against ssUVR-induced acute photodamage in human skin.


Assuntos
Antioxidantes/farmacologia , Eritema/prevenção & controle , Pele/efeitos dos fármacos , Raios Ultravioleta/efeitos adversos , Administração Cutânea , Adolescente , Adulto , Antioxidantes/administração & dosagem , Ácido Ascórbico/administração & dosagem , Ácido Ascórbico/farmacologia , China , Ácidos Cumáricos/administração & dosagem , Ácidos Cumáricos/farmacologia , Combinação de Medicamentos , Eritema/etiologia , Feminino , Humanos , Pessoa de Meia-Idade , Estresse Oxidativo/efeitos dos fármacos , Pele/patologia , Pele/efeitos da radiação , Queimadura Solar/patologia , Queimadura Solar/prevenção & controle , Resultado do Tratamento , Vitamina E/administração & dosagem , Vitamina E/farmacologia , Adulto Jovem
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