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1.
Zhongguo Zhong Yao Za Zhi ; 49(9): 2441-2450, 2024 May.
Artigo em Chinês | MEDLINE | ID: mdl-38812143

RESUMO

This study aims to explore the correlation between intestinal toxicity and composition changes of Euphorbia ebracteolata before and after Terminalia chebula soup(TCS) processing. Intragastric administration was performed on the whole animal model. By using fecal water content, inflammatory causes, and pathological damage of different parts of the intestinal tract of mice as indexes, the differences in intestinal toxicity of dichloromethane extraction of raw E. ebracteolata(REDE), dichloromethane extraction of TCS, and dichloromethane extraction of E. ebracteolata after simulated TCS processing(STREDE) were compared, so as to investigate the effect of TCS processing on the intestinal toxicity of E. ebracteolata. At the same time, the component databases of E. ebracteolata and T. chebula were constructed, and the composition changes of diterpenoids, tannins, and phenolic acids in the three extracted parts were analyzed by HPLC-TOF-MS. HPLC was used to compare the content of four diterpenoids including ent-11α-hydroxyabicta-8(14), 13(15)-dien-16, 12-olide(HAO), jolkinolide B(JNB), fischeria A(FA), and jolkinolide E(JNE) in the E. ebracteolata before and after processing and the residue of container wall after processing, so as to investigate the effect of TCS processing on the content and structure of the diterpenoids. The results showed that the REDE group could significantly increase the fecal water content and the release levels of TNF-α and IL-1ß from each intestinal segment, and intestinal tissue damage was accompanied by significant infiltration of inflammatory cells. However, compared with the REDE group, the intestinal tissue damage in the STREDE group was alleviated, and the infiltration of inflammatory cells decreased. The intestinal toxicity significantly decreased. Mass spectrometry analysis showed that there was no significant difference in the content of diterpenoids of REDE before and after simulated TCS processing, but a large number of tannins and phenolic acids were added. The results of HPLC showed that the content of four diterpenoids of E. ebracteo-lata decreased to varying degrees after TCS processing, ranging from-0.35% to-19.74%, and the decreased part mainly remained in the container wall, indicating that the structure of toxic diterpenoids of E. ebracteolata was not changed after TCS processing. The antagonistic effect of tannic and phenolic acids in the TCS may be the main reason for the reduced intestinal toxicity of E. ebracteolata after TCS processing. The TCS processing for E. ebracteolata is scientific.


Assuntos
Medicamentos de Ervas Chinesas , Euphorbia , Terminalia , Euphorbia/química , Animais , Terminalia/química , Camundongos , Medicamentos de Ervas Chinesas/química , Medicamentos de Ervas Chinesas/toxicidade , Masculino , Intestinos/efeitos dos fármacos , Intestinos/química , Cromatografia Líquida de Alta Pressão , Humanos
2.
Inorg Chem ; 62(23): 8863-8873, 2023 Jun 12.
Artigo em Inglês | MEDLINE | ID: mdl-37262300

RESUMO

Micro-organic pollutants, particularly organic dyes and personal care products (PPCPs), are widely present in wastewater, and thus pose a serious risk to human health. The capture and solar-light photodegradation of micro-organic pollutants are highly challenging tasks, which require the design and synthesis of microporous materials with specific structures. As we know, organic dyes and PPCPs can be absorbed via π-π* stacking. In this paper, an iron-based metal-organic framework (Fe-UiO-68-terNap) containing semirigid conjugated aromatic ligands is prepared for the capture and solar-light photodegradation of multiple water contaminants. UiO-68-terNap was synthesized based on ternaphthalene with π-π* stacking, which would increase the adsorption capacities of organic micropollutants in wastewater. Additionally, the formation of Fe-O-Zr enhances the charge-separation ability resulting in the successful degradation of micropollutants in 240 min. The novel material has been elucidated by single-crystal X-ray diffraction and Fe K-edge XANES, which provide key insights at a molecular level for the design of novel materials for the capture and photodegradation of organic micropollutants.

3.
Inorg Chem ; 56(10): 5748-5756, 2017 May 15.
Artigo em Inglês | MEDLINE | ID: mdl-28430438

RESUMO

Six alkoxohexavanadate-based Cu- or Co-POVs [Cu(dpa)(acac)(H2O)]2[V6O13(OMe)6] (1), [Cu(phen)(acac)(MeOH)]2[V6O13(OMe)6] (2), [Co(dpa)(acac)2]2[V6O13(OMe)6]·2MeOH (3), [Co(phen)(acac)2]2[V6O13(OMe)6] (4), [Cu(dpa)(acac)]2[VIV2VV4O12(OMe)7] (5), and [Cu(dpa)(acac)(MeOH)]2[VIV2VV4O11(OMe)8] (6) (POV = polyoxovanadate; dpa = 2,2'-dipyridine amine; phen = 1,10-phenanthroline; acac = acetylacetone anion) have been synthesized by controlling the reaction conditions and characterized by single-crystal X-ray diffraction and powder X-ray diffraction analyses, FT-IR spectroscopy, element analyses, and X-ray photoelectron spectroscopy. In compounds 1-4 and 6, Cu or Co complexes and alkoxohexavanadate anions are assembled through electrostatic interactions. Differently, in compound 5, seven-methoxo-substituted Lindqvist-type [V6O12(OMe)7]2- are bridged to Cu complex via terminal O atoms by coordination bonds. All compounds 1-6 exhibit excellent heterogeneous catalytic performance in oxidative desulfurization and CEES ((2-chloroethyl) ethyl sulfide, a sulfur mustard simulant) abatement with H2O2 as oxidant. Among them, the catalytic activity of 6 [conv. of DBT (dibenzothiophene) up to 100% in 6 h; conv. of CEES reached 100% and selectivity of CEESO ((2-chloroethyl) ethyl sulfoxide) up to 85% after 4 h] outperforms others and can be reused without losing its activity.

4.
Chem Commun (Camb) ; 52(72): 10846-9, 2016 Sep 18.
Artigo em Inglês | MEDLINE | ID: mdl-27430194

RESUMO

The first sulfur-centered polyanion {SNb8V9.25O45.25} was isolated, which is covalently extended by cobalt complexes into a three-dimensional (3D) architecture. Moreover, the resulting 3D organic-inorganic hybrid compound orders as a weak ferromagnet at low temperature.

5.
Chem Commun (Camb) ; 50(62): 8558-60, 2014 Aug 11.
Artigo em Inglês | MEDLINE | ID: mdl-24955442

RESUMO

A novel bilayer metal-organic framework is assembled with a perfect intralayer triangular subnet and ideal interlayer Td arrangement between unprecedented crown-like Co7 cluster units, exhibiting high spin frustration.

6.
J Hazard Mater ; 165(1-3): 1056-61, 2009 Jun 15.
Artigo em Inglês | MEDLINE | ID: mdl-19070431

RESUMO

Perovskite-type LaFeO(3) and alpha-Fe(2)O(3) with high specific surface areas were directly prepared with appropriate stearic acid-nitrates ratios by a novel stearic acid solution combustion method. The obtained powders were characterized by XRD, FT-IR and XPS techniques. The catalytic activities of perovskite-type LaFeO(3) and alpha-Fe(2)O(3) for the thermal decomposition of octahydro-1,3,5,7-tetranitro-1,3,5,7-tetrazocine (HMX) were investigated by TG and TG-EGA techniques. The experimental results show that the catalytic activity of perovskite-type LaFeO(3) was much higher than that of alpha-Fe(2)O(3) because of higher concentration of surface-adsorbed oxygen (O(ad)) and hydroxyl of LaFeO(3). The study points out a potential way to develop new and more active perovskite-type catalysts for the HMX thermal decomposition.


Assuntos
Azocinas/química , Compostos Férricos/química , Óxidos/química , Catálise , Compostos Férricos/síntese química , Temperatura Alta , Óxidos/síntese química , Pós/química
7.
Dalton Trans ; (47): 6817-24, 2008 Dec 21.
Artigo em Inglês | MEDLINE | ID: mdl-19153629

RESUMO

A flexible ligand bis(7-methyl-1,8-naphthyridine-2-ylamino)methane (), having kappa(4)-chelating and kappa(2)-bridging modes, and its intriguing structural complexes of Zn(II) with mu-OH, kappa(1)-OAc, mu-kappa(1)-OAc and mu-kappa(2)-OAc ligands, [Zn(2)()(2)(OH)](ClO(4))(3) (), [Zn(4)()(2)(OAc)(6)(OH)(2)].CH(2)Cl(2) (.CH(2)Cl(2)) and [Zn(5)()(2)(OAc)(10)](n).4nH(2)O (.4H(2)O) were synthesized and their structures were determined by X-ray crystallography. These compounds exhibited intense blue fluorescent emissions with a lambda(max) in the range of 380-410 nm in CH(2)Cl(2), CH(3)CN and CH(3)OH solutions, and solid-state emissions centered at 416, 463, 490 and 451 nm were observed for the compounds , , and at room temperature, respectively. The investigated fluorescence properties of associated with various metal ions showed that the fluorescence enhancement of with Cd(II) was more sensitive than with other interfering cations.

8.
Inorg Chem ; 46(4): 1171-6, 2007 Feb 19.
Artigo em Inglês | MEDLINE | ID: mdl-17291113

RESUMO

A series of new lanthanide hybrids [Ln3(mu-OH)4 (2,5-pydc)(2,5-Hpydc)3(H2O)4]n (Ln = Gd (1), Dy (2), Er (3), Eu (4), Sm (5), Yb (6), Y (7); 2,5-pydc=pyridine-2,5-dicarboxylate), as clustered lanthanide oxide ring tunnels with helical dodecahedral chains and fully 3D Ln-O-Ln connectivity, has been hydrothermally synthesized and characterized. The inorganic skeleton of the hybrid can be specified by the Schläfli symbol (6210)2 (64102) as a single 3D (3,4)-connected net. The luminescence properties have been studied, and the results showed that the Dy(III) (2) and Eu(III) (4) complexes exhibited sensitized luminescence in the visible region. Variable-temperature magnetic susceptibility measurements of 1-6 showed that the complexes 1-3 are nearly paramagnets, whereas the depopulation of the Stark levels in complexes 4-6 leads to a continuous decrease in mu(eff) when the sample is cooled from 300 to 2 K.


Assuntos
Elementos da Série dos Lantanídeos/síntese química , Lantânio/química , Nanoestruturas/química , Compostos Organometálicos/síntese química , Óxidos/química , Luminescência , Estrutura Molecular , Fotoquímica , Piridinas/química , Análise Espectral , Temperatura
9.
Inorg Chem ; 45(26): 10605-12, 2006 Dec 25.
Artigo em Inglês | MEDLINE | ID: mdl-17173415

RESUMO

Using two ligands, 4,6-bis(2-pyridyl)-2-aminopyrimidine (L1) with two N,N'-chelating sites and 4-(2-pyridyl)-6-(4-pyridyl)-2-aminopyrimidine (L2) (as the isomer of L1) containing one chelating site and one bridging unit, a series of novel Ag(I) complexes varying from zero- to two-dimensions have been prepared and their crystal structures determined via single-crystal X-ray diffraction. The two ligands are employed for the first time in coordination chemistry. The structures of compounds 1-3 are directed by the counteranions adopted in the reaction system: The reaction of L1 with AgNO3 yielded a dimer [Ag2L12](NO3)2 (1). The reaction of L1 with AgCF3SO3 led to a one-dimension "V-shaped" chain {[AgL1](CF3SO3)}n (2). When AgSCN was used, a one-dimension ladder {[Ag2L1(SCN)2].H2O}n (3) was obtained. While ligand L2 reacted with AgNO3, a two-dimension {[Ag2(L2)2](NO3)2.H2O}n (4) was prepared with the help of an argentophilic interaction. Compounds 1-4 display room-temperature photoluminescence.

10.
Artigo em Chinês | MEDLINE | ID: mdl-16027774

RESUMO

OBJECTIVE: To determine the main genotype of hepatitis B virus (HBV) detected from Tibetans in China and provide basic data for hepatitis control and prevention. METHODS: The S gene and C gene were amplified by PCR from the sera of HBsAg positive Tibetans. After sequencing, the gene sequences were analyzed and the phylogenetic trees were drawn by the software MEGA3. RESULTS: In trees based on S gene, the sequences of most samples clustered at genotype D, while in trees based on C gene, the sequences of all samples clustered at genotype C. CONCLUSION: The dominant genotype of HBV detected from Tibetans in China is a C/D hybrid.


Assuntos
Vírus da Hepatite B/genética , Hepatite B/virologia , Genótipo , Hepatite B/sangue , Hepatite B/epidemiologia , Antígenos do Núcleo do Vírus da Hepatite B/genética , Antígenos de Superfície da Hepatite B/sangue , Antígenos de Superfície da Hepatite B/genética , Vírus da Hepatite B/classificação , Vírus da Hepatite B/imunologia , Humanos , Filogenia , Tibet/epidemiologia
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