Instability of Liquid Film with Odd Viscosity over a Non-Uniformly Heated and Corrugated Substrate.

The effect of odd viscosity on the instability of liquid film along a wavy inclined bottom with linear temperature variation is investigated. By utilizing the long-wave approximation, the non-linear evolution equation of the free surface is derived. By applying the normal mode method, the linear instability of thin film flow is investigated. With the help of multi-scale analysis methods, the weakly non-linear instability of thin film flow is also investigated. The results reveal that the Marangoni effect caused by non-uniform temperature distribution promotes the instability of the liquid film, while the odd viscosity has a stabilizing effect. In addition, for a positive local inclination angle θ, an increase in bottom steepness ζ inhibits the instability of the liquid film flow. In contrast, with a negative local inclination angle θ, increased bottom steepness ζ promotes the instability of the liquid film flow. The results of the temporal linear instability analysis and the weakly non-linear instability analysis have been substantiated through numerical simulations of the non-linear evolution equations.

A novel arctigenin-containing latex glove prevents latex allergy by inhibiting type I/IV allergic reactions.

The present study aimed at developing a natural compound with anti-allergic effect and stability under latex glove manufacturing conditions and investigating whether its anti-allergic effect is maintained after its addition into the latex. The effects of nine natural compounds on growth of the RBL-2H3 cells and mouse primary spleen lymphocytes were determined using MTT assay. The compounds included glycyrrhizin, osthole, tetrandrine, tea polyphenol, catechin, arctigenin, oleanolic acid, baicalin and oxymatrine. An ELISA assay was used for the in vitro anti-type I/IV allergy screening; in this process ß-hexosaminidase, histamine, and IL-4 released from RBL-2H3 cell lines and IFN-γ and IL-2 released from mouse primary spleen lymphocytes were taken as screening indices. The physical stability of eight natural compounds and the dissolubility of arctigenin, selected based on the in vitro pharnacodynamaic screening and the stability evaluation, were detected by HPLC. The in vivo pharmacodynamic confirmation of arctigenin and final latex product was evaluated with a passive cutaneous anaphylaxis (PCA) model and an allergen-specific skin response model. Nine natural compounds showed minor growth inhibition on RBL-2H3 cells and mouse primary spleen lymphocytes. Baicalin and arctigenin had the best anti-type I and IV allergic effects among the natural compounds based on the in vitro pharmacodynamic screening. Arctigenin and catechin had the best physical stability under different manufacturing conditions. Arctigenin was the selected for further evaluation and proven to have anti-type I and IV allergic effects in vivo in a dose-dependent manner. The final product of the arctigenin-containing latex glove had anti-type I and IV allergic effects in vivo which were mainly attributed to arctigenin as proved from the dissolubility results. Arctigenin showed anti-type I and IV allergic effects in vitro and in vivo, with a good stability under latex glove manufacturing conditions, and a persistent anti-allergic effect after being added into the latex to prevent latex allergy.