RESUMO
An efficient asymmetric biomimetic transamination of α-keto esters with quinine derivatives as chiral bases was described. A wide variety of α-amino esters containing various functional groups can be synthesized in high yield and enantioselectivity.
Assuntos
Ésteres/química , Aminação , Biomimética , Catálise , Ésteres/metabolismo , Ligação de Hidrogênio , Modelos Moleculares , Estrutura Molecular , Estereoisomerismo , Transaminases/metabolismoRESUMO
A chiral phosphoric acid catalyzed enantioselective bromocyclization of olefins is described. Various cis-, trans-, or trisubstituted γ-hydroxy-alkenes and γ-amino-alkenes can cyclize under the reaction conditions to give optically active 2-substituted tetrahydrofurans and tetrahydropyrroles in up to 91% ee.
RESUMO
A strategy to construct the hexacyclic skeleton of trigonoliimines A, B and their derivatives involving a carbanion-triggered intramolecular cyclization of a seven-membered ring and a subsequent six-membered ring formation in one pot is described.
Assuntos
Alcaloides Indólicos/química , Ciclização , Modelos Moleculares , Estrutura MolecularRESUMO
This paper describes a FeCl(3)/NaI-catalyzed formal allylic C-H oxidation of arylalkenes using a catalytic amount of disulfide with BnOH and 4-nitroaniline as nucleophiles and air as oxidant to form the corresponding allyl ethers and amines. A possible reaction mechanism has been proposed.