RESUMO
One new gentisyl alcohol derivative and-seven known compounds were isolated from the culture of Penicillium sp. Their chemical structures were.elucidated by extensive spectroscopic analysis. Compounds 1, 4, and 6 inhibited Bacillus, subtilis, Staphylococcus aureus, and Escherichia coli with MICs of 32-128 µg/mL.
Assuntos
Liliaceae/microbiologia , Penicillium/química , Antibacterianos/química , Antibacterianos/farmacologia , Bactérias/efeitos dos fármacos , Fermentação , Espectroscopia de Ressonância Magnética , Testes de Sensibilidade Microbiana , Estrutura Molecular , Espectrometria de Massas por Ionização por ElectrosprayRESUMO
One new sesquiterpene was isolated from the fermentation broth of Streptomyces sp. and the structure was elucidated by spectral analysis as caryolane-1, 6beta-diol (1). An intermediate 1alpha, 6beta, 11-eudesmanetriol (2) in the biosynthesis of geosmin was also found in this strain which proved sequence for the reactions, especially bicyclization preceding dealkylation.
Assuntos
Espectroscopia de Ressonância Magnética , Estrutura Molecular , Naftóis , Química , Sesquiterpenos , Química , Streptomyces , QuímicaRESUMO
<p><b>OBJECTIVE</b>[corrected] To study the cyclic peptides from Psammosilene tunicoides.</p><p><b>METHOD</b>The constituents were separated and purified with chromatographic methods, identified by NMR, MS, UV and IR.</p><p><b>RESULT</b>Three cyclic dipeptides: cyclo(-Pro-Val-) (1), cyclo(-Pro-Ala-) (2) and cyclo(-Pro-Pro-) (3), were isolated and identified.</p><p><b>CONCLUSION</b>Compound 1 and 2 are new natural products, compound 3 was isolated for the first time from Psammosilene tunicoides.</p>