RESUMO
A microwave-assisted regioselective synthesis of 3-functionalized indole derivatives via a three-component domino reaction of anilines, arylglyoxal monohydrates, and cyclic 1,3-dicarbonyl compounds is described. The main advantages of this protocol are short reaction times, practical simplicity, its metal-free nature, the availability of starting materials, green solvents, and high regioselectivity.
Assuntos
Indóis/síntese química , Micro-Ondas , Compostos de Anilina/química , Técnicas de Química Sintética , Técnicas de Química Combinatória , Glioxal/químicaRESUMO
A concise, efficient one-pot synthesis of functionalized chromeno[4,3-b]pyridine derivatives via a three-component reaction of 4-oxo-4H-chromene-3-carbaldehydes, malononitrile or cyanoacetates, and aromatic amines under catalyst-free conditions in an environmentally friendly medium (ethanol-water, 3:1 v/v) is described. This synthesis involves a group-assisted purification process, which avoids traditional recrystallization and chromatographic purification methods.
Assuntos
Piridinas/química , Piridinas/síntese química , Técnicas de Química Sintética , Etanol/química , Química Verde , Água/químicaRESUMO
A simple and efficient one-pot construction of pyrazolo[3,4-e]indolizine derivatives via a diethylamine-catalyzed three-component domino reaction of arylglyoxals, cyclic 1,3-diones, and 5-aminopyrazoles under microwave irradiation is described. In this one-pot transformation, seven bonds and two new rings are efficiently formed. This synthesis was confirmed to follow the group-assisted-purification (GAP) chemistry process, which can avoid traditional recrystallization or chromatography purification methods.
Assuntos
Dietilaminas/química , Indolizinas/síntese química , Pirazóis/síntese química , Catálise , Ciclização , Indolizinas/química , Micro-Ondas , Estrutura Molecular , Pirazóis/químicaRESUMO
A concise and efficient three-component domino reaction has been developed for the synthesis of polyfunctionalized indenopyridine and hydroisoquinoline derivatives via the cleavage of a CC bond under transition-metal-free conditions. This reaction provides facile access to complex nitrogen-containing heterocycles by simply mixing three common starting materials in EtOH in the presence of 20 mol % NaOH under microwave irradiation conditions.
Assuntos
Carbono/química , Compostos Heterocíclicos/química , Indenos/química , Nitrogênio/química , Piridinas/química , Micro-Ondas , Estrutura MolecularRESUMO
An efficient synthesis of novel functionalized 1,8-naphthyridine and chromeno[2,3-b]quinoline derivatives via cascade reaction of 2-chloroquinoline-3-carbaldehyde and enaminones or cyclic 1,3-dicarbonyl compounds was developed. All of the 1,8-naphthyridine derivatives synthesized were evaluated for their antiproliferative properties in vitro against cancer cells and several compounds were found to have high activities.
Assuntos
Antineoplásicos/síntese química , Naftiridinas/síntese química , Antineoplásicos/farmacologia , Espectroscopia de Ressonância Magnética , Espectrometria de Massas , Naftiridinas/farmacologia , Difração de Raios XRESUMO
Two series of novel functionalized polyhydroisoquinoline derivatives have been synthesized via the three-component domino reaction of glutaraldehyde and malononitrile with a series of ß-ketoamides under microwave irradiation conditions in the presence of a catalytic amount of Et3N (10 mol%). This reaction represents the first reported process for the facile conversion of a ß-ketoamide to a hydroisoquinoline via a C-N bond cleavage reaction without the need for a multistep reaction process.
Assuntos
Isoquinolinas/síntese química , Amidas/química , Amidas/efeitos da radiação , Catálise , Glutaral/química , Glutaral/efeitos da radiação , Isoquinolinas/química , Micro-Ondas , Nitrilas/química , Nitrilas/efeitos da radiaçãoRESUMO
<p><b>AIM</b>To study the microbial transformation of sinenxan A.</p><p><b>METHODS</b>Choose two strains of Fungi (Mucor spinosus AS 3.3450 and Cunninghamella echinulata AS 3.3400) and a strain of bacterium (Proteus vulgaris AS 1.1208) to transform the substrate.</p><p><b>RESULTS</b>Three products were obtained and identified as 10-deacetylsinenxan A1, 6 alpha-hydroxy-10-deacetylsinenxan A2 and 9 alpha-hydroxy-10-deacetylsinenxan A3 respectively.</p><p><b>CONCLUSION</b>Sinenxan A is facile to be transformed by microorganisms, the 10-acetyl group of which is an active group.</p>