Gaussian beam with high spherical aberration focused by a singlet lens-shaped container for glucose measurements.

We describe a highly sensitive optical technique for glucose concentration measurements in liquid samples based on measuring the heights of the primary sidelobes of the normalized intensity profiles of a focused Gaussian beam with high spherical aberration. A singlet lens-shaped container, filled with the sample under test, is used to focus the beam at an observation plane placed close to the focusing region. The normalized intensity profile of the aberrated beam allows for accurate measurement of the sample glucose concentration.

Gaussian probe beam with high spherical aberration for glucose concentration measurement.

We demonstrate that an optical probe beam with high spherical aberration used for glucose concentration measurements gives better sensitivity compared to a probe beam free of aberrations, under similar conditions. We place a singlet focusing lens at a large distance from a laser source with a Gaussian intensity profile to obtain a spherically aberrated probe beam with negligible truncation. The aberrated probe beam propagates through a transparent liquid sample. Intensity profiles of the transmitted beam are recorded by means of a homodyne profiler to perform the glucose concentration measurements accurately.