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Stem Cell Res ; 66: 102993, 2023 02.
Artigo em Inglês | MEDLINE | ID: mdl-36502622

RESUMO

Schizophrenia (SCZ) and obsessive-compulsive disorder (OCD) are complex polygenic disorders with brain morphology abnormalities. The etiologies and relationship of both disorders remain elusive, and should be further investigated. Thus, induced pluripotent stem cells (iPSCs) were generated from peripheral blood mononuclear cells (PBMCs) from an OCD patient, his mother with SCZ and his healthy father with reprograming method. All iPSCs were characterized to have normal karyotype and expression of pluripotency makers. These iPSCs will be a valuable model to elucidate the pathophysiological mechanisms and association of both diseases.


Assuntos
Células-Tronco Pluripotentes Induzidas , Transtorno Obsessivo-Compulsivo , Esquizofrenia , Feminino , Humanos , Masculino , Esquizofrenia/genética , Esquizofrenia/metabolismo , Mães , Células-Tronco Pluripotentes Induzidas/metabolismo , Leucócitos Mononucleares , Transtorno Obsessivo-Compulsivo/genética , Transtorno Obsessivo-Compulsivo/metabolismo , Pai
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