1.
Org Biomol Chem
; 22(16): 3209-3214, 2024 Apr 24.
Artigo
em Inglês
| MEDLINE
| ID: mdl-38563730
RESUMO
We report a CO-free approach to indole-2-carboxylic esters: rhodium-catalysed C(2)-alkoxycarbonylation of indoles with 2,4,6-trimethylbenzoic acid-based carbonate anhydrides. Selective C-O bond cleavage of the anhydrides facilitates the introduction of various alkoxycarbonyl groups. Control experiments suggest that merging a rhodium catalyst and KI promotes the in situ formation of the RhI species.