Lack of source memory as a potential marker of early assimilation of novel items into current knowledge.

In daily life, humans process a plethora of new information that can be either consistent (familiar) or inconsistent (novel) with prior knowledge. Over time, both types of information can integrate into our accumulated knowledge base via distinct pathways. However, the mnemonic processes supporting the integration of information that is inconsistent with prior knowledge remain under-characterized. In the current study, we used functional magnetic resonance imaging (fMRI) to examine the initial assimilation of novel items into the semantic network. Participants saw three repetitions of adjective-noun word pairs that were either consistent or inconsistent with prior knowledge. Twenty-four hours later, they were presented with the same stimuli again while undergoing fMRI scans. Outside the scanner, participants completed a surprise recognition test. We found that when the episodic context associated with initially inconsistent items was irretrievable, the neural signature of these items was indistinguishable from that of consistent items. In contrast, initially inconsistent items with accessible episodic contexts showed neural signatures that differed from those associated with consistent items. We suggest that, at least one day post encoding, items inconsistent with prior knowledge can show early assimilation into the semantic network only when their episodic contexts become inaccessible during retrieval, thus evoking a sense of familiarity.

Examining the transition of novel information toward familiarity.

Throughout their lives, humans encounter multiple instances of new information that can be inconsistent with prior knowledge (novel). Over time, the once-novel information becomes integrated into their established knowledge base, shifting from novelty to familiarity. In this study, we investigated the processes by which the first steps of this transition take place. We hypothesized that the neural representations of initially novel items gradually change over the course of repeated presentations, expressing a shift toward familiarity. We further assumed that this shift could be traced by examining neural patterns using fMRI. In two experiments, while being scanned, participants read noun-adjective word pairs that were either consistent or inconsistent with their prior knowledge. Stimuli were repeated 3-6 times within the scans. Employing mass univariate and multivariate similarity analyses, we showed that the neural representations associated with the initial presentation of familiar versus novel objects differed in lateral frontal and temporal regions, the medial prefrontal cortex, and the medial temporal lobe. Importantly, the neural representations of novel stimuli gradually changed throughout repetitions until they became indistinguishable from their respective familiar items. We interpret these findings as indicating that an early phase of familiarization can be completed within a few repetitions. This initial familiarization can then serve as the prerequisite to the integration of novel items into existing knowledge. Future empirical and theoretical works can build on the current findings to develop a comprehensive model of the transition from novelty to familiarity.

Metamemory ratings predict long-term changes in reactivated episodic memories.

Reactivation of long-term memory can render the memory item temporarily labile, offering an opportunity to modify it via behavioral or pharmacological intervention. Declarative memory reactivation is accompanied by a metamemory ability to subjectively assess the knowledge available concerning the target item (Feeling of knowing, FOK). We set out to examine whether FOK can predict the extent of change of long-term episodic memories by post-retrieval manipulations. To this end, participants watched a short movie and were immediately thereafter tested on their memory for it. A day later, they were reminded of that movie, and either immediately or 1 day later, were presented with a second movie. The reminder phase consisted of memory cues to which participants were asked to judge their FOK regarding the original movie. The memory performance of participants to whom new information was presented immediately after reactivating the original episode corresponded to the degree of FOK ratings upon reactivation such that the lower their FOK, the less their memory declined. In contrast, no relation was found between FOK and memory strength for those who learned new information 1 day after the reminder phase. Our findings suggest that the subjective accessibility of reactivated memories may determine the extent to which new information might modify those memories.