RESUMO
The article presents data concerning the prevalence, clinical manifestations, methods of diagnostics, treatment and prevention of cholestasis of pregnancy, as well as the case management depending on the gestation and the cholestasis severity. A clinical case of a typical course of cholesrasis of pregnancy is presented.
Assuntos
Colestase , Complicações na Gravidez , Colestase/diagnóstico , Colestase/epidemiologia , Colestase/terapia , Feminino , Humanos , Gravidez , Complicações na Gravidez/diagnóstico , Complicações na Gravidez/epidemiologia , Complicações na Gravidez/terapia , PrevalênciaRESUMO
The purpose of the review is to summarise the current data on chronic and acute pancreatitis with the goal to improve the diagnostics and treatment of women during pregnancy, which complicates differential diagnosis of hepatopancreatobiliary system pathology. The features of the incidence, etiology, parhogenesis and evaluation of the severity of the clinical manifestations of acute pancreatitis in pregnant women are given, It is emphasis that the most frequent its reason is the gallstones following by the biliary pancreatitis. The experience of use in pregnant patients imaging methods - endoscopic ultrasound, magnetic resonance cholangiopancrearography and endoscopic retrograde cholangiopancreatography, as well as treatments that include endoscopic sphincterotomy, stone extraction from the common bile duct and laparoscopic cholecystectomy. The recommendations are based on expert opinions and are not supported by randomized controlled trials. Nevertheless more active clinical management allows to diagnose and treat effectively pancreatitis, including biliary etiology, which contributes to a sharp decline in maternal and perinatal mortality.
Assuntos
Pancreatite/diagnóstico , Pancreatite/terapia , Complicações na Gravidez/diagnóstico , Complicações na Gravidez/terapia , Feminino , Humanos , GravidezRESUMO
Ninety patients with new-onset pulmonary tuberculosis were examined prior to therapy The patients were randomized into 2 groups: 1) 20 patients receiving the standard antibiotic therapy regimen; 2) 70 patients taking the standard antibiotic therapy and the polyenzyme drug Wobenzym. The use of the latter in the complex therapy of patients with pulmonary tuberculosis was shown to cause an increase in the activity of the destructive inflammatory process and to regulate the function of the immune system as compared with those during the standard therapy.
Assuntos
Antituberculosos , Hidrolases , Mycobacterium tuberculosis , Rutina , Tuberculose Pulmonar , Adjuvantes Imunológicos/administração & dosagem , Adjuvantes Imunológicos/efeitos adversos , Adulto , Antituberculosos/administração & dosagem , Antituberculosos/efeitos adversos , Combinação de Medicamentos , Monitoramento de Medicamentos/métodos , Quimioterapia Combinada/métodos , Feminino , Humanos , Hidrolases/administração & dosagem , Hidrolases/efeitos adversos , Interleucina-1beta/sangue , Masculino , Monitorização Imunológica/métodos , Mycobacterium tuberculosis/efeitos dos fármacos , Mycobacterium tuberculosis/imunologia , Rutina/administração & dosagem , Rutina/efeitos adversos , Resultado do Tratamento , Tuberculose Pulmonar/diagnóstico , Tuberculose Pulmonar/tratamento farmacológico , Tuberculose Pulmonar/imunologiaRESUMO
Morphological changes in the liver of pregnant C57Bl/6 mice infected with BCG vaccine before pregnancy and on day 13 of gestation were studied by means of light microscopy and morphometry. The formation of BCG granulomas in mice of both groups was followed by a decrease in the numerical density and diameter of granulomas, increase in the volume density of hepatocyte degeneration and necrosis, and rise in the numerical density of binucleate hepatocytes (compared to nonpregnant mice infected with BCG vaccine).
Assuntos
Granuloma/patologia , Fígado/patologia , Animais , Vacina BCG/efeitos adversos , Feminino , Granuloma/etiologia , Camundongos , Camundongos Endogâmicos C57BL , Microscopia , GravidezRESUMO
Hypotrophy was found in fetuses of female C57Bl/6 mice infected with BCG vaccine. Light microscopy of liver samples revealed destructive processes, impaired reparative regeneration, and fibrosis.
Assuntos
Vacina BCG/efeitos adversos , Cirrose Hepática/etiologia , Cirrose Hepática/patologia , Fígado/patologia , Animais , Feminino , Feto , Camundongos , GravidezRESUMO
Changes in the placentas of pregnant C57Bl/6 mice infected with BCG vaccine were studied by light microscopy and morphometry. The decrease in the numbers of maternal and fetal vessels was paralleled by destructive changes and disorders in the compensatory reactions, which led to fetal hypotrophy after infection with BCG vaccine.