RESUMO
Objective - to assess the changes and the relationship of inflammation markers, adipokine levels and lipid metabolism in overweight and obesity, with signs of the metabolic syndrome. The study involved 62 women aged from 25 to 50 years. Group 1 included women (n=20) with a BMI<27.0, with no signs of metabolic syndrome, group 2 (n=20) - with a BMI>27.0, who were overweight or obese, with no signs of metabolic syndrome, 3 group (n=22) with a BMI>27.0, having overweight or obesity and the presence of any signs of metabolic syndrome. We determined relative and absolute lymphocyte counts and neutrophil granulocytes in the blood, lipid spectrum, blood serum levels of apolipoprotein A-1 (ApoA-1), and apolipoprotein B (apoB), leptin, adiponectin, interleukin-1ß (IL-1ß), interleukin 6 (IL-6), C-reactive protein (CRP). It was noted (p≤0.001) an increase of CRP in the blood of obese women, regardless of the presence of the metabolic syndrome: its concentration in groups 2 and 3 reached 6.69±3.03 and 7.30±3.08 mg/l, respectively, against 2.39±1.66 mg/l in group 1. Increasing BMI was accompanied by (p≤0.01) increase in erythrocyte sedimentation rate (8.1±5.0; 14.3±8.7; 13.9±8.5 mm per hour, respectively, in groups 1, 2 and 3). In women from groups 1 and 3 an increase in triglycerides, accompanied by a decrease in HDL (r=-0.44; p<0.025 and r=-0,57; p<0.001, respectively), and increase of LDL cholesterol (r=1.0; p<0.001) has been shown. The maximum number of positive correlations between indicators of lipid profile and inflammation markers was found in group 1, the minimum in group 3. This analysis showed the presence of chronic inflammation, which was accompanied by various disorders of lipid metabolism, even in the absence of clinical signs of pathology, the severity of which increased with increasing BMI and the development of metabolic syndrome.
RESUMO
When planning your diet regime is desirable to focus on the natural feeding behavior of the person. However, many aspects of eating behavior are not studied. The aim of this work was to study the changes of diet calorie and nutrient composition depending on the body mass index (BMI), time of day, week cycle phase: weekends/weekdays, and the availability of rational installation in nutrition. The study involved 67 women aged 29 to 49 years with a BMI of 18.3 to 34.2 kg/m2. Macronutrient composition and energy value of the diet were evaluated by analyzing the food diaries, which were filled by all respondents continuously for 8 workdays and 4 weekends. The results of this study showed no significant correlation between BMI and calorie intake, while a positive correlation was observed between BMI and fat component of the diet (r=0.362, p≤0.05). It was also found that the restriction of food intake in the evening (after 8 pm) did not lead to a decrease in total daily energy value of the diet, and was characterized by the consumption in the evening about 31% of the total fat intake. Diet energy value was significantly higher on weekends than during the week and was 2376±394 against 1940±402 kcal (p<0.05). According to the data obtained, compliance «restriction of supply in the evening¼ does not lead to a significant reduction in daily caloric intake.
