RESUMO
OBJECTIVES: The aim of our study was to investigate the relationship between neutrophil-to-lymphocyte ratio (NLR) and aortic elasticity in patients with newly diagnosed essential hypertension (HT). DESIGN: A total of 101 patients with newly diagnosed and untreated essential HT and 54 healthy control patients were enrolled. Aortic stiffness (ß) index, aortic strain and aortic distensibility (AoD) were measured with formulas by using transthoracic echocardiography and office blood pressure obtained by sphygmomanometer data. NLR was calculated using complete blood count. RESULTS: Patients with HT had significantly higher NLR compared with the healthy control group (2.49±0.77 vs. 1.80±0.65, P<0.001). In addition, there were significant differences between the HT and healthy control groups in ß index (12.7±7.35 vs. 6.97±3.3, P<0.001) and AoD (3.0±1.54 vs. 4.85±1.35, P<0.001). There was also a statistically significant correlation between NLR and ß index (r=0.727, P<0.001) and AoD (r=-0.606, P<0.001) parameters in hypertensive patients. CONCLUSION: Our results showed that in patients with newly diagnosed and untreated essential HT, increased NLR has been significantly linked to impaired aortic elastic properties.
Assuntos
Pressão Sanguínea , Hipertensão/sangue , Hipertensão/fisiopatologia , Rigidez Vascular , Adulto , Feminino , Humanos , Cooperação Linfocítica , Masculino , Pessoa de Meia-IdadeRESUMO
Eisenmenger syndrome is characterized by elevated pulmonary vascular resistance and right-to-left shunting of blood through a systemic to pulmonary circulation connection. Treatment requires either lung transplantation with intracardiac repair or heart-lung transplantation. There are inadequate data regarding treatment alternatives when the patient is not a candidate for surgery. In this article, we report on the case of a 68-year-old woman with Eisenmenger syndrome related to congenital heart disease who was treated with inhaled iloprost and oral sildenafil for 2 years.
