1.
J Org Chem
; 89(12): 8931-8936, 2024 Jun 21.
Artigo
em Inglês
| MEDLINE
| ID: mdl-38819196
RESUMO
A method of synthesizing hydroindole skeletons has been developed by using photocatalytic oxidative dearomatization and an aza-Michael addition sequence. Using this method, optically active hydroindoles, which are often used in natural product synthesis as chiral building blocks, can be easily prepared with >99% ee. Furthermore, the synthesis of melodamide A and (±)-toussaintine C was achieved using this method as a key step.