Conversion and pharmacokinetic studies of a microemulsion formulation of cyclosporine in pediatric liver transplant patients.

A study of conversion from the standard cyclosporine treatment to a microemulsion formulation was performed in 29 stable pediatric liver transplant patients. The study was divided into conversion and in follow-up phases. While on therapy with the standard formulation at a mean daily dose+/-SD of 231+/-101.8 mg patients had a mean cyclosporine trough level of 188.7+/-51.4 ng/ml. Following a 1:1 conversion from the standard to the microemulsion formulation an increase in the cyclosporine trough level was observed in 75% of the patients. The mean cyclosporine trough level at this point was 221.5+/-69.7 ng/ml. On follow-up, the dose had to be reduced an average of 21.7% in 49% of the patients, whereas the rest remained stable. The incidence of adverse events was not significant and no differences were observed between the two formulations. The pharmacokinetic study of the microemulsion in 11 patients showed a monophasic curve, with an early absorption at 30 min and maximum concentration+/-SD of 880.8+/-72.8 ng/ml and time to maximum concentration of 1.5+/-0.12 hr. Basal time showed the least correlation with the area under the curve and T4 the most statistically significant. The microemulsion showed better bioavailability and pharmacokinetic characteristics than the standard formulation.

Aerobic capacity of forestry workers and physical demands of forestry operations.

The present study aimed at evaluating the aerobic capacities of forestry workers and the physical demands of their occupation. A submaximal cycle ergometer test was conducted on 22 male forestry workers and 15 male sedentary office workers aged 40-59 years. The slope of the regression line of heart rates on given exercise intensities was significantly smaller in the forestry workers than in the office workers. The mean heart rate of the forestry workers was 9 beats.min-1 less than that of the office workers at the initial exercise intensity of 50 W. This difference increased to 25 beats.min-1 at 175 W. For 6 of the 22 forestry workers, heart rates were recorded continuously during a usual workday. The metabolic rates, as multiples of basal metabolic rate (in met) of various forestry activities were estimated from the average heart rate during the activity of interest and a predicted maximal oxygen consumption of the subject obtained from a submaximal cycle ergometer test. The mean energy expenditure was 4.5 met with a range of 3.3-6.3 met for an average of 509 min at a worksite. These results indicated that the forestry workers had high aerobic capacities and this was ascribed to the high physical demands of their occupation.