Preparing a task is sufficient to generate a subsequent task-switch cost affecting task performance.

This study investigated the nature of switch costs after trials on which the cued task had been either only prepared (cue-only trials) or both prepared and performed (completed trials). Previous studies have found that task-switch costs occur following cue-only trials, demonstrating that preparing-without performing-a task is sufficient to produce a subsequent switch cost. However, it is not clear whether switch costs after these different types of trial reflect an impact of task-switching upon task preparation or task performance on the current trial. The present study examined this question using a double-registration procedure with both cue-only and completed trials. Participants responded to both task-cue and target stimuli. In cue responses, a cost of switching task cues (cue-switch cost) but not of switching tasks (task-switch cost) followed both cue-only and completed trials. In target responses, a task-switch cost but no cue-switch cost followed both cue-only trials and completed trials, and this task-switch cost was larger following completed than cue-only trials. The presence of the task-switch cost in target responses following cue-only trials indicates a specific impact of previous preparation upon task performance, and the increased size of this cost following completed trials indicates an additional impact of previous performance. Together, these results suggest that both task preparation and task performance contribute to the subsequent task-switch cost affecting task performance. (PsycInfo Database Record (c) 2024 APA, all rights reserved).

Differences in Approach and Avoidance Motivation Sensitivities Predicting Participation and Performance in Strength Sport.

ABSTRACT: Cusimano, K, Freeman, P, Moran, J, and Yamaguchi, M. Differences in approach and avoidance motivation sensitivities predicting participation and performance in strength sport. J Strength Cond Res 38(1): 180-184, 2024-Gray's Reinforcement Sensitivity Theory proposes that individual differences in behavior are due to the sensitivity to 2 brain systems: the behavioral inhibition system (BIS), which regulates aversive emotions to threatening stimuli, and the behavioral approach system (BAS), which regulates positive emotions toward rewarding or nonpunishing stimuli. The current study investigated whether BIS and BAS sensitivity predicts participation and performance in strength sports. A sample of 177 competitive strength athletes (male = 148; female = 29; mean age = 28.68; SD = 6.24 years) and 178 control participants (male = 89; female = 89; mean age = 29.39; SD = 7.42) completed the BIS/BAS scale, with strength athletes also providing their Wilks scores as a measure of sporting performance. Independent t tests showed significantly higher BIS (MD = 2.37, p = 0.003, 95% CI [0.79, 3.94], d = 0.31) and total BAS (MD = 11.71, p < 0.001, 95% CI [9.26, 14.15], d = 1.00) sensitivity in strength athletes than individuals in the control group. A 3-step hierarchical regression analysis revealed that the number of training years (ß = 0.506, p < 0 .001), BIS (ß = -203, p = 0.005) and BAS drive (ß = 0.188, p = 0.012) made significant unique contributions to predicting the Wilks score, with no significant contributions of age, sex, BAS fun seeking, and BAS reward responsiveness. The findings indicate that the overall reward sensitivity (total BAS score) and reward seeking (BAS drive) are associated positively with participation and performance in strength sports, respectively. Given the association of these brain systems to addiction and other psychiatric disorders, the findings could have implications in psychiatric treatment and sporting recruitment.

Investigating task preparation and task performance as triggers of the backward inhibition effect.

Backward inhibition is posited to aid task switching by counteracting the tendency to repeat a recent task. Evidence that factors such as cue transparency affect backward inhibition seems to imply that it is generated during task preparation, making its absence following trials on which a prepared task was not performed (nogo trials) surprising. However, the nogo method used in previous studies might have prevented detection of preparation-driven effects. We used a truncated-trial method instead, omitting stages of a trial with no need for a nogo signal. In Experiment 1, an n - 2 repetition cost (suggested to indicate backward inhibition) followed trials truncated after response selection, indicating that response execution is not necessary to trigger backward inhibition. In Experiments 2 and 3, no n - 2 repetition cost was obtained following trials truncated after cue presentation. To ensure some task preparation on cue-only trials, Experiment 4 used a double-registration procedure where participants responded to the task cue and the target on each trial. In contrast to Experiments 2 and 3, a small n - 2 repetition cost followed trials truncated after cue responses, affecting cue responses on the current trial. In addition, the n - 2 repetition cost was increased at cue responses and became evident at target responses when the preceding trial also involved a target response. These results imply that backward inhibition might be generated by processes occurring up to and including a cue response, affecting subsequent cue responses, as well as during task performance itself, affecting subsequent cue and target responses.

Orally administrable peptides derived from egg yolk promote skeletal repair and ameliorate degenerative skeletal disorders in mouse models.

Introduction: Aging, genetic mutations, and other pathological conditions cause impairment of skeletal growth and bone metabolism, which affect activities of daily living and quality of life in all life stages. Although several drugs have been used in clinical settings and new drugs have been developed for the treatment of skeletal degenerative disorders such as osteoporosis and genetic disorders such as osteogenesis imperfecta (OI), there is clear demand for development of new drugs, especially orally available anabolic drugs that are applicable for a wide range of skeletal disorders. Methods: To identify therapeutic candidates for skeletal disorders, peptide screening was performed. To validate the identified peptides, we performed a bone histomorphometric analysis with rat bone tissues and in vitro cell proliferation assays of skeletal cells. To understand the metabolism of the peptides, we performed a biochemical analysis, followed by in vitro assays for proliferation and differentiation of skeletal cells. We examined the therapeutic efficacy of the identified peptides with several mouse models representing skeletal disorders including bone fracture, osteoporosis, and osteogenesis imperfecta. In vivo therapeutic effects of the candidate were assessed with radiological analysis and mechanical property tests. Results: We identified the egg yolk-derived functional peptide PF201. PF201 promoted in vivo bone formation in rodents and enhanced proliferation of osteoblasts and chondrocytes in vitro. D2, a metabolite of PF201, was present and circulated after digestion and absorption in the digestive tract. D2 had positive impacts on the proliferation and differentiation of mesenchymal stem cells and preosteoblasts. Oral administration of D2 accelerated bone healing in a mouse fracture model. D2 also improved bone strength and fracture healing under ovariectomy-induced osteoporotic conditions in mice, and D2 showed a therapeutic effect in a mouse OI model. Conclusion: D2 is likely to be a candidate for an orally available therapeutic for a range of skeletal disorders.

Effectiveness of Lateral Auditory Collision Warnings: Should Warnings Be Toward Danger or Toward Safety?

OBJECTIVE: The present study investigated the design of spatially oriented auditory collision-warning signals to facilitate drivers' responses to potential collisions. BACKGROUND: Prior studies on collision warnings have mostly focused on manual driving. It is necessary to examine the design of collision warnings for safe takeover actions in semi-autonomous driving. METHOD: In a video-based semi-autonomous driving scenario, participants responded to pedestrians walking across the road, with a warning tone presented in either the avoidance direction or the collision direction. The time interval between the warning tone and the potential collision was also manipulated. In Experiment 1, pedestrians always started walking from one side of the road to the other side. In Experiment 2, pedestrians appeared in the middle of the road and walked toward either side of the road. RESULTS: In Experiment 1, drivers reacted to the pedestrian faster with collision-direction warnings than with avoidance-direction warnings. In Experiment 2, the difference between the two warning directions became nonsignificant. In both experiments, shorter time intervals to potential collisions resulted in faster reactions but did not influence the effect of warning direction. CONCLUSION: The collision-direction warnings were advantageous over the avoidance-direction warnings only when they occurred at the same lateral location as the pedestrian, indicating that this advantage was due to the capture of attention by the auditory warning signals. APPLICATION: The present results indicate that drivers would benefit most when warnings occur at the side of potential collision objects rather than the direction of a desirable action during semi-autonomous driving.

When two actors perform different tasks: Still no evidence for shared task-sets in joint task switching.

Two different variations of joint task switching led to different conclusions as to whether co-acting individuals share the same task-sets. The present study aimed at bridging this gap by replicating the version in which two actors performed two different tasks. Experiment 1 showed switch costs across two actors in a joint condition, which agreed with previous studies, but also yielded even larger switch costs in a solo condition, which contradicted the claim that actors represent an alternative task as their own when it is carried out by the co-actor but not when no one carries it out. Experiments 2 and 3 further examined switch costs in the solo condition with the aim to rule out possible influences of task instructions for and experiences with the other task that was not assigned to the actor. Before participants were instructed on the second of the two tasks, switch costs were still obtained without a co-actor when explicit task names ("COLOUR" and "SHAPE") served as go/nogo signals (Experiment 2), but not when arbitrary symbols ("XXXX" and "++++") served as go/nogo signals (Experiment 3). The results thus imply that switch costs depend on participants' knowledge of task cues being assigned to two different tasks, but not on whether the other task is performed by a co-actor. These findings undermine the assumption that switch costs in the joint conditions reflect shared task-sets between co-actors in this procedure.

Epitope-Based Chicken-Derived Novel Anti-PAD2 Monoclonal Antibodies Inhibit Citrullination.

The aberrant upregulation of protein arginine deiminase 2- (PAD2-) catalyzed citrullination is reported in various autoimmune diseases (rheumatoid arthritis and multiple sclerosis) and several cancers. Currently, there are no anti-PAD2 monoclonal antibodies (mAbs) that can inhibit the citrullination reaction. Here, an epitope 341YLNRGDRWIQDEIEFGY357 was examined as an antigenic site of PAD2. Chickens were immunized with this epitope, and the generated mAbs were screened for its reactivity against the full-length PAD2. Enzyme-linked immunosorbent assay revealed that six mAbs, which were screened from the phage display library, crossreacted with mouse PAD2. Kinetic analysis revealed that mAbs are bound to PAD2 in the nanomolar range, which indicated a strong binding. Results of the in vitro citrullination inhibition assay revealed that the half-maximal effective concentration values of mAbs for the inhibition of histone or benzoyl-L-arginine ethyl ester citrullination were in the range of 6-75 nM which supports strong inhibition capabilities. Alanine scanning of epitope revealed that the peptide fragment 344RGDRWIQDEIEF355 was responsible for generating strong antibody responses that inhibit the PAD2-catalyzed citrullination reaction. These antibodies can aid in understanding the extracellular PAD2 function and treating diseases associated with aberrant citrullination.

The role of explicit categorization in the Implicit Association Test.

The present study investigated how task-irrelevant attributes of a stimulus affected responses in a multiattribute version of the Implicit Association Test (IAT). In Experiment 1, participants categorized images of Black and White male and female individuals on the basis of either race or gender. Both the race and gender of the individuals affected task performance regardless of which attribute was currently relevant to performing the task, yielding the IAT effects on both attributes. However, the influences of a task-irrelevant attribute depended on whether the task-relevant attribute was categorized compatibly or incompatibly with the underlying implicit biases. These results suggest that individuals are still categorized implicitly based on task-irrelevant social attributes and that the explicit categorization required in the standard IAT has a considerable impact on implicit social biases. Experiment 2 considered a third, nonsocial attribute (the color of the picture frame) and reproduced task-irrelevant IAT effects and their dependence on explicit categorization. However, Experiments 3 and 4 suggested that the task-irrelevant IAT effects based on social attributes are determined by whether the task-relevant attribute is a social or nonsocial attribute. The results raise fundamental questions about the basic assumptions underpinning the interpretations of the results from the IAT. (PsycInfo Database Record (c) 2020 APA, all rights reserved).

Modulating proactive cognitive control by reward: differential anticipatory effects of performance-contingent and non-contingent rewards.

The present study investigated the influences of two different forms of reward presentation in modulating cognitive control. In three experiments, participants performed a flanker task for which one-third of trials were precued for a chance of obtaining a reward (reward trials). In Experiment 1, a reward was provided if participants made the correct response on reward trials, but a penalty was given if they made an incorrect response on these trials. The anticipation of this performance-contingent reward increased response speed and reduced the flanker effect, but had little influence on the sequential modulation of the flanker effect after incompatible trials. In Experiment 2, participants obtained a reward randomly on two-thirds of the precued reward trials and were given a penalty on the remaining one-third, regardless of their performance. The anticipation of this non-contingent reward had little influence on the overall response speed or flanker effect, but reduced the sequential modulation of the flanker effect after incompatible trials. Experiment 3 also used performance non-contingent rewards, but participants were randomly penalized more often than they were rewarded; non-contingent penalty had little influence on the sequential modulation of the flanker effect. None of the three experiments showed a reliable influence of the actual acquisition of rewards on task performance. These results indicate anticipatory effects of performance-contingent and non-contingent rewards on cognitive control with little evidence of aftereffects.

The roles of action selection and actor selection in joint task settings.

Studies on joint task performance have proposed that co-acting individuals co-represent the shared task context, which implies that actors integrate their co-actor's task components into their own task representation as if they were all their own task. This proposal has been supported by results of joint tasks in which each actor is assigned a single response where selecting a response is equivalent to selecting an actor. The present study used joint task switching, which has previously shown switch costs on trials following the actor's own trial (intrapersonal switch costs) but not on trials that followed the co-actor's trial (interpersonal switch costs), suggesting that there is no task co-representation. We examined whether interpersonal switch costs can be obtained when action selection and actor selection are confounded as in previous joint task studies. The present results confirmed this prediction, demonstrating that switch costs can occur within a single actor as well as between co-actors when there is only a single response per actor, but not when there are two responses per actor. These results indicate that task co-representation is not necessarily implied even when effects occur across co-acting individuals and that how the task is divided between co-actors plays an important role in determining whether effects occur between co-actors.

Affective influences without approach-avoidance actions: on the congruence between valence and stimulus-response mappings.

The valence of stimuli can influence performance in the spatial stimulus-response compatibility task, but this observation could arise from the process of selecting responses or selecting stimulus-response mappings. The response-selection account proposes that spatial compatible and incompatible keypress responses serve as approaching and avoiding actions to a valenced target. The mapping-selection account suggests that there is congruence between stimulus valence and stimulus-response mappings; positive-compatible/negative-incompatible is more congruent than negative-compatible/positive-incompatible. Whereas affective valence was part of the target stimuli to which participants responded in previous studies, the present study isolated affective valence from the target by presenting an additional mapping cue separately from the target, so that spatially compatible and incompatible keypress responses could no longer serve as approaching and avoiding actions to valenced target stimuli. The present results revealed that responses were still faster when positive and negative mapping cues were assigned to the spatially compatible and incompatible mappings than when the assignment was reversed. The finding supports the mapping-selection account, indicating that positive and negative cues influence performance without approach-avoidance actions to valenced stimuli. The experiment provides important implications as to how tasks are represented and are dependent on affective processing.

Is Your Color My Color? Dividing the Labor of the Stroop Task Between Co-actors.

Performing a task with other actors involves two opposing forces, division of labor between co-acting individuals and integration of divided parts of the task into a shared mental representation (co-representation). Previous studies have focused primarily on the integration of task representations and limited attention has paid to the division of labor. The present study devised a test of the integration and the division in a joint task setting. A joint version of the Stroop task was developed, in which pairs of actors were assigned different sets of target colors. If the actors integrate their co-actor's task, the colors assigned to their co-actor should be represented as if they were the actor's own target colors; the Stroop effect should be as large when distractor color words denote their co-actor's target colors as when these words denote the actor's own target colors. If the actors divide the labor of the Stroop task, the colors assigned to their partner should be represented as non-target colors; the Stroop effect should be smaller when the distractor color words denote the co-actor's target colors than when these words denote the actor's own target colors. The results of response time did not provide clear support for either position, while those of response accuracy supported the division of labor. Possible cognitive mechanisms that support the division of labor and the integration of task representation are discussed.

Top-down contributions to attention shifting and disengagement: A template model of visual attention.

Two separate systems are involved in the control of spatial attention; one that is driven by a goal, and the other that is driven by stimuli. While the goal- and stimulus-driven systems follow different general principles, they also interplay with each other. However, the mechanism by which the goal-driven system influences the stimulus-driven system is still debated. The present study examined top-down contributions to two components of attention orienting, shifting and disengagement, with an experimental paradigm in which participants held a visual item in short-term memory (STM) and performed a prosaccade task with a manipulation of the gap between fixation offset and target onset. Four experiments showed that the STM content accelerated shifting and impaired disengagement, but the influence on disengagement depended on the utility of STM in guiding attention toward the target. Thus, the use of STM was strategic. Computational models of visual attention were fitted to the experimental data, which suggested that the top-down contributions to shifting was more prominent than those to disengagement. The results indicate that the current modeling framework was particularly useful when examining the contributions of theoretical constructs for the control of visual attention, but it also suggests limitations. (PsycINFO Database Record

Sharing tasks or sharing actions? Evidence from the joint Simon task.

In a joint Simon task, a pair of co-acting individuals divide labors of performing a choice-reaction task in such a way that each actor responds to one type of stimuli and ignores the other type that is assigned to the co-actor. It has been suggested that the actors share the mental representation of the joint task and perform the co-actor's trials as if they were their own. However, it remains unclear exactly which aspects of co-actor's task-set the actors share in the joint Simon task. The present study addressed this issue by manipulating the proportions of compatible and incompatible trials for one actor (inducer actor) and observing its influences on the performance of the other actor (diagnostic actor) for whom there were always an equal proportion of compatible and incompatible trials. The design of the present study disentangled the effect of trial proportion from the confounding effect of compatibility on the preceding trial. The results showed that the trial proportions for the inducer actor had strong influences on the inducer actor's own performance, but it had little influence on the diagnostic actor's performance. Thus, the diagnostic actor did not represent aspects of the inducer actor's task-set beyond stimuli and responses of the inducer actor. We propose a new account of the effect of preceding compatibility on the joint Simon effect.

Dissecting Deep Learning Networks-Visualizing Mutual Information.

Deep Learning (DL) networks are recent revolutionary developments in artificial intelligence research. Typical networks are stacked by groups of layers that are further composed of many convolutional kernels or neurons. In network design, many hyper-parameters need to be defined heuristically before training in order to achieve high cross-validation accuracies. However, accuracy evaluation from the output layer alone is not sufficient to specify the roles of the hidden units in associated networks. This results in a significant knowledge gap between DL's wider applications and its limited theoretical understanding. To narrow the knowledge gap, our study explores visualization techniques to illustrate the mutual information (MI) in DL networks. The MI is a theoretical measurement, reflecting the relationship between two sets of random variables even if their relationship is highly non-linear and hidden in high-dimensional data. Our study aims to understand the roles of DL units in classification performance of the networks. Via a series of experiments using several popular DL networks, it shows that the visualization of MI and its change patterns between the input/output with the hidden layers and basic units can facilitate a better understanding of these DL units' roles. Our investigation on network convergence suggests a more objective manner to potentially evaluate DL networks. Furthermore, the visualization provides a useful tool to gain insights into the network performance, and thus to potentially facilitate the design of better network architectures by identifying redundancy and less-effective network units.

Flowers and spiders in spatial stimulus-response compatibility: does affective valence influence selection of task-sets or selection of responses?

The present study examined the effect of stimulus valence on two levels of selection in the cognitive system, selection of a task-set and selection of a response. In the first experiment, participants performed a spatial compatibility task (pressing left and right keys according to the locations of stimuli) in which stimulus-response mappings were determined by stimulus valence. There was a standard spatial stimulus-response compatibility (SRC) effect for positive stimuli (flowers) and a reversed SRC effect for negative stimuli (spiders), but the same data could be interpreted as showing faster responses when positive and negative stimuli were assigned to compatible and incompatible mappings, respectively, than when the assignment was opposite. Experiment 2 disentangled these interpretations, showing that valence did not influence a spatial SRC effect (Simon effect) when task-set retrieval was unnecessary. Experiments 3 and 4 replaced keypress responses with joystick deflections that afforded approach/avoidance action coding. Stimulus valence modulated the Simon effect (but did not reverse it) when the valence was task-relevant (Experiment 3) as well as when it was task-irrelevant (Experiment 4). Therefore, stimulus valence influences task-set selection and response selection, but the influence on the latter is limited to conditions where responses afford approach/avoidance action coding.

Action-effect sharing induces task-set sharing in joint task switching.

A central issue in the study of joint task performance has been one of whether co-acting individuals perform their partner's part of the task as if it were their own. The present study addressed this issue by using joint task switching. A pair of actors shared two tasks that were presented in a random order, whereby the relevant task and actor were cued on each trial. Responses produced action effects that were either shared or separate between co-actors. When co-actors produced separate action effects, switch costs were obtained within the same actor (i.e., when the same actor performed consecutive trials) but not between co-actors (when different actors performed consecutive trials), implying that actors did not perform their co-actor's part. When the same action effects were shared between co-actors, however, switch costs were also obtained between co-actors, implying that actors did perform their co-actor's part. The results indicated that shared action effects induce task-set sharing between co-acting individuals.

Pushing typists back on the learning curve: Memory chunking improves retrieval of prior typing episodes.

Hierarchical control of skilled performance depends on chunking of several lower-level units into a single higher-level unit. The present study examined the relationship between chunking and recognition of trained materials in the context of typewriting. In 3 experiments, participants were trained with typing nonwords and were later tested on their recognition of the trained materials. In Experiment 1, participants typed the same words or nonwords in 5 consecutive trials while performing a concurrent memory task. In Experiment 2, participants typed the materials with lags between repetitions without a concurrent memory task. In both experiments, recognition of typing materials was associated with better chunking of the materials. Experiment 3 used the remember-know procedure to test the recollection and familiarity components of recognition. Remember judgments were associated with better chunking than know judgments or nonrecognition. These results indicate that chunking is associated with explicit recollection of prior typing episodes. The relevance of the existing memory models to chunking in typewriting was considered, and it is proposed that memory chunking improves retrieval of trained typing materials by integrating contextual cues into the memory traces. (PsycINFO Database Record