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1.
Allergol Int ; 58(4): 509-18, 2009 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-19700936

RESUMO

BACKGROUND: Whether the additive effects of the tulobuterol patch (TP), the world's first transdermal beta2-agonist preparation, are useful in asthma patients receiving inhaled corticosteroid (ICS) is unclear. To examine the add-on effects of TP on bronchial hyperresponsiveness and reduction of the percentage of sputum eosinophils, and to compare add-on effects of TP, slow-release theophylline (SRT), and a leukotriene receptor antagonist (LTRA) in patients with asthma receiving ICS. METHODS: Study 1: We randomly allocated 24 patients with asthma receiving ICS alone in equal numbers to either control treatment (ICS alone at conventional doses) or TP treatment (ICS at conventional doses plus TP at 2mg/day). Following a 2-week observation period, patients received the allocated drug regimens for 4 weeks. Methacholine challenge test and measurement of percentage of eosinophils in hypertonic saline-induced sputum were performed before and after the treatment period. Study 2: We compared add-on effects of TP, SRT, and LTRA in 65 patients with asthma receiving ICS alone, using spirometry and peak expiratory flow (PEF). Participants in these studies had experienced decrease in morning PEF to <80% of the predicted value at least twice a week. RESULTS: Study 1: In the TP group, improvement of bronchial hyperresponsiveness and decrease in percentage of sputum eosinophils both indicated a statistically significant difference (p < 0.01, and p < 0.05, respectively). These findings were not observed in the control group. Study 2: forced expiratory volume in 1 second (FEV(1)) and PEF markedly increased after treatment with TP compared with treatment with SRT or LTRA. CONCLUSIONS: These findings suggest that TP can be used as a long-term add-on controller for patients with asthma receiving ICS.


Assuntos
Corticosteroides/uso terapêutico , Agonistas Adrenérgicos beta/uso terapêutico , Asma/tratamento farmacológico , Terbutalina/análogos & derivados , Administração por Inalação , Adulto , Idoso , Asma/patologia , Asma/fisiopatologia , Contagem de Células , Sistemas de Liberação de Medicamentos , Quimioterapia Combinada , Eosinófilos/citologia , Feminino , Humanos , Antagonistas de Leucotrienos/uso terapêutico , Masculino , Pessoa de Meia-Idade , Testes de Função Respiratória , Escarro/citologia , Terbutalina/uso terapêutico , Teofilina/uso terapêutico , Resultado do Tratamento
2.
Nihon Kokyuki Gakkai Zasshi ; 45(2): 153-9, 2007 Feb.
Artigo em Japonês | MEDLINE | ID: mdl-17352172

RESUMO

The prognosis of malignant pleural mesothelioma is poor, but selected patients might benefit from multimodality treatment. To establish the means that are available to predict the variable course of the disease in malignant pleural mesothelioma patients, we retrospectively investigated the correlation of clinico-pathological features of 54 patients with survival. Twenty-three patients received treatment, while 31 were referred to supportive care only. The median survival of the entire group was 8.6 months. The 1-year survival was 33.2%. Univariate analysis of subgroups showed that age over 70 years, non-epithelial histologic type, patients treated with supportive care only, and delayed diagnosis were individually associated with lower survival. The European Organization for Research and Treatment of Cancer (EORTC) score showed a significant correlation with survival (P = 0.0146). The median survival of patients with an EORTC score of over 1.27 was 3.5 months, compared to 10.5 months for patients with an EORTC score of 1.27 or less. Tumor necrosis (TN) was a poor prognostic factor on univariate analysis (P = 0.0077). Patients with TN had a median survival of 7.0 months vs 15.5 months in negative cases. On multivariate analysis, TN was determined as an independent prognostic factor (P = 0.0349). EORTC prognostic scoring systems successfully stratify survival for a general hospital population, and TN might play an important role in poor outcome in malignant pleural mesothelioma.


Assuntos
Mesotelioma/patologia , Neoplasias Pleurais/patologia , Adulto , Idoso , Idoso de 80 Anos ou mais , Feminino , Humanos , Masculino , Mesotelioma/mortalidade , Pessoa de Meia-Idade , Necrose/mortalidade , Necrose/patologia , Neoplasias Pleurais/mortalidade , Prognóstico , Estudos Retrospectivos , Taxa de Sobrevida
3.
Intern Med ; 45(12): 763-7, 2006.
Artigo em Inglês | MEDLINE | ID: mdl-16847365

RESUMO

We report a case of spontaneous coronary artery dissection (SCAD) causing acute myocardial infarction, which was complicated by vasospastic angina (VA). The patient received intravenous administration of t-PA. Emergency coronary angiography demonstrated narrowing of the left anterior descending artery (LAD) due to SCAD. During hospitalization, the patient suffered chest pain, and ECG showed ST elevation in the inferior leads. Sublingual administration of nitroglycerin provided temporary remission. Coronary stent implantation was performed electively using intravascular ultrasound imaging. This is the first reported case of SCAD associated with vasospasm in a non-culprit coronary artery during the hospitalization.


Assuntos
Dissecção Aórtica/complicações , Aneurisma Coronário/complicações , Vasoespasmo Coronário/complicações , Infarto do Miocárdio/etiologia , Adulto , Dissecção Aórtica/diagnóstico , Dissecção Aórtica/cirurgia , Angina Pectoris/etiologia , Aneurisma Coronário/diagnóstico , Aneurisma Coronário/cirurgia , Angiografia Coronária , Endossonografia , Feminino , Humanos , Infarto do Miocárdio/tratamento farmacológico , Stents , Ativador de Plasminogênio Tecidual/farmacologia , Ultrassonografia de Intervenção
4.
Intern Med ; 45(3): 151-4, 2006.
Artigo em Inglês | MEDLINE | ID: mdl-16508229

RESUMO

Accidental or deliberate ingestion of bromate solution has been reported in pediatric as well as adult cases; however there have been no reports of such intoxication in the elderly. We report a 78-year-old woman who suffered severe acute renal failure due to the accidental ingestion of sodium bromate solution. The patient was successfully treated with hemodialysis therapy and renal function recovered without hearing loss. This case suggests that emergency therapeutic measures, including hemodialysis, should be taken as soon as possible, and the rapid removal of bromate is essential to prevent severe intoxication and its sequelae. To the best of our knowledge this is the first report of an elderly patient that demonstrates the clinical benefit of hemodialysis therapy for bromate intoxication.


Assuntos
Injúria Renal Aguda/induzido quimicamente , Bromatos/intoxicação , Compostos de Sódio/intoxicação , Injúria Renal Aguda/patologia , Injúria Renal Aguda/terapia , Idoso , Feminino , Humanos , Rim/patologia , Diálise Renal
8.
Am J Cardiol ; 96(1): 89-91, 2005 Jul 01.
Artigo em Inglês | MEDLINE | ID: mdl-15979441

RESUMO

Thirty-two patients were randomly assigned to treatment with placebo or atorvastatin. The time-averaged peak diastolic velocity (APDV) of the left anterior descending artery without stenosis was measured by transthoracic Doppler echocardiography at rest and under hyperemic conditions before and 1 hour after treatment. APDV increased significantly in the atorvastatin group, at rest and under hyperemic conditions, and coronary flow velocity reserve also increased in the atorvastatin group compared with patients given placebo. Atorvastatin improved the blood flow velocity of the normal coronary artery <1 hour after administration in patients without coronary artery disease by angiography.


Assuntos
Anticolesterolemiantes/farmacologia , Circulação Coronária/efeitos dos fármacos , Ácidos Heptanoicos/farmacologia , Pirróis/farmacologia , Idoso , Anticolesterolemiantes/administração & dosagem , Anticolesterolemiantes/uso terapêutico , Atorvastatina , Angiografia Coronária , Ecocardiografia Doppler , Feminino , Ácidos Heptanoicos/administração & dosagem , Ácidos Heptanoicos/uso terapêutico , Humanos , Masculino , Pessoa de Meia-Idade , Placebos , Pirróis/administração & dosagem , Pirróis/uso terapêutico , Fluxo Sanguíneo Regional
9.
Intern Med ; 44(3): 243-5, 2005 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-15805715

RESUMO

Paradoxical embolism may occur in patients with acute pulmonary thromboembolism, when patent foramen ovale (PFO) coexists with pulmonary hypertension (right-left shunt). There have been few case reports of paradoxical embolism in peripheral arteries coincident with acute pulmonary thromboembolism. Here, we describe a case of paradoxical peripheral embolism associated with PFO complicated by acute pulmonary thromboembolism. The patient had severe peripheral ischemia due to a massive thrombus and was treated successfully by peripheral thrombectomy, thrombolysis, implantation of a permanent inferior vena cava filter and anticoagulation.


Assuntos
Embolia Paradoxal/etiologia , Comunicação Interatrial/complicações , Embolia Pulmonar/etiologia , Doença Aguda , Idoso , Implante de Prótese Vascular/instrumentação , Embolia Paradoxal/terapia , Feminino , Seguimentos , Humanos , Embolia Pulmonar/terapia , Trombectomia , Terapia Trombolítica , Filtros de Veia Cava
11.
Intern Med ; 42(9): 824-6, 2003 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-14518669

RESUMO

We describe the use of short-term epoprostenol in a 61-year-old man with primary pulmonary hypertension. The patient was on a ventilator because of respiratory distress. Continuous infusion of epoprostenol was started and it initially reduced the pulmonary artery pressure by 32%. Epoprostenol was tapered, and even after discontinuation, the pulmonary artery pressure was controlled. The ventilator was removed, and the patient remained well on home oxygen therapy 3 months after discharge.


Assuntos
Anti-Hipertensivos/administração & dosagem , Epoprostenol/administração & dosagem , Hipertensão Pulmonar/tratamento farmacológico , Insuficiência Respiratória/terapia , Humanos , Hipertensão Pulmonar/complicações , Infusões Parenterais , Masculino , Pessoa de Meia-Idade , Respiração Artificial/métodos , Insuficiência Respiratória/etiologia , Resultado do Tratamento , Desmame do Respirador
12.
Intern Med ; 41(11): 990-2, 2002 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-12487175

RESUMO

A case of a 29-year-old woman with intralobar pulmonary sequestration infected with Mycobacterium intracellulare is presented. A chest CT scan revealed a density in the posterior segment of the left lower lobe, and an acid-fast bacillus sputum culture yielded Mycobacterium intracellulare. After 3 months of treatment with clarithromycin, streptomycin, rifampicin and ethambutol, the patient underwent partial resection of the left lower lobe. At the 6-month follow-up the patient's clinical status is excellent. A review of the literature revealed only three case reports of pulmonary sequestration associated with Mycobacterium avium-intracellulare complex infection.


Assuntos
Sequestro Broncopulmonar/complicações , Infecção por Mycobacterium avium-intracellulare/complicações , Adulto , Feminino , Humanos
13.
Diabetes Res Clin Pract ; 57(1): 61-9, 2002 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-12007731

RESUMO

The present study addressed whether diabetes mellitus was a strong risk factor for cardiovascular disease (CVD) death. Between 1976 and 1984, 927 (404 men) Japanese-Americans in Hawaii aged 40-79 years participated at baseline examination including a 75 g oral glucose tolerance test. Diabetes was defined as fasting serum glucose >or=140 mg/dl, 2 h postload glucose >or=180 mg/dl, or the use of drugs for diabetes. Causes of death were classified by ICD-9 codes on the reports from the Hawaii State Public Health Bureau. Until 1994, 178 individuals suffered death; 81 were attributed to CVD and 43 to coronary heart disease (CHD). The age-adjusted and coronary risk factors-adjusted relative risks for CHD and CVD mortality were significant for diabetes both in men and women. The impact of diabetes on CHD mortality was greater for women. However, no gender difference in the contribution of diabetes to fatal CVD was observed. Serum fasting glucose levels tended to be associated with CHD death and were associated with CVD death in diabetic subjects. In conclusion, diabetes is a strong independent risk factor for CVD mortality in Japanese-American men and women. Hyperglycemia is associated with CVD mortality in diabetic subjects.


Assuntos
Doenças Cardiovasculares/mortalidade , Diabetes Mellitus Tipo 2/fisiopatologia , Angiopatias Diabéticas/mortalidade , Adulto , Idoso , Glicemia/metabolismo , Índice de Massa Corporal , Causas de Morte , Colesterol/sangue , Diabetes Mellitus Tipo 2/sangue , Feminino , Teste de Tolerância a Glucose , Havaí/epidemiologia , Humanos , Insulina/sangue , Japão/epidemiologia , Los Angeles/epidemiologia , Masculino , Pessoa de Meia-Idade , Fatores de Risco , Fumar , Triglicerídeos/sangue
15.
Chest ; 121(2): 652-4, 2002 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-11834686

RESUMO

We report two cases of septic pulmonary embolism associated with periodontitis. Chest CT revealed multiple nodular shadows with features characteristic of septic pulmonary embolism in both patients. Both patients had toothache, fever, and chest pain, and showed findings of periodontitis at initial presentation. Antimicrobial agents combined with dental surgery were successful in treatment. While septic pulmonary embolism from the lesions of periodontitis appears to be rare, periodontitis remains important in the differential diagnosis of septic pulmonary embolism.


Assuntos
Infecção Focal Dentária , Periodontite/complicações , Embolia Pulmonar/etiologia , Idoso , Humanos , Masculino , Pessoa de Meia-Idade
16.
J Allergy Clin Immunol ; 109(2): 294-8, 2002 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-11842300

RESUMO

BACKGROUND: Allergen-stimulated IL-5 production by CD4+ T cells is the key issue in atopic asthma. On the other hand, virus-specific CD8+ T cells produce IL-5 and might play an important role in the pathogenesis of nonatopic asthma. OBJECTIVES: We sought to compare the IL-5-producing T-lymphocyte subsets in the peripheral blood of atopic and nonatopic asthmatic subjects, especially the contribution of IL-5-producing CD8(+) T cells in nonatopic asthma. METHODS: Heparinized blood samples were obtained from subjects with atopic asthma (n = 10), subjects with nonatopic asthma (n = 10), and healthy subjects (n = 10) and stimulated with ionomycin and phorbol myristate acetate in the presence of brefeldin A. Two-color flow cytometric analysis with mAbs to cell-surface antigens and intracellular IL-5 was used to detect the IL-5-producing T-cell subsets. RESULTS: A higher percentage of IL-5-producing CD3(+) T cells was detected in subjects with atopic and nonatopic asthma than that seen in the healthy subjects. The percentage of IL-5-producing CD4(+) T cells was significantly higher in subjects with atopic asthma than in the healthy subjects. The percentage of IL-5-producing CD8(+) T cells was significantly higher in subjects with nonatopic asthma than in the healthy subjects. The percentage of IL-5-producing CD8(+) T cells was higher in subjects with nonatopic asthma than in those with atopic asthma, but the difference was not statistically significant. CONCLUSIONS: CD4(+) T cells are the major source of IL-5 among CD3(+) lymphocytes in subjects with atopic asthma. On the other hand, increased IL-5 production by CD8(+) T cells, as well as by CD4(+) T cells, is a characteristic feature of nonatopic asthma.


Assuntos
Asma/imunologia , Hipersensibilidade Imediata/imunologia , Interleucina-5/biossíntese , Subpopulações de Linfócitos T/imunologia , Adulto , Idoso , Complexo CD3/análise , Linfócitos T CD4-Positivos/imunologia , Linfócitos T CD8-Positivos/imunologia , Feminino , Citometria de Fluxo , Humanos , Masculino , Pessoa de Meia-Idade , Subpopulações de Linfócitos T/metabolismo
17.
J Am Soc Nephrol ; 11(11): 1969-1979, 2000 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-11053471

RESUMO

During continuous ambulatory peritoneal dialysis, the peritoneum is directly and continuously exposed to unphysiologic peritoneal dialysis fluid; the resulting mesothelial damage has been suggested to cause loss of ultrafiltration and dialysis efficacy. The present study investigated the effect of a high glucose concentration on cultured human peritoneal mesothelial cells to clarify the cause of decreased dialysis efficacy during prolonged peritoneal dialysis. High glucose caused a concentration-dependent decrease in cell proliferation, damage to the intercellular junctions, and excess production of transforming growth factor-beta (TGF-beta). The levels of intercellular junctional proteins (ZO-1, E-cadherin, and beta-catenin) were decreased, and immuno-staining by anti-ZO-1 and anti- beta-catenin antibodies became weaker and often discontinuous along the cell contour. Mannitol had similar but weaker effects at the same osmolality, and an anti-TGF-beta neutralizing antibody reduced the effects of high glucose. Therefore, these effects were induced not only by glucose itself but also by hyperosmolality and by a glucose-induced increase of TGF-beta. These findings suggest that the peritoneal mesothelium is damaged by prolonged peritoneal dialysis using high glucose dialysate and that impairment of the intercellular junctions of peritoneal mesothelial cells by high glucose dialysate induces peritoneal hyperpermeability and a progressive reduction in dialysis efficacy.


Assuntos
Glucose/farmacologia , Junções Intercelulares/efeitos dos fármacos , Peritônio/efeitos dos fármacos , Anticorpos/farmacologia , Western Blotting , Divisão Celular/efeitos dos fármacos , Células Cultivadas , Colorimetria , Células Epiteliais/efeitos dos fármacos , Humanos , Técnicas Imunológicas , Peritônio/citologia , Proteínas Recombinantes/farmacologia , Coloração e Rotulagem , Fator de Crescimento Transformador beta/biossíntese , Fator de Crescimento Transformador beta/imunologia , Fator de Crescimento Transformador beta/farmacologia , Fator de Crescimento Transformador beta1
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