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1.
Front Hum Neurosci ; 18: 1349186, 2024.
Artigo em Inglês | MEDLINE | ID: mdl-38699563

RESUMO

Background: This study aimed to explore the risk factors and potential causes of unilateral classical or idiopathic trigeminal neuralgia (C-ITN) by comparing patients and healthy controls (HCs) with neurovascular compression (NVC) using machine learning (ML). Methods: A total of 84 C-ITN patients and 78 age- and sex-matched HCs were enrolled. We assessed the trigeminal pons angle and identified the compressing vessels and their location and severity. Machine learning was employed to analyze the cisternal segment of the trigeminal nerve (CN V). Results: Among the C-ITN patients, 53 had NVC on the unaffected side, while 25 HCs exhibited bilateral NVC, and 24 HCs showed unilateral NVC. By comparing the cisternal segment of CN V between C-ITN patients on the affected side and HCs with NVC, we identified the side of NVC, the compressing vessel, and certain texture features as risk factors for C-ITN. Additionally, four texture features differed in the structure of the cisternal segment of CN V between C-ITN patients on the unaffected side and HCs with NVC. Conclusion: Our findings suggest that the side of NVC, the compressing vessel, and the microstructure of the cisternal segment of CN V are associated with the risk of C-ITN. Furthermore, microstructural changes observed in the cisternal segment of CN V on the unaffected side of C-ITN patients with NVC indicate possible indirect effects on the CN V to some extent.

2.
BMC Med Imaging ; 24(1): 66, 2024 Mar 18.
Artigo em Inglês | MEDLINE | ID: mdl-38500069

RESUMO

OBJECTIVE: To investigate the altered trends of regional homogeneity (ReHo) based on time and frequency, and clarify the time-frequency characteristics of ReHo in 48 classical trigeminal neuralgia (CTN) patients after a single pain stimulate. METHODS: All patients underwent three times resting-state functional MRI (before stimulation (baseline), after stimulation within 5 s (triggering-5 s), and in the 30th min of stimulation (triggering-30 min)). The spontaneous brain activity was investigated by static ReHo (sReHo) in five different frequency bands and dynamic ReHo (dReHo) methods. RESULTS: In the five frequency bands, the number of brain regions which the sReHo value changed in classical frequency band were most, followed by slow 4 frequency band. The left superior occipital gyrus was only found in slow 2 frequency band and the left superior parietal gyrus was only found in slow 3 frequency band. The dReHo values were changed in midbrain, left thalamus, right putamen, and anterior cingulate cortex, which were all different from the brain regions that the sReHo value altered. There were four altered trends of the sReHo and dReHo, which dominated by decreased at triggering-5 s and increased at triggering-30 min. CONCLUSIONS: The duration of brain function changed was more than 30 min after a single pain stimulate, although the pain of CTN was transient. The localized functional homogeneity has time-frequency characteristic in CTN patients after a single pain stimulate, and the changed brain regions of the sReHo in five frequency bands and dReHo complemented to each other. Which provided a certain theoretical basis for exploring the pathophysiology of CTN.


Assuntos
Mapeamento Encefálico , Neuralgia do Trigêmeo , Humanos , Neuralgia do Trigêmeo/diagnóstico por imagem , Imageamento por Ressonância Magnética , Encéfalo/diagnóstico por imagem , Dor
3.
Cereb Cortex ; 34(1)2024 01 14.
Artigo em Inglês | MEDLINE | ID: mdl-38012118

RESUMO

The present study aimed to clarify the brain function of classical trigeminal neuralgia (CTN) by analyzing 77 CTN patients and age- and gender-matched 73 healthy controls (HCs) based on three frequency bands of the static and dynamic amplitude of low-frequency fluctuation, regional homogeneity, and degree centrality (sALFF, sReHo, sDC, dALFF, dReHo, and dDC). Compared to HCs, the number of altered brain regions was different in three frequency bands, and the classical frequency band was most followed by slow-4 in CTN patients. Cerrelellum_8_L (sReHo), Cerrelellum_8_R (sDC), Calcarine_R (sDC), and Caudate_R (sDC) were found only in classical frequency band, while Precuneus_L (sALFF) and Frontal_Inf_Tri_L (sReHo) were found only in slow-4 frequency band. Except for the above six brain regions, the others overlapped in the classical and slow-4 frequency bands. CTN seriously affects the mental health of patients, and some different brain regions are correlated with clinical parameters. The static and dynamic indicators of brain function were complementary in CTN patients, and the changing brain regions showed frequency specificity. Compared to slow-5 frequency band, slow-4 is more consistent with the classical frequency band, which could be valuable in exploring the pathophysiology of CTN.


Assuntos
Fenômenos Fisiológicos do Sistema Nervoso , Neuralgia do Trigêmeo , Humanos , Lobo Parietal , Encéfalo/diagnóstico por imagem , Imageamento por Ressonância Magnética
4.
IEEE Trans Med Imaging ; 43(5): 1715-1726, 2024 May.
Artigo em Inglês | MEDLINE | ID: mdl-38153819

RESUMO

Massive high-quality annotated data is required by fully-supervised learning, which is difficult to obtain for image segmentation since the pixel-level annotation is expensive, especially for medical image segmentation tasks that need domain knowledge. As an alternative solution, semi-supervised learning (SSL) can effectively alleviate the dependence on the annotated samples by leveraging abundant unlabeled samples. Among the SSL methods, mean-teacher (MT) is the most popular one. However, in MT, teacher model's weights are completely determined by student model's weights, which will lead to the training bottleneck at the late training stages. Besides, only pixel-wise consistency is applied for unlabeled data, which ignores the category information and is susceptible to noise. In this paper, we propose a bilateral supervision network with bilateral exponential moving average (bilateral-EMA), named BSNet to overcome these issues. On the one hand, both the student and teacher models are trained on labeled data, and then their weights are updated with the bilateral-EMA, and thus the two models can learn from each other. On the other hand, pseudo labels are used to perform bilateral supervision for unlabeled data. Moreover, for enhancing the supervision, we adopt adversarial learning to enforce the network generate more reliable pseudo labels for unlabeled data. We conduct extensive experiments on three datasets to evaluate the proposed BSNet, and results show that BSNet can improve the semi-supervised segmentation performance by a large margin and surpass other state-of-the-art SSL methods.


Assuntos
Algoritmos , Processamento de Imagem Assistida por Computador , Aprendizado de Máquina Supervisionado , Humanos , Processamento de Imagem Assistida por Computador/métodos , Redes Neurais de Computação , Imageamento por Ressonância Magnética/métodos
5.
Medicine (Baltimore) ; 96(51): e9355, 2017 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-29390521

RESUMO

RATIONALE: Solitary fibrous tumors (SFTs) are rare spindle cell tumors that are most commonly found in the mediastinal pleura. Although there are increasingly more reports of extra-pleural SFTs, reports of SFTs in bone are very rare. To our knowledge, a SFT of the ilium has not yet been reported. With low specificity on computer tomograpy and magnetic resonance imaging, SFTs are easily misdiagnosed. PATIENT CONCERNS: A 33-year-old man visited our hospital due to repeated right ilium pain for 3 months. The pain was dull and bearable, with no hip joint dyskinesia. The relevant physical examinations are negative. The patient was healthy before and had a negative family history. Radiologically, a large mass with inhomogeneous attenuation and intensity and obvious heterogeneous enhancement was misdiagnosed as a giant cell tumor of ilium. DIAGNOSES: The man was diagnosed as the solitary fibrous tumor of right ilium. INTERVENTIONS: The patient was performed an "incision biopsy of the right ilium" and "extended resection of tumor". OUTCOMES: The pathology and immunohistochemistry was confirmed as the solitary fibrous tumors. The patient was followed-up by computed tomography of pelvis in local hospital every 6 mouths, and there is no recurrence and any symptoms. LESSONS: We learned that the solitary fibrous tumor could locate in the ilium, and when we see imaging manifestations like this case, we should think it may be SFT.


Assuntos
Neoplasias Ósseas/diagnóstico por imagem , Neoplasias Ósseas/cirurgia , Ílio/patologia , Tumores Fibrosos Solitários/diagnóstico por imagem , Tumores Fibrosos Solitários/cirurgia , Dor Abdominal/diagnóstico , Dor Abdominal/etiologia , Adulto , Biópsia por Agulha , Neoplasias Ósseas/patologia , Seguimentos , Humanos , Imuno-Histoquímica , Imageamento por Ressonância Magnética/métodos , Masculino , Doenças Raras , Medição de Risco , Tumores Fibrosos Solitários/patologia , Tomografia Computadorizada por Raios X/métodos , Resultado do Tratamento
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