Pd(II)-catalyzed synthesis of benzisoxazolones from benzohydroxamic acids via C-H activation.

A Pd-catalyzed method for the synthesis of benzisoxazolones from benzohydroxamic acids using Oxone as an oxidant in a one-pot procedure has been developed. In this process, the reaction appears to be suitable for construction of various benzisoxazolones.

Palladium-catalyzed divergent reactions of 1,6-enyne carbonates: synthesis of vinylidenepyridines and vinylidenepyrrolidines.

A method for preparing five- or six-membered heterocyclic compounds from enyne carbonates via palladium catalysis was developed. Enyne carbonates were transformed into 3-vinylidene-1-tosylpyridines 2 in the presence of PdI(2) as the catalyst. Using Pd(dba)(2) as the catalyst, 3-vinylidene-1-tosylpyrrolidines 3 were obtained. Further functionalizations of compounds 3 were carried out in a one-pot manner.

Bi(III)-catalyzed intermolecular reactions of (Z)-pent-2-en-4-yl acetates with ethynylarenes for the construction of multisubstituted fluorene skeletons through a cascade electrophilic addition/cycloisomerization sequence.

A Bi(III)-catalyzed method for the synthesis of highly conjugated aromatic multisubstituted fluorene with (Z)-pent-2-en-4-yl acetates and ethynylarenes via domino reaction is described. In this process, the reaction appears to be very general and suitable for a variety of multisubstituted fluorene.

Cu(I)-catalyzed synthesis of imidazo[1,2-a]pyridines from aminopyridines and nitroolefins using air as the oxidant.

A copper-catalyzed method for the synthesis of imidazo[1,2-a]pyridines with aminopyridines and nitroolefins using air as oxidation agent in a one-pot procedure has been developed. In this process, the reaction appears to be very general and suitable for construction of a variety of imidazo[1,2-a]pyridines.

Cu (I)-catalyzed synthesis of polysubstituted pyrroles from dialkyl ethylenedicarboxylates and beta-enamino ketones or esters in the presence of O2.

A straightforward method for the synthesis of polysubstituted pyrroles was achieved easily from oxidative cyclization of beta-enamino ketones or esters and alkynoates catalyzed by CuI in the presence of O(2).