RESUMO
Cefotiam (CTM) was administered to 52 patients with infectious disease associated with respiratory system, hematological malignancy, urinary system and other system. Good clinical responses were obtained in 38 out of 52 cases (73.1%). Neither objective and subjective side effects nor extreme abnormalities of laboratory tests were observed in these patients. It can be, therefore, concluded that CTM is 1 of the most useful drugs for infectious diseases in respiratory system, hematological malignancy, urinary system and other system.
Assuntos
Cefotaxima/análogos & derivados , Infecções Respiratórias/tratamento farmacológico , Adolescente , Adulto , Idoso , Infecções Bacterianas/tratamento farmacológico , Cefotaxima/efeitos adversos , Cefotaxima/uso terapêutico , Cefotiam , Avaliação de Medicamentos , Feminino , Doenças Hematológicas/complicações , Humanos , Masculino , Pessoa de Meia-Idade , Sepse/tratamento farmacológico , Infecções Urinárias/tratamento farmacológicoAssuntos
Metabolismo dos Carboidratos , Dissacarídeos , Hidrogênio/análise , Absorção Intestinal , Lactose , Lactulose , Adulto , Fatores Etários , Idoso , Testes Respiratórios , Feminino , Humanos , Masculino , Fatores SexuaisRESUMO
1. The incidence of milk intolerance is approximately 19% in Japanese adults when 200 ml of milk is given. However, a much greater incidence was assumed when considered under the criteria of Western standard. 2. The lactase activity was significantly greater in milk drinkers than non-drinkers. And, internationally, the active is higher in those nationalities whose milk consumption is greater. 3. Lactase is an adaptive enzyme and rather easily induced by lactose load feeding in animals. From the data of our own and of the literature, it was further confirmed that environmental factors play a more important role than genetic factors in the etio-pathogenesis of milk intolerance.
Assuntos
Povo Asiático , Intolerância à Lactose/etiologia , Adolescente , Adulto , Animais , Criança , Dissacaridases/metabolismo , Humanos , Mucosa Intestinal/enzimologia , Japão , Jejuno/enzimologia , Teste de Tolerância a Lactose , RatosRESUMO
Ultramicrostructural changes of the mucosa of the small intestine were studied in relation to the alterations of the lactase activity, measuring the height of microvilli by electron microscopy and the enzyme activity by the method of Dahlqvist. Studies with clinical cases revealed that the height of microvilli correlated with the lactase activity significantly (p less than 0.01), and that patients with relatively higher microvilli had a correspondingly higher activity of lactase. In animal experiments an increase of lactase activity by lactose load feeding and low calorie feeding resulted in a raise in the height of microvilli. It was concluded that lactase deficiency in adults and in various gastrointestinal diseases, where no histological abnormality was observed by light microscopy is perhaps due to shortening of the microvilli of the mucosa. It was speculated that the microvillous change and the sequential hypolactasia may be the initial ultramicrostructural and enzymatic alteration in the diffuse disease of the small intestine.
