RESUMO
A new anthraquinone derivative, lupinacidin C (1), was isolated from the endophytic actinomycete Micromonospora lupini. The structure was elucidated on the basis of spectroscopic analyses, and the absolute configuration was determined by total synthesis. Lupinacidin C (1) exhibited the most potent inhibitory effects among the congeners on the invasion of murine colon carcinoma cells into the reconstituted basement membrane.
Assuntos
Antraquinonas/isolamento & purificação , Antraquinonas/farmacologia , Antineoplásicos/isolamento & purificação , Antineoplásicos/farmacologia , Micromonospora/química , Animais , Antraquinonas/química , Antineoplásicos/química , Membrana Basal/efeitos dos fármacos , Neoplasias do Colo , Ensaios de Seleção de Medicamentos Antitumorais , Lupinus/microbiologia , Camundongos , Estrutura Molecular , Ressonância Magnética Nuclear Biomolecular , Nódulos Radiculares de Plantas/microbiologia , Espanha , EstereoisomerismoRESUMO
Brartemicin (1), a new trehalose-derived metabolite, was isolated from the culture broth of the actinomycete of the genus Nonomuraea. Its structure and absolute configuration were determined by spectroscopic analyses. The new compound inhibited the invasion of murine colon carcinoma 26-L5 cells with an IC(50) value of 0.39 microM in a concentration-dependent manner without showing cytotoxic effects.
Assuntos
Actinobacteria/química , Antineoplásicos/isolamento & purificação , Antineoplásicos/farmacologia , Trealose/análogos & derivados , Trealose/farmacologia , Animais , Antineoplásicos/química , Artemisia/microbiologia , Neoplasias do Colo , Relação Dose-Resposta a Droga , Ensaios de Seleção de Medicamentos Antitumorais , Concentração Inibidora 50 , Camundongos , Estrutura Molecular , Ressonância Magnética Nuclear Biomolecular , Trealose/químicaRESUMO
Two novel anthraquinones, lupinacidins A (1) and B (2), have been isolated from the culture broth of a new endophytic actinomycete belonging to the genus Micromonospora. Lupinacidins were found to show significant inhibitory effects on the invasion of murine colon 26-L5 carcinoma cells without inhibiting cell growth.
