RESUMO
Objective The purpose of this study was to investigate the efficacy and safety of bortezomib +doxorubicin + dexamethasone (PAD) regimen in the treatment of patients with multiple myeloma (MM) . Methods Thirty-eight patients with MM in our hospital were selected and randomly divided into observation group and control group with 19 cases in each. The observation group was treated with PAD regimen and the control group was treated with VAD regimen (vincristine+doxorubicin+dexamethasone) . Clinical efficacy and adverse reaction were compared between the two groups. Results The effective rate and total effective rate of the observation group were 52.63%and 78.95%respectively, which were significantly higher than those of the control group ( 0.05) . Conclusion PAD regimen could improve the clinical effect of treating patients with MM, and the adverse reactions can be tolerated. It is safe and worthy of clinical application.
RESUMO
This paper investigates the sandy desertification change between 1986 and 2000 in the western Jilin province, North China. Land use and land cover data were obtained from Landsat TM data by using a supervised classification approach. We summarized the total area of desertified land by each county, as well as the area for each of the four categories of desertified land. The changes of different types of land use and land cover between 1986 and 2000 were calculated and analyzed. Taking Tongyu and Qianan as examples, both human and natural driving forces of the sandy desertification were analyzed. Our analyses indicate that the material sources and windy, warm and dry climate are the immanent causes of potential land desertification, while the irrational human activities, such as deforestation, reclaiming and grazing in the grassland, are the external causes of potential land desertification. However, rational human activities, such as planting trees and restoring grassland can reverse the land desertification process. Furthermore, the countermeasures and suggestions for the sustainable development in ecotone between agriculture and animal husbandry in North China are put forward.
