1.
Org Lett
; 23(5): 1616-1620, 2021 Mar 05.
Artigo
em Inglês
| MEDLINE
| ID: mdl-33570959
RESUMO
A ruthenium-catalyzed asymmetric hydrogenation method for the synthesis of functionalized ß-aryl cyclohexanols is described. With chiral spiro ruthenium catalyst (Ra,S,S)-5c, a series of racemic α-aryl cyclohexanones bearing a ß-monoethylene ketal group were hydrogenated to the corresponding functionalized ß-aryl cyclohexanols in high yields with enantioselectivity of up to 99% ee via a dynamic kinetic resolution. This protocol can be conducted on a decagram scale and provide potential approaches for the synthesis of optically active and densely functionalized aryl cyclohexanols.