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1.
Pediatr Neonatol ; 51(4): 238-241, 2010 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-20713289

RESUMO

Hypocalcemia most frequently occurs in premature neonates. It is usually treated by intravenous (iv) calcium supplementation. However, complications caused by extravasation of iv calcium gluconate include localized soft tissue calcification, necrosis, cellulitis, osteomyelitis, and even compartment syndrome. We present a rare case of iatrogenic calcinosis cutis complicated by compartment syndrome secondary to extravasation of iv calcium gluconate in a neonate. Emergent fasciotomy was performed twice for decompression of compartment syndrome. Histologic findings revealed necrosis and calcification. Appropriate antibiotics were administered to control secondary infection. To the best of our knowledge, there were no previous case reports of calcinosis cutis with compartment syndrome in infants. Although iatrogenic calcinosis cutis is generally a benign entity, the early recognition of the presentation of extravasation of calcium gluconate is important to avoid severe complications and possible medical malpractice disputes. This report aims to raise doctors' awareness of the presentation, course, and management of this relatively rare iatrogenic complication.


Assuntos
Calcinose/induzido quimicamente , Gluconato de Cálcio/efeitos adversos , Síndromes Compartimentais/etiologia , Extravasamento de Materiais Terapêuticos e Diagnósticos/complicações , Hipocalcemia/tratamento farmacológico , Dermatopatias/induzido quimicamente , Calcinose/diagnóstico , Calcinose/terapia , Síndromes Compartimentais/diagnóstico , Síndromes Compartimentais/terapia , Humanos , Hipocalcemia/complicações , Hipocalcemia/patologia , Recém-Nascido , Recém-Nascido Prematuro , Doenças do Prematuro , Masculino , Dermatopatias/diagnóstico , Dermatopatias/terapia
2.
Asian Pac J Allergy Immunol ; 27(4): 173-80, 2009 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-20232571

RESUMO

The cysteinyl leukotrienes cause bronchoconstriction, increased mucus production and airway inflammation, three major features of asthma. Several randomized controlled trials have shown the efficacy of leukotriene receptor antagonists for improving asthma outcomes. The drug is favored for treating childhood asthma, where poor compliance with inhalation therapy is a therapeutic challenge. To assess the effectiveness of Montelukast in asthmatic children under real-life conditions, a prospective, single-arm, multicenter, open-label observational study was performed on asthmatic children 2- to 14-years-old with a history of physician-diagnosed mild persistent asthma. Montelukast was given once daily for 12 consecutive weeks. By the end a significant improvement of the daytime asthma symptom score, nighttime asthma score, peak expiratory flow rate (PEFR) and mean score of the investigators' global evaluation was noted (p < 0.05). These results suggest that montelukast is an effective monotherapy controller in children with mild persistent asthma.


Assuntos
Acetatos/administração & dosagem , Asma/tratamento farmacológico , Antagonistas de Leucotrienos/administração & dosagem , Quinolinas/administração & dosagem , Acetatos/efeitos adversos , Adolescente , Asma/fisiopatologia , Criança , Pré-Escolar , Ciclopropanos , Progressão da Doença , Feminino , Humanos , Antagonistas de Leucotrienos/efeitos adversos , Masculino , Pico do Fluxo Expiratório , Estudos Prospectivos , Quinolinas/efeitos adversos , Índice de Gravidade de Doença , Sulfetos , Resultado do Tratamento
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