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1.
Sci Rep ; 11(1): 20490, 2021 10 14.
Artigo em Inglês | MEDLINE | ID: mdl-34650180

RESUMO

This study aimed to retrospectively analyse the effect of the baseline luteinising hormone/follicle-stimulating hormone ratio (bLH/FSH) on the live-birth rate per fresh-embryo transfer cycle (LBR/ET) in infertile women with polycystic ovary syndrome (PCOS) who received a fresh-embryo transfer. A total of 424 patients with PCOS who underwent the first cycle of in vitro fertilisation (IVF)/intracytoplasmic sperm injection (ICSI) fresh-embryo transfer at our hospital was enrolled. Univariate and multivariate logistic regression analyses, along with curve fitting and a threshold effect analysis, were performed. Baseline LH/FSH levels were a significant (P < 0.05) independent risk factor affecting live birth. In the first IVF/ICSI antagonist treatment cycles, LBR/ET after fresh-embryo transfer was relatively flat, until bLH/FSH was 1.0; thereafter, it started to decrease by 17% for every 0.1-unit bLH/FSH increase. Considering the decline in LBR/ET, it is recommended that PCOS women with bLH/FSH > 1.0 carefully consider fresh-embryo transfer during their first IVF/ICSI.


Assuntos
Coeficiente de Natalidade , Transferência Embrionária/métodos , Hormônio Foliculoestimulante/sangue , Hormônio Luteinizante/sangue , Adulto , China , Estudos de Coortes , Feminino , Fertilização in vitro , Humanos , Infertilidade Feminina/terapia , Síndrome do Ovário Policístico , Gravidez , Estudos Retrospectivos , Injeções de Esperma Intracitoplásmicas
2.
Nan Fang Yi Ke Da Xue Xue Bao ; 36(3): 351-5, 2016 Mar.
Artigo em Chinês | MEDLINE | ID: mdl-27063161

RESUMO

OBJECTIVE: To explore the role of F10 gene in regulating cell cycles of choriocarcinoma cells and the underlying mechanisms. METHODS: Using untreated cells as the control, JAR cells with F10 gene silencing or stable F10 over-expression were examined for cell cycle changes by flow cytometry (FCM) and for expressions of cyclin and cyclin-dependent kinase (CDKs) with Western blotting and immunofluorescence technique. RESULTS: JAR cells over-expressing F10 gene showed reduced duration of cell cycle compared with untreated and with cells after F10 gene silencing. In F10-over-expressing cells, Western blotting revealed significantly up-regulated expressions of cyclin A2, B1, D1, E and CDK2, 6, and 7, but not CDK4, as compared with the control cells and cells with F10 gene silencing (P<0.05), and these results were consistent with those by immunofluorescence assay. CONCLUSION: F10 gene may accelerate cell cycle progression and promote cell proliferation by up-regulating the expressions of cyclin A2, B1, D1, E and CDK 2, 4, 6, 7 in choriocarcinoma cells.


Assuntos
Ciclo Celular , Coriocarcinoma/metabolismo , Fator X/genética , Inativação Gênica , Divisão Celular , Linhagem Celular Tumoral , Proliferação de Células , Quinases Ciclina-Dependentes/metabolismo , Ciclinas/metabolismo , Feminino , Humanos , Gravidez
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