Facile synthesis of 1-thio-beta-lactoside clusters scaffolded onto p-methoxyphenyl, beta-D-galactopyranoside, beta-D-glucopyranoside, and lactoside.

The free-radical addition of 2,3,4,6-tetra-O-acetyl-beta-D-galactopyranosyl-(1-->4)-2,3,6-tri-O-acetyl-1-thio-beta-D-glucopyranose to the allyl ether functions of p-methoxyphenyl per-O-allyl-D-galactopyranoside, D-glucopyranoside, and lactoside provides a concise and effective route for synthesis of glycoside clusters, of use for exploring anti-metastatic activity.