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2.
BMC Urol ; 20(1): 188, 2020 Nov 26.
Artigo em Inglês | MEDLINE | ID: mdl-33243200

RESUMO

BACKGROUND AND AIMS: It has been reported that Helicobacter pylori (HP) infection was more prevalent in infertile populations. HP infection could lead to decreased sperm parameters, and treating the HP infection could improve the quality of sperm. However, studies investigating the relationship between infertility and HP infection are still limited, and more evidence is required. Therefore, we performed the present study to investigate the impact of HP infection on sperm quality in males and on ovarian reserve in females. METHODS: A total of 16,522 patients who visited the Second Hospital of Zhejiang University from January 2016 to June 2019 due to abdominal discomfort and underwent a 13/14C-urea breath HP test were included in this retrospective cross-sectional study. Among them, 565 had performed sperm analysis or ovarian reserve tests in the past three months and were involved for further analyses. Sperm parameters were examined with a computer-assisted sperm analysis system, and serum anti-Müllerian hormone (AMH) and sex hormones were tested with an electrochemiluminescence method. RESULTS: Among 363 patients who underwent the sperm test, 136 (37.47%) had HP infection. Among 202 patients who underwent the AMH test, 55 (27.23%) had HP infection. There was no difference in sperm concentration and motility between the HP+ and HP- groups (P > 0.05). Further subgroup analyses stratified into 5-year age groups confirmed that there was no significant difference in sperm parameters (P > 0.05). When pooled with previously published data, no significant difference in sperm concentration or motility was found (P > 0.05). Meanwhile, this study found that the serum AMH level was similar between the HP+ and HP- groups (P > 0.05). Further subgroup analyses confirmed that there was no significant difference in serum AMH level (P > 0.05). CONCLUSIONS: There were no differences in sperm parameters and AMH levels based on history of HP infection among Chinese patients.


Assuntos
Hormônio Antimülleriano/sangue , Infecções por Helicobacter/sangue , Infecções por Helicobacter/fisiopatologia , Helicobacter pylori , Reserva Ovariana , Análise do Sêmen , Adulto , Estudos Transversais , Feminino , Humanos , Masculino , Estudos Retrospectivos
3.
BMC Endocr Disord ; 20(1): 101, 2020 Jul 08.
Artigo em Inglês | MEDLINE | ID: mdl-32641160

RESUMO

BACKGROUND: Anti-Müllerian hormone (AMH) is now considered the best serum biomarker of ovarian reserve, while basal sex hormones are classic markers used for assessing ovarian reserve. The interaction between AMH and sex hormones are complicated and not sufficiently addressed. In this study, we took diminished ovarian reserve (DOR) and polycystic ovarian syndrome (PCOS) as two extremes of ovarian reserve (deficient and excessive respectively) to investigate the role of AMH and sex hormones in follicular growth. METHODS: A retrospective cross-sectional survey was performed. The patients assessed AMH and basal sex hormones in the Second Hospital of Zhejiang University from April 2016 to March 2019 were involved in this study. Serum AMH and sex hormone concentrations were tested with electrochemiluminescence method. Stepwise linear regression and binary logistic regression was used to determine the predictors of AMH level and to explore the involved factors determining DOR and PCOS. RESULTS: In the present study, we found that age and follicle-stimulating hormone (FSH) were main negative correlation factors, and luteinizing hormone (LH) and testosterone (T) were main positive factors of AMH. In DOR group, age, FSH and estradiol (E2) increased and T decreased, while in PCOS group, LH and T increased. Binary logistic regression found that age, weight, FSH, E2, and T were the significant factors which independently predicted the likelihood of DOR, and that age, body mass index (BMI), AMH, LH, and T predicted the likelihood of PCOS. CONCLUSIONS: Our study demonstrated that age, FSH, and T were factors that most closely correlated with AMH level, and T was involved in both DOR and PCOS. Since DOR and PCOS are manifested with insufficient AMH and excessive AMH respectively, it is suggested that total testosterone correlated with AMH closely and plays an important role in follicular growth. More attention should be given to testosterone level during controlled ovarian hyperstimulation (COH) process.


Assuntos
Hormônio Antimülleriano/sangue , Folículo Ovariano/citologia , Reserva Ovariana , Síndrome do Ovário Policístico/patologia , Testosterona/sangue , Adulto , China/epidemiologia , Estudos Transversais , Feminino , Humanos , Folículo Ovariano/metabolismo , Síndrome do Ovário Policístico/sangue , Síndrome do Ovário Policístico/epidemiologia , Estudos Retrospectivos
4.
Sleep Breath ; 16(3): 717-22, 2012 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-21928076

RESUMO

OBJECTIVE: This study aims to examine the impact of chronic intermittent hypoxia on hearts in patients with obstructive sleep apnea (OSA). METHODS: Two hundred twenty patients were divided into groups based on (1) severity of the disease, (2) years of disease history, and (3) with or without secondary hypertension. All subjects underwent blood pressure measurements, polysomnogram monitoring, and cardiac Doppler ultrasound examinations. RESULTS: The left ventricular ejection fraction (LVEF), fractional shortening (FS), and the ratio of early to late diastolic filling (E/A) in patients with severe OSA were lower than in those with moderate OSA and in healthy controls. The inner diameters of the main pulmonary artery (inD of MPA), the inner diameters of the right cardiac ventricle (inD of RV), and the thickness of anterior wall of the right ventricle (TAW of RV) were increased in patients with severe OSA compared to those with moderate disease and worsened as a function of time with disease. The tissue Doppler imaging-derived Tei index and pulmonary artery systolic pressure were also increased along with the severity of OSA. LVEF and FS in patients who had suffered from OSA for >10 years were decreased compared with those suffering from OSA for a shorter time. LVEF and FS in patients with secondary hypertension were decreased significantly relative to non-hypertensive OSA patients and healthy controls. E/A was decreased in OSA patients whether they had secondary hypertension or not. CONCLUSION: OSA affected the left ventricular diastolic function in the early stage of the disease. Extended exposure to OSA resulted in left ventricular dysfunction with increased hypertension. Right ventricle dysfunction and abnormalities became more severe as the disease progressed.


Assuntos
Hemodinâmica/fisiologia , Hipóxia/fisiopatologia , Apneia Obstrutiva do Sono/complicações , Apneia Obstrutiva do Sono/fisiopatologia , Disfunção Ventricular Esquerda/fisiopatologia , Disfunção Ventricular Direita/fisiopatologia , Adulto , Idoso , Idoso de 80 Anos ou mais , Consumo de Bebidas Alcoólicas/efeitos adversos , Consumo de Bebidas Alcoólicas/fisiopatologia , Índice de Massa Corporal , Progressão da Doença , Ecocardiografia , Técnicas de Imagem por Elasticidade , Feminino , Humanos , Hipertensão/diagnóstico , Hipertensão/fisiopatologia , Hipóxia/diagnóstico , Masculino , Pessoa de Meia-Idade , Oxigênio/sangue , Polissonografia , Valores de Referência , Apneia Obstrutiva do Sono/diagnóstico , Fumar/efeitos adversos , Fumar/fisiopatologia , Volume Sistólico/fisiologia , Disfunção Ventricular Esquerda/diagnóstico , Disfunção Ventricular Direita/diagnóstico
5.
Zhonghua Jie He He Hu Xi Za Zhi ; 33(5): 336-40, 2010 May.
Artigo em Chinês | MEDLINE | ID: mdl-20646610

RESUMO

OBJECTIVE: To investigate the influence of left heart function in obstructive sleep apnea by CIH, and explore left heart function and blood pressures before or after CPAP. METHODS: 75 OSA were divided into two groups: 40 patients blood pressures were coincident with diagnostic standard of hypertension recording; 35 patients blood pressures were non-hypertension recording. The control group included 30. healthy adults. The blood pressures before and also after sleep, left ventricular ejection fraction (LVEF), shortening fraction (FS), E, A and E/A were compared with those of normal control subjects. Analyzed BP, LVEF and E/A after CPAP. RESULTS: (1) The blood pressure soon after getting up in the morning (150.80+/-20.73/108.0+/-15.34) mm Hg (1 mm Hg=0.133 kPa) was significantly higher than that before sleep (134.16+/-18.33/90.09+/-11.24) mm Hg (P<0.001). (2) Multiple parameters including LVEF, FS and E/A, were impaired in OSA patients relative to the control subjects (P<0.05 or P<0.01), OSA affected cardiovascular function directly; E/A was significantly decreased in obstructive sleep apnea unallied hypertension than that in normal control subjects; E/A was conspicuously decreased in obstructive sleep apnea associated hypertension comparing with that in obstructive sleep apnea unallied hypertension. These showed OSA affected cardiovascular function directly, hypertension aggravated the drop in cardiovascular function. 3. After CPAP in 6 months, it (142.59+/-15.34/96.52+/-9.81) mm Hg was significantly decreased than that before treatment (150.80+/-20.73/108.0+/-15.34) (P<0.001); LVEF (59.70+/-11.1)% was increased than that before treatment (56.40+/-9.74)% (P<0.05) and E/A 1.16+/-0.25 was increased. Than that before treatment 0.87+/-0.17 (P<0.01). CONCLUSION: (1) CIH may affect left heart structure and function; these changes were aggravated with hypertension. (2) CPAP treatment had important sense in the treatment of hypertension and cardiovascular function, and improved the life quality.


Assuntos
Pressão Sanguínea , Hipertensão/fisiopatologia , Hipóxia/diagnóstico por imagem , Hipóxia/fisiopatologia , Apneia Obstrutiva do Sono/fisiopatologia , Adulto , Idoso , Estudos de Casos e Controles , Pressão Positiva Contínua nas Vias Aéreas , Ecocardiografia Doppler em Cores , Feminino , Frequência Cardíaca , Humanos , Masculino , Pessoa de Meia-Idade , Apneia Obstrutiva do Sono/diagnóstico por imagem , Função Ventricular Esquerda
6.
Zhonghua Yi Xue Za Zhi ; 89(42): 2980-2, 2009 Nov 17.
Artigo em Chinês | MEDLINE | ID: mdl-20137708

RESUMO

OBJECTIVE: To investigate the effects of obstructive sleep apnea-hypopnea syndrome (OSAHS) upon cardiac structure and function of patients. METHODS: According to apnea hypopnea index, 75 OSAHS patients were divided into three groups: mild (n = 25), moderate (n = 25) and serious (n = 25); according to the course of disease, < 5 years (n = 22), 5-10 years (n = 26) and > 10 years (n = 27). The control group included 25 healthy adults. All subjects received polysomnogram and echocardiography. The following parameters were recorded: aortic dimension, pulmonary artery inner diameter, chambers heart size, interventricular septal thickness, anterior wall thickness and movement extent of end-diastole right ventricle, left ventricular ejection fraction (LVEF), shortening fraction (FS) and E/A ratio, etc. RESULTS: Pulmonary artery inner diameter of mild, moderate, serious and control groups were (21.4 +/- 2.5), (24.7 +/- 2.0), (26.7 +/- 2.1), (21.2 +/- 2.7) mm, right ventricle internal diameter (19.0 +/- 1.8), (22.0 +/- 2.1), (23.9 +/- 2.1), (18.9 +/- 1.8) mm, and anterior wall thickness of right ventricle (4.7 +/- 1.2), (6.5 +/- 1.3), (7.5 +/- 1.4), (4.1 +/- 1.0) mm. The moderate and serious groups were all higher than control and mild groups obviously (P < 0.01). The serious group was higher than the moderate group (P < 0.01). LVEF of four groups: (63.1 +/- 8.1)%, (60.0 +/- 10.2)%, (54.5 +/- 9.1)%, (63.6 +/- 7.7)%, FS: (38.1 +/- 4.3)%, (37.0 +/- 6.4)%, (33.6 +/- 5.4)%, (39.5 +/- 4.9)%, and E/A: (1.13 +/- 0.13), (0.96 +/- 0.16), (0.85 +/- 0.12), (1.28 +/- 0.15). LVEF and FS of the serious group were lower than those of the control, mild and moderate groups (P < 0.05). E/A ratio of the mild, moderate and serious groups were lower than the control group (P < 0.01). The interclass comparison of mild, moderate and serious groups had significant differences (P < 0.01). Right ventricle internal diameter, pulmonary artery inner diameter, anterior wall thickness of right ventricle of > 10 years group were higher than 5-10 years group obviously (P < 0.05, P < 0.01). The 5-10 years group was higher than the < 5 years and control groups obviously (P < 0.05, P < 0.01). LVEF, FS, and E/A ratio of > 10 years group were lower than 5-10 years, < 5 years and control groups obviously (P < 0.05, P < 0.01). CONCLUSION: OSAHS causes structural and functional cardiac changes worsening with disease aggravation and course extension.


Assuntos
Coração/fisiopatologia , Apneia Obstrutiva do Sono/diagnóstico por imagem , Apneia Obstrutiva do Sono/fisiopatologia , Adulto , Idoso , Estudos de Casos e Controles , Ecocardiografia , Feminino , Humanos , Masculino , Pessoa de Meia-Idade
7.
Hepatobiliary Pancreat Dis Int ; 1(4): 536-8, 2002 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-14607682

RESUMO

OBJECTIVE: To differentiate diffuse liver cancer from portal cirrhosis by using ultrasonography. METHODS: We analyzed the sonographic images of 15 patients with diffuse liver cancer and 30 patients with portal cirrhosis. RESULTS: The patients with diffuse liver cancer showed enlarged liver and obvious echo of nodules. The rate of portal embolism and swelling of lymph nodes around the porta hepatis was high. The patients with portal cirrhosis showed diminished liver and the obvious echo of fiber proliferation. The rates of spleen enlargement and ascites as well as gallbladder edema were high. CONCLUSIONS: To identify sonographic characteristics inside and outside of the liver. It is helpful in differentiating diffuse liver cancer from portal cirrhosis. The sonographic characteristics inside the liver include surface and size, node echo, echo of fibrous tissue hyperplasia. They are difficult to identify when diffuse liver cancer merges with considerable cirrhosis. The acoustic image characteristics of the two diseases overlap. Hence attention should be paid to the size of the liver, proliferation of cells of diffuse liver carcinoma. In sonographic characteristics outside the liver, embolism of the portal vein and swelling of lymph nodes in the porta hepatis are particularly useful to identify diffuse liver cancer or diffuse liver cancer combined with liver cirrhosis in particular.


Assuntos
Cirrose Hepática/diagnóstico por imagem , Neoplasias Hepáticas/diagnóstico por imagem , Diagnóstico Diferencial , Embolia/diagnóstico por imagem , Feminino , Humanos , Fígado/diagnóstico por imagem , Masculino , Pessoa de Meia-Idade , Veia Porta/diagnóstico por imagem , Ultrassonografia
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