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1.
Psychol Health Med ; : 1-7, 2022 Dec 28.
Artigo em Inglês | MEDLINE | ID: mdl-36578132

RESUMO

China has implemented a strict isolation system in hospitals since the COVID-19 pandemic, that adversely affected the psychology of inpatients and their caregivers. Face-to-face, semi-structured interviews with 22 stroke inpatients from two municipal hospitals were conducted to explore the psychological, emotional and related support needs of stroke inpatients and their family caregivers under this environment. Results which showed that external support for stroke inpatients and their family caregivers was insufficient highlight the necessity for developing specific nursing interventions that meet the psychological and emotional needs of inpatients and the caregivers.

2.
Zhongguo Zhong Yao Za Zhi ; 43(19): 3811-3821, 2018 Oct.
Artigo em Chinês | MEDLINE | ID: mdl-30453703

RESUMO

Usnic acid and its derivatives, a group of organic molecules with great importance, are characteristic to lichens, possessing pharmacological activities such as anti-virus, anti-bacteria, anti-humor, anti-inflammatory, analgesic, and anaesthetic effects. Many of them have been widely used as medicine, but also bring side effects such as dermatitis and liver damages. In the past decades, great efforts by isolation, organic synthesis, and structure modification methods were put on discovery of UA derivatives with higher biological activities or less side effects. This paper describes herein the most progress on natural sources, isolation and structure elucidation, structural characteristics, synthesis and modification results, pharmacological activities and toxicities of UA and its derivatives, hopefully to provide valuable reference for further research.


Assuntos
Benzofuranos/química , Benzofuranos/farmacologia , Líquens/química , Produtos Biológicos
3.
J Asian Nat Prod Res ; 20(5): 439-444, 2018 May.
Artigo em Inglês | MEDLINE | ID: mdl-29580098

RESUMO

Three new triterpenoid saponins, namely asprellinoids A-C (1-3), featuring a sulfate substitution in sugar moiety, were isolated from the stems of Ilex asprella (Hook. et Arn.) Champ. ex Benth. Their structures were elucidated by the spectroscopic data analyses including HR-ESI-MS, IR, and NMR spectra, and chemical method.


Assuntos
Ilex/química , Caules de Planta/química , Saponinas/química , Triterpenos/química , Espectroscopia de Ressonância Magnética , Estrutura Molecular
4.
Zhongguo Zhong Yao Za Zhi ; 42(21): 4154-4158, 2017 Nov.
Artigo em Chinês | MEDLINE | ID: mdl-29271154

RESUMO

Phytochemical investigation on the stems of Ilex asprella by using various chromatographic techniques led to the isolation of 13 compounds. By spectroscopic analyses and comparisons the spectral data with those in literatures, these compounds were identified as salicifoneoliganol(1), rel-(7R,8S)-3,3',5-trimethoxy-4',7-epoxy-8,5'-neolignan-4,9,9'-triol 9-ß-D-glucopyranoside(2),(+)-cycloolivil(3),(+)-syringaresinol-4'-O-ß-D-monoglucoside(4), liriodendrin(5), caffeic acid (6), 3,4-dihydroxy-5-methoxybenzaldehyde(7), benzene-1,2,4-triol(8), 3,4,5-trimethoxyphenyl-1-O-ß-D-apiofuranosyl(1″→6')-glucopyranoside(9), aeculetin(10), cryptochlorogenic acid ethyl ester(11), chlorogenic acid ethyl ester(12), and rel-5-(3S,8S-dihydroxy-1R,5S-dimethyl-7-oxa-6-oxobicyclo [3,2,1]oct-8-yl)-3-methyl-2Z,4E-pentadienoic acid(13). Among them, compounds 7, 8, 11, and 13 were isolated from genus Ilex for the first time, and 1-3, 9, 10, and 12 were isolated from this speciesfor the first time. The anti-inflammatory assay results of these compounds showed that compounds 1 and 9 showed moderate inhibitory effect against NO production in RAW 267. 4 cells with IC50 values of 35.7 and 50.6 µmol•L⁻¹, in vitro respectively, whereas compound 10 showed weak inhibition(IC50 value 98.7 µmol•L⁻¹).


Assuntos
Ilex/química , Compostos Fitoquímicos/farmacologia , Caules de Planta/química , Animais , Anti-Inflamatórios/isolamento & purificação , Anti-Inflamatórios/farmacologia , Camundongos , Estrutura Molecular , Óxido Nítrico/metabolismo , Compostos Fitoquímicos/isolamento & purificação , Células RAW 264.7
5.
Zhongguo Zhong Yao Za Zhi ; 42(1): 20-28, 2017 Jan.
Artigo em Chinês | MEDLINE | ID: mdl-28945020

RESUMO

Ilex asprella is one of representative medicinal plants in South of the Five Ridges of China. The roots and rhizomes of I. asprella have the effects of clearing heat and detoxifying, stimulating salvia, and reducing thirst, which has been used to treat wind-heat cold, acute and chronic pharyngitis, and sore throat. Contemporary studies showed that I. asprella contains the major triterpenoids and glycosides, phenolic acids, and minor steroids. The extracts and compounds show activities of anti-inflammatory, antiviral, anti-tumor, and regulating lipid metabolism.The present paper summarizes a phytochemical and pharmacological advance on this species to provide reference for clarification of its pharmacologically active ingredients, quality evaluation, and further explorations.


Assuntos
Ilex/química , Compostos Fitoquímicos/análise , China , Extratos Vegetais/análise , Raízes de Plantas/química , Plantas Medicinais/química
6.
J Asian Nat Prod Res ; 19(4): 416-422, 2017 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-28367639

RESUMO

One new norlignan, noralashinol B (1), and one new natural product, proposed noralashinol C (2), were isolated in a continuous phytochemical investigation on the stem barks of Syringa pinnatifolia. Their structures were elucidated based on the analysis of spectroscopic data, including mass spectrometry and 1D and 2D NMR spectroscopies, and the absolute configuration was determined by experimental and calculated electronic circular dichroism. Compound 1 showed a weak cytotoxicity against HepG2 hepatic cancer cells with its IC50 value of 31.7 µM. Furthermore, 1 induced apoptosis of HepG2 cells in a dose-dependent manner at concentrations of 0-80.0 µM.


Assuntos
Antineoplásicos Fitogênicos/isolamento & purificação , Antineoplásicos Fitogênicos/farmacologia , Lignanas/isolamento & purificação , Lignanas/farmacologia , Syringa/química , Antineoplásicos Fitogênicos/química , Relação Dose-Resposta a Droga , Ensaios de Seleção de Medicamentos Antitumorais , Células Hep G2 , Humanos , Concentração Inibidora 50 , Lignanas/química , Estrutura Molecular , Ressonância Magnética Nuclear Biomolecular , Casca de Planta/química , Caules de Planta/química
7.
Ying Yong Sheng Tai Xue Bao ; 28(6): 2073-2082, 2017 Jun 18.
Artigo em Chinês | MEDLINE | ID: mdl-29745173

RESUMO

Silver nanoparticles (AgNPs) as one of the most widely used metal nanomaterials can enter soil and water environment via various pathways, exert toxicity on water-borne organisms and deteriorate the aquatic eco-environment. With complex composition of natural water, the physicochemical property of AgNPs as nano materials makes their transformation process more complicated in water system. Therefore, understanding of the fate and transport of AgNPs in aqueous environment is extremely important for water quality management and protection of the eco-environment. Deve-lopment of modern science and technology has made it possible to study the process of the dissolution of AgNPs in environment. This paper summarized the source and risk of AgNPs in environment, analyzed impacts of environmental factors such as pH, dissolved oxygen, ionic strength and intrinsic factors of AgNPs such as particle size and coating on the AgNPs transformation in water environment, and summarized the main analytical techniques for the AgNPs size, potential and morphology. Finally, this paper pointed out the major research gaps in the current research and provided prospective for the future research.


Assuntos
Nanopartículas Metálicas , Prata , Tamanho da Partícula , Estudos Prospectivos , Água
8.
Zhongguo Zhong Yao Za Zhi ; 41(10): 1864-1869, 2016 May.
Artigo em Chinês | MEDLINE | ID: mdl-28895334

RESUMO

Sixteen compounds were isolated from lichen Usnea longissima using of various chromatographic techniques including silica gel, Sephadex LH-20, ODS, and semi-preparative HPLC. By spectroscopic data analyses, their structures were identified by as useanol(1), lecanorin(2), 3-hydroxy-5-methylphenyl 2-hydroxy-4-methoxy-6-methylbenzoate(3), lecanorin E(4), 3'-methylevernic acid(5), evernic acid(6), barbatinic acid(7), 3,7-dihydroxy-1,9-dimethyldibenzofuran(8), orcinol(9), O-methylorcinol(10), methyl orsellinate(11), methyl everninate(12), 2,5-dimethyl-1,3-benzenediol(13), 2-hydroxy-4-methoxy-3,6-dimethyl benzoic acid(14), ethyl everninate(15), and ethyl 2,4-dihydroxy-6-methylbenzoate(16). Compound 1 was obtained as a natural product for the first time, and 3,4, 8,10,12, and 13 were isolated from Usneaceae family for the first time. Compound 1, 8, and 13 showed significant anti-inflammatory activity against NO production in RAW 267.4 cells with IC50 values of 6.8, 3.9 and 4.8 µmol•L⁻¹, respectively, compared with the positive controls curcumin(IC50 15.3 µmol•L⁻¹) and indomethacin(IC50 42.9 µmol•L⁻¹).


Assuntos
Fenóis/isolamento & purificação , Usnea/química , Animais , Cromatografia Líquida de Alta Pressão , Camundongos , Células RAW 264.7
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