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Bull Exp Biol Med ; 163(6): 780-784, 2017 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-29063334

RESUMO

Drug penetration into bacterial biomembranes is one of the most important factors determining the efficiency of antibacterial therapy. Multicide, antibacterial drug, is a nanomolecule 1.3-2.0 nm in size, easily penetrating into staphylococcus biomembranes and causing rapid death of bacteria. The drug efficiency depends on its concentration and duration of exposure. Bacteria die as a result of cell wall perforation, which is associated with changes in its morphology and release of DNA from bacterial cell into the environment. Our results indicate the efficiency of primary damage to bacterial wall leading to elimination of biomembranes.


Assuntos
Antibacterianos/farmacologia , Membrana Celular/efeitos dos fármacos , Parede Celular/efeitos dos fármacos , Staphylococcus aureus/efeitos dos fármacos , Membrana Celular/metabolismo , Membrana Celular/ultraestrutura , Parede Celular/metabolismo , Parede Celular/ultraestrutura , Microscopia Eletrônica , Permeabilidade , Staphylococcus aureus/metabolismo , Staphylococcus aureus/ultraestrutura
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