[Prevalence and influencing factors of hyperuricemia among natural gas drilling workers in Northwest Sichuan gas field in 2016].

OBJECTIVE: To investigate the prevalence and influencing factors of hyperuricemia among natural gas drilling workers in Northwest Sichuan gas field. METHODS: A census of 1051 natural gas drilling workers in Northwest Sichuan gas field at an average altitude of 2552 meters was conducted in the survey, the serum uric acid, fasting blood glucose, blood lipid, creatinine and hemoglobin were detected. A staff canteen was randomly selected and the method of weighing and 24-hour dietary review were used for dietary survey. The blood biochemical level and dietary intake of subjects with different blood uric acid levels were compared, and the influencing factors of hyperuricemia were analyzed by Logistic regression model. RESULTS: (1)There were 513 hyperuricemia patients in natural gas drilling workers, with a detection rate of 48. 8%. (2)The levels of fasting blood glucose, total cholesterol, triglyceride, creatinine and hemoglobin in the hyperuricemia group were higher than those in the normouricemia group. The risk of hyperuricemia in patients with diabetes, hypercholesterolemia, hypertriglyceridemia, elevated serum creatinine and hemoglobin were 3. 57(95%CI 2. 45-4. 67), 2. 88(95%CI 1. 99-4. 16), 1. 93(95%CI 1. 30-2. 86), 1. 61(95%CI 1. 01-2. 51)and 2. 54(95%CI 2. 11-3. 36)times of normal fasting blood glucose, blood lipid, serum creatinine and hemoglobin, respectively(P<0. 05). (3)The intakes of meat, oil and salt in the hyperuricemia group were higher than those in the normouricemia group, while the intakes of vegetables, milk products and vitamin B were lower than those in the normouricemia group(P<0. 05). Intake of vegetable is a protective factor for hyperuricemia(0. 82(95%CI 0. 65-0. 93)), and intakes of protein(1. 47(95%CI 1. 16-2. 28))and fat(2. 34(95%CI 2. 01-3. 22)) are the risk factors. CONCLUSION: Drilling workers in Northwest Sichuan gas field have a high prevalence of hyperuricemia and are related to diabetes, hypercholesterolemia, hypertriglyceridemia, elevated creatinine and hemoglobin, and too much protein, fat intake and too little vegetable intake.

Super Hydrophilic Semi-IPN Fluorescent Poly(N-(2-hydroxyethyl)acrylamide) Hydrogel for Ultrafast, Selective, and Long-Term Effective Mercury(II) Detection in a Bacteria-Laden System.

Convenient, low-cost chemosensors for hazardous mercury ion detection have been receiving more and more attention in recent studies. However, most of these practical studies are based on an ideal sterile detecting atmosphere and ignore the role of bacteria in actual Hg(II) analytes. Herein, we demonstrate a new type of hydrophilic semi-IPN fluorescent polyHEAA hydrogel chemosensors fabricated by UV polymerization in situ interpenetrating fluorescent polymer PA-NDBCB with a polyHEAA network. Because of specific intermolecular interaction, i.e., hydrogen bonding between hydrophilic fluorescent polymer and polyHEAA matrix comprising a distinct semi-IPN structure, the mechanical property of bulk fluorescent hydrogels can be greatly improved over that of pure polyHEAA hydrogels. Moreover, the design of the hydrogel chemosensors rely on the highly efficient cyclization reaction between Hg(II) ions and the thiourea moieties that induce a visible "green-to-blue" fluorescence color change. On account of the hydrophilic porous structures, these hydrogel chemosensors achieve ultrafast, sensitive, selective Hg(II) detection (detection limit of 0.067 µM) and enable facile ratiometric actual detection in real-world aqueous system. Notably, they maintain fluorescence emission and detection property even under long-term coculture in a complex E. coli bacteria-laden environment. This novel strategy could inspire future construction of soft interfaces/fluorescent apparatus for hazardous Hg(II) detection in a complex real-world system.