RESUMO
A previously healthy woman developed severe, recurrent mucocutaneous herpes simplex virus (HSV) infection at 21 years of age. Immunologic assessment over the past 2 years has revealed persistent T-cell and natural killer cell dysfunction despite normal numbers of these cells as measured by flow cytometry. We studied the effect of recombinant interleukin 2 (rIL-2) and gamma globulin on the patient's mononuclear cells in 18-hour 51Cr release assays using HSV-infected and uninfected target cells. Both gamma globulin and rIL-2 significantly enhanced target cell lysis of HSV-infected target cells (P less than .001), but did not increase lysis of uninfected target cells. Addition of the patient's serum had no effect on HSV-infected target cell lysis despite a high HSV IgG titer, indicating a possible specific abnormality in production of antibody-dependent cellular cytotoxicity antibody.
Assuntos
Herpes Simples/terapia , Interleucina-2/uso terapêutico , gama-Globulinas/uso terapêutico , Adulto , Citotoxicidade Celular Dependente de Anticorpos , Citotoxicidade Imunológica , Feminino , Herpes Simples/imunologia , Humanos , Imunidade Inata , Imunoterapia , Células Matadoras Naturais/imunologia , Subpopulações de Linfócitos/imunologia , Recidiva , Linfócitos T/imunologiaRESUMO
After preoperative intubation and administration of intravenous cefuroxime, a 48-year-old white female developed anaphylactic shock that was refractory to the usual therapeutic measures but was responsive to treatment with intravenous cimetidine. Beta-lactam sensitivity was subsequently confirmed by skin testing. Cimetidine, which antagonizes arterial H2 receptors, may be useful in the treatment of anaphylaxis refractory to the usual resuscitative measures.
