[The effectiveness of vacuum therapy and meglumine sodium succinate in unformed fistulas of the gastrointestinal tract (clinical observations)]. / Effektivnost' primeneniya vakuum-terapii i meglyumina natriya suktsinata pri nesformirovannykh svishchakh zheludochno-kishechnogo trakta (klinicheskie nablyudeniya).

The incidence of intestinal fistulas after laparotomy for various reasons (peritonitis, acute pancreatitis or trauma) is 1.5%. Fistula formation in patients with chronic gastrointestinal diseases has a rapid onset, severe course, and poor prognosis. Against the background of a long course of the disease and depletion of the body, there is a decrease in the activity of reparative processes, which leads to the manifestation of postoperative complications: the formation of fistulas, insolvency of intestinal anastomoses, peritonitis. Vacuum drainage is a treatment method aimed at eliminating exudate, reducing the area of the wound and its epithelization. The inclusion of a succinate-containing solution in the treatment regimen improves metabolic processes and improves the prognosis of the disease. As an illustration, a description of the clinical observation of patients with similar pathology and different treatment regimens is given.

Increases in the threshold for the development of epileptiform activity in field CA1 of Krushinskii-Molodnika rat hippocampal slices as an adaptive protective mechanism.

Studies were carried out into the chances of developing epileptiform activity in the neuronal network of hippocampal field CA1 in normal (Wistar) rats and in rats genetically predisposed to audiogenic convulsions (Krushinskii-Molodkina rats). The development of epileptiform activity was assessed in terms of the reduction in the threshold for development trains of epileptiform discharges in field CA1 of hippocampal slices, which were induced using episodic increases in the extracellular K+ concentration ([K+]0) or decreases in the extracellular Mg2+ concentration ([Mg2+]0). These experiments showed that the threshold for the development of trains of epileptiform discharges increased in field CA1 of hippocampal slices of Krushinskii-Molodkina rats, while the excitability of glutamatergic Schaffer collaterals/commissural fibers was decreased. In addition, Krushinskii-Molodkina rats showed no long-term potentiation of glutamatergic synaptic transmission or potentiation of the EPSP-spike system in pyramidal neurons, induced in field CA1 of hippocampal slices in Wistar rats by reductions in [Mg2+]0 and increases in [K+]0 respectively. It is suggested that this underlies the operation of an adaptive protective mechanism preventing the propagation of convulsive activity in the Krushinskii-Molodkina rat brain.